• Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor–Toll-like Receptor 4–Proinflammatory Cytokine Signaling

    Schematic illustration of mechanisms of metabolic syndrome with special reference to Toll-like receptor 4 (TLR4) and proinflammatory cytokine signaling. High-fat diet impairs gut barrier to induce bacterial translocation resulting in dysbiosis. At the same time, dysbiosis reduces gut barrier integrity via the metabolites produced by gut bacteria. Additionally, this change activates the immune system to induce lipopolysaccharide (LPS). LPS activates systemic TLR4 to produce proinflammatory cytokines, resulting in low-grade inflammation, which causes insulin resistance. LPS triggers facilitatation to recruit macrophages into adipose tissue, and activates macrophages and adipocytes via TLR4 to induce local inflammation in adipose tissues. Under this condition, macrophages increase lipolysis through the release of proinflammatory cytokines to produce free fatty acids (FFAs). FFAs are delivered and accumulated in distant organs such as the liver and skeletal muscle, which can induce inflammation via TLR4, leading to insulin resistance. Among these FFAs, saturated FAs act as a ligand for TLR4 in both macrophages and adipocytes to increase the secretion of proinflammatory cytokines, which also contribute to insulin resistance. Additionally, insulin resistance at adipose tissue increases lipolysis, leading to increased release of FFAs. At the same time, oxidized low-density lipoprotein (LDL) is produced by oxidative stress induced by metabolic endotoxemia, and also activates TLR4 to produce proinflammatory cytokines, which is associated with insulin resistance. Thus, insulin resistance and inflammation cause a vicious cycle to induce each other via TLR4.

  • Association Between Psychosocial Disorders and Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis

    Forest plot of the associations between gastroesophageal reflux disease and psychosocial disorders.

  • Effect of Drinking Warm Water on Esophageal Preparation Before Peroral Endoscopic Myotomy in Patients With Achalasia

    Representative case of different endoscopic preparation grades for patients with achalasia.

  • Esophageal Microbiota and Nutritional Intakes in Patients With Achalasia Before and After Peroral Endoscopic Myotomy

    Differences in alpha and beta diversity in esophageal microbiome (A) alpha diversity (Shannon index) and (B) beta diversity (Bray-Curtis index) The alpha diversity presented as Shannon index. Each dot represents an individual sample. Pink bars represent pre-peroral endoscopic myotomy (POEM), fluid; green bars represent post-POEM, fluid; blue bars represent pre-POEM, tissue; and purple bars represent post-POEM, tissue. Data are presented as box-and-whisker plots, with whiskers representing the lowest and highest values within 1.5*interquartile range (IQR). Black diamonds indicates the mean of Shannon index. *P < 0.05 as determined by two-way ANOVA followed by Tukey’s post hoc test.

  • Self-reported Non-celiac Gluten Sensitivity in the Korean Population: Demographic and Clinical Characteristics

    Prevalence of non-celiac gluten sensitivity (NCGS) in Korea via the survey: do you think eating food containing flour/wheat affects the occurrence of gastrointestinal symptoms? IBS, irritable bowel syndrome; VAS, visual analog scale.

  • Transanal Irrigation for Neurogenic Bowel Dysfunction in Multiple Sclerosis: A Retrospective Study

    Evolution of the neurogenic bowel dysfunction (NBD) score before and after transanal irrigation in 4 specific initial NBD categories. “Very minor group” is defined by NBD score ranged from 0 to 6, “Minor group” is defined by score ranging from 7 to 9, “Moderate group” is defined by score ranging from 10 to 13, “Severe group” is defined by NBD score ranging from 14 to 27. Red boxes correspond to the analyzed groups.


