• Inflammation and Impaired Gut Physiology in Post-operative Ileus: Mechanisms and the Treatment Options

    Stepwise events involved in stress induced localized inflammation and barrier dysfunction. ➊ Stress induced autonomic nerve stimulation, release of peripheral corticotropin-releasing factor (CRF) and muscularis macrophages receptors activation, further strengthened by damage associated molecular patterns (DAMPs) mediated immune cells activation. ➋ Nuclear activation and release of pro-inflammatory chemokines and cytokines. ➌ Upregulation of intercellular adhesion molecules-1 (ICAM-1) in the endothelial cells of blood vessels. ➍ Influx of leukocytes in the muscularis. ➎ Increase synthesis of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) enzymes in the muscularis resident macrophages, release of inflammatory substances (prostaglandins [PGs] and nitric oxide [NO]) in the muscularis to cause localized inflammation. ➏ Mast cell and cortisol mediated barrier disruption cause translocation of luminal antigens (lipopolysaccharide [LPS]). ➐ LPS induce pathogen associated molecular patterns (PAMPs) mediated activation of mucosal immune cells to further exacerbate inflammation. ➑ The luminal antigen drainage through lymphatics and activation of dendritic cells along activation of inhibitory sympathetic and vagal nerve cause generalized inflammation through gastrointestinal tract to induce post-operative ileus. Th, T helper cells; MM, muscularis macrophages; MCP-1, monocyte chemoattractant protein-1; MIP-1α, macrophage inflammatory protein-1α; SM, smooth muscle; LM, longitudinal muscle.

  • Concise Review: Applicability of High-resolution Manometry in Gastroesophageal Reflux Disease

    Metrics from esophageal high-resolution manometry used in the evaluation of contraction reserve. (A) The vigor of esophageal body contraction is assessed using the distal contractile integral (DCI). (B) The vigor of esophageal body contraction following inhibition of peristalsis during the repetitive swallows by multiple rapid swallows (MRS) provocative test. The DCI of contraction following MRS is higher than the mean DCI from test swallows (post-MRS: wet swallow DCI ratio > 1) indicates contraction reserve.

  • Estimating Probability for Esophageal Obstruction: A Diagnostic Decision Support Tool Applying Machine Learning to Functional Lumen Imaging Probe Panometry

    Probability for esophagogastric junction (EGJ) obstruction using functional lumen imaging probe (FLIP) panometry metrics. Four patients (A-D) from the study cohort are plotted based on the EGJ-distensibility index (DI) and maximum EGJ-diameter from FLIP panometry as described in the text. Figure used with permission from the Esophageal Center of Northwestern (available from URL: https://www.wklytics.com/nmgi/prob_flip.html).

  • Predicting Responsiveness to Biofeedback Therapy Using High-resolution Anorectal Manometry With Integrated Pressurized Volume

    Four categories of integrated pressurized volumes (IPVs) from the rectum to the anal canal. (A) Categorization of the pressure signals during simulated evacuation from the rectum to the anus into 5 regions. (B-E) IPVs from the lower portion (blue), upper portion (red), and the IPV ratio.

  • Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial

    Biomarker identification of responders to probiotic treatment. The potential biomarkers identified by the linear discriminant analysis (LDA) effect size algorithm are shown with heatmaps of the log-scaled relative abundance. Each plot represents biomarkers of the responders and non-responders in the (A) pre-treatment samples and (B) post-treatment samples and (C) biomarkers of the pre- and post-treatment samples in the responder group.

  • Relationship Between Intestinal Slow-waves, Spike-bursts, and Motility, as Defined Through High-resolution Electrical and Video Mapping

    Simultaneous bioelectrical and video mapping method. (A) Arrangement of the cross-polarized camera setup and the electrode array on the intestine. Camera exposure is recorded along with the bioelectrical signals by the BioSemi ActiveTwo system for synchronization. (B) Flexible electrode array used for high-resolution (HR) bioelectrical mapping (16 × 8 configuration; 4 mm spacing). (C) Intestine as visible from the camera, placed over the flexible electrode array. LED, light emitting diode.


J Neurogastroenterol Motil 2022; 28(4): 509~710 Total PDF
Editorials
The Clinical Usefulness of Functional Luminal Imaging Probe in Esophageal Dysmotility Disorder
Kee Wook Jung
J Neurogastroenterol Motil 2022; 28(4): 509-511  https://doi.org/10.5056/jnm22135
Socioeconomic Disparities: A Possible Clue to a Puzzle Encompassing Organic to Functional Gastrointestinal Disorders
Yong Sung Kim and Suck Chei Choi
J Neurogastroenterol Motil 2022; 28(4): 512-514  https://doi.org/10.5056/jnm22156
Integrated Pressurized Volume, Promising Functional Anorectal Parameters
Seon-Young Park
J Neurogastroenterol Motil 2022; 28(4): 515-516  https://doi.org/10.5056/jnm22157
Reviews
Inflammation and Impaired Gut Physiology in Post-operative Ileus: Mechanisms and the Treatment Options
Zahid Hussain and Hyojin Park*
J Neurogastroenterol Motil 2022; 28(4): 517-530  https://doi.org/10.5056/jnm22100
Concise Review: Applicability of High-resolution Manometry in Gastroesophageal Reflux Disease
Sawangpong Jandee, Suriya Keeratichananont, Jan Tack, and Tim Vanuytsel
J Neurogastroenterol Motil 2022; 28(4): 531-539  https://doi.org/10.5056/jnm22082
The Role of Short Chain Fatty Acids in Irritable Bowel Syndrome
Wenxi Jiang, Jiali Wu, Shefeng Zhu, Linying Xin, Chaohui Yu, and Zhe Shen*
J Neurogastroenterol Motil 2022; 28(4): 540-548  https://doi.org/10.5056/jnm22093
Bile Acid and Gut Microbiota in Irritable Bowel Syndrome
Yang Won Min, Ali Rezaie, and Mark Pimentel
J Neurogastroenterol Motil 2022; 28(4): 549-561  https://doi.org/10.5056/jnm22129
Original Articles
Subtype of Achalasia and Integrated Relaxation Pressure Measured Using the Starlet High-resolution Manometry System: A Multicenter Study in Japan
Tetsuya Tatsuta, Hiroki Sato, Yusuke Fujiyoshi, Hirofumi Abe, Akio Shiwaku, Junya Shiota, Chiaki Sato, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Yuichiro Ikebuchi, Hiroshi Yokomichi, Shinsaku Fukuda, and Haruhiro Inoue
J Neurogastroenterol Motil 2022; 28(4): 562-571  https://doi.org/10.5056/jnm21254
Estimating Probability for Esophageal Obstruction: A Diagnostic Decision Support Tool Applying Machine Learning to Functional Lumen Imaging Probe Panometry
Jacob M Schauer, Wenjun Kou, Jacqueline E Prescott, Peter J Kahrilas, John E Pandolfino, and Dustin A Carlson
J Neurogastroenterol Motil 2022; 28(4): 572-579  https://doi.org/10.5056/jnm21239
Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index Could Identify Gastroesophageal Reflux Disease but pH-Impedance Metrics Alone Might Not Correlate With Proton Pump Inhibitor Response in Chinese Patients With Typical Reflux Symptoms
Dongke Wang, Chaofan Duan, Xiaohao Zhang, Junying Xu, Xiaohua Hou,* and Xuelian Xiang*
J Neurogastroenterol Motil 2022; 28(4): 580-588  https://doi.org/10.5056/jnm21156
Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden in Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility
Wei-Yi Lei, Shu-Wei Liang