J Neurogastroenterol Motil 2022; 28(2): 167~334 Total PDF
Editorials
A Step Toward Discovering the New World of Esophageal Microbiota
Chan Hyuk Park
J Neurogastroenterol Motil 2022; 28(2): 167-168  https://doi.org/10.5056/jnm22021
Three-dimensional High-resolution Anorectal Manometry Is Never Like the Last Conventional Anorectal Manometry?
Tae Hee Lee
J Neurogastroenterol Motil 2022; 28(2): 169-170  https://doi.org/10.5056/jnm22024
How Does Drinking Warm Water Affect Esophageal Preparation Before Peroral Endoscopic Myotomy in Patients With Achalasia?
Cheol Min Shin
J Neurogastroenterol Motil 2022; 28(2): 171-172  https://doi.org/10.5056/jnm22025
Reviews and Meta-analysess
Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor–Toll-like Receptor 4–Proinflammatory Cytokine Signaling
Tsukasa Nozu and Toshikatsu Okumura
J Neurogastroenterol Motil 2022; 28(2): 173-184  https://doi.org/10.5056/jnm21002
Functional Neuroimaging in Irritable Bowel Syndrome: A Systematic Review Highlights Common Brain Alterations With Functional Movement Disorders
Veronica Nisticò, Roberta E Rossi, Andrea M D’Arrigo, Alberto Priori, Orsola Gambini, and Benedetta Demartini
J Neurogastroenterol Motil 2022; 28(2): 185-203  https://doi.org/10.5056/jnm21079
Clinical Trials of Probiotics in Patients With Irritable Bowel Syndrome: Some Points to Consider
Eamonn M M Quigley
J Neurogastroenterol Motil 2022; 28(2): 204-211  https://doi.org/10.5056/jnm22012
Association Between Psychosocial Disorders and Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis
Meijun He, Qun Wang, Da Yao, Jing Li, and Guang Bai
J Neurogastroenterol Motil 2022; 28(2): 212-221  https://doi.org/10.5056/jnm21044
Original Articles
Development of Dilated Esophagus, Sigmoid Esophagus, and Esophageal Diverticulum in Patients With Achalasia: Japan Achalasia Multicenter Study
Hiroki Sato, Yusuke Fujiyoshi, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Shuji Terai, and Haruhiro Inoue
J Neurogastroenterol Motil 2022; 28(2): 222-230  https://doi.org/10.5056/jnm21188
Effect of Drinking Warm Water on Esophageal Preparation Before Peroral Endoscopic Myotomy in Patients With Achalasia
Hong Jin Yoon, Young Hoon Youn, Sung Hwan Yoo, Seyeon Jeon, and Hyojin Park
J Neurogastroenterol Motil 2022; 28(2): 231-236  https://doi.org/10.5056/jnm21119
Esophageal Microbiota and Nutritional Intakes in Patients With Achalasia Before and After Peroral Endoscopic Myotomy
Da Hyun Jung, Young Hoon Youn, Do Hoon Kim, Chul-Hyun Lim, Hee-Sook Lim, Hee Seok Moon, Ju Yup Lee, Hyojin Park, and Su Jin Hong
J Neurogastroenterol Motil 2022; 28(2): 237-246  https://doi.org/10.5056/jnm21057
Adverse Events Associated With Peroral Endoscopic Myotomy Affecting Extended Hospital Stay: A Multi-center Retrospective Study in South Korea
Ju Yup Lee, Chul-Hyun Lim, Do Hoon Kim, Hwoon-Yong Jung, Young Hoon Youn, Da Hyun Jung, Jun Chul Park, Hee Seok Moon, and Su Jin Hong; Therapeutic Endoscopy and Instrument for Functional Gastrointestinal Disorders Study Group Under the Korean Society of Neurogastroenterology and Motility
J Neurogastroenterol Motil 2022; 28(2): 247-254  https://doi.org/10.5056/jnm21081
Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia
Shaoqi Duan, Nobuko Imamura, Takashi Kondo, Hirosato Kanda, Yoko Kogure, Takuya Okugawa, Masashi Fukushima, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui, Koichi Noguchi, Yi Dai, and Hiroto Miwa
J Neurogastroenterol Motil 2022; 28(2): 255-264  https://doi.org/10.5056/jnm21204
A Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of DA-9701 (Motilitone) in Patients With Constipation-type Irritable Bowel Syndrome and Functional Dyspepsia Overlap: A Pilot Study
Ju Yup Lee, Nayoung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, and Dong Ho Lee
J Neurogastroenterol Motil 2022; 28(2): 265-275  https://doi.org/10.5056/jnm20236
Association Between Body Mass Index and Functional Dyspepsia in Young Japanese People
Yasunori Yamamoto, Shinya Furukawa, Junichi Watanabe, Aki Kato, Katsunori Kusumoto, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Katsuhiko Kohara, Yuka Saeki, and Yoichi Hiasa
J Neurogastroenterol Motil 2022; 28(2): 276-282  https://doi.org/10.5056/jnm21076
Self-reported Non-celiac Gluten Sensitivity in the Korean Population: Demographic and Clinical Characteristics
Ra Ri Cha, Jeong Hwan Kim, Hoon Sup Koo, Kee Wook Jung, Yang Won Min, Chang Hwan Choi, Han Seung Ryu, Yong Hwan Kwon, Dae Hyeon Cho, Joong Goo Kwon, Kyung Sik Park, and Hyun Jin Kim
J Neurogastroenterol Motil 2022; 28(2): 283-290  https://doi.org/10.5056/jnm21108
Overlap Between Constipation and Gastroesophageal Reflux Disease in Japan: Results From an Internet Survey
Naotaka Ogasawara,* Yasushi Funaki, Kunio Kasugai, Masahide Ebi, Yasuhiro Tamura, Shinya Izawa, and Makoto Sasaki
J Neurogastroenterol Motil 2022; 28(2): 291-302  https://doi.org/10.5056/jnm21065
Three-dimensional High-resolution Anorectal Manometry in Children With Non-retentive Fecal Incontinence
Marcin Banasiuk,* Marcin Dziekiewicz, Magdalena Dobrowolska, Barbara Skowrońska, Łukasz Dembiński, and Aleksandra Banaszkiewicz
J Neurogastroenterol Motil 2022; 28(2): 303-311  https://doi.org/10.5056/jnm20216
Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial
Desiree F Baaleman, Mana H Vriesman, Ilan J N Koppen, Kim M Osborne, Marc A Benninga, Miguel Saps, Desale Yacob, Peter L Lu, Frederick W Woodley, and Carlo Di Lorenzo
J Neurogastroenterol Motil 2022; 28(2): 312-319  https://doi.org/10.5056/jnm20274
Transanal Irrigation for Neurogenic Bowel Dysfunction in Multiple Sclerosis: A Retrospective Study
Maëlys Teng, Gabriel Miget, Mirella Moutounaïck, Florian Kervinio, Audrey Charlanes, Camille Chesnel, Frédérique Le Breton, and Gérard Amarenco
J Neurogastroenterol Motil 2022; 28(2): 320-326  https://doi.org/10.5056/jnm19040
Letter to the Editor
A Case of Sprue-like Enteropathy Associated With Valsartan and Irbesartan
Seo Yeon Yoo, Jihun Kim, and Kee Wook Jung
J Neurogastroenterol Motil 2022; 28(2): 327-329  https://doi.org/10.5056/jnm21161
A New Analysis for Old Problem of Bile Reflux
Chun Yao, Linlin Liu, Meng Xia, and Jianlin Lv
J Neurogastroenterol Motil 2022; 28(2): 330-331  https://doi.org/10.5056/jnm21207
Sexual Dimorphism in the Gut Microbiome: Microgenderome or Microsexome?
Agata Mulak, Muriel Larauche, and Yvette Taché
J Neurogastroenterol Motil 2022; 28(2): 332-333  https://doi.org/10.5056/jnm21242
Sexual Dimorphism in the Gut Microbiome: Microgenderome or Microsexome? Author’s Reply
Nayoung Kim
J Neurogastroenterol Motil 2022; 28(2): 334-334  https://doi.org/10.5056/jnm22007

e-submission

Current Issue

April 2022
Volume 28
Issue 2
  • News & Notice
  • Yu Kyung Cho
    Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary’s hospital, Seoul, Korea
    Kee Wook Jung
    Department of Gastroenterology,
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • Yong Sung Kim
    Digestive Disease Research Institute, School of Medicine, Wonkwang University and Sanbon Goodbreath Clinic
    Tadayuki Oshima
    Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
  • Haifeng Zheng
    Department of Physiology
    and Cell Biology, University of Nevada, Reno, School of Medicine, Nevada, USA
  • Official Journal of
  • Aims and Scope
  • Ethical Policies
The aim of the Journal is to foster and promote research activities on the area of the motor, sensory and functional disorders of gastrointestinal tract. The Journal provides researchers with accessible rooms for publication of their research results in the field of neuroga- stroenterology and motility. more

Indexed/Covered by

logo QR code


Neurogastroenterology and Motility Societies in the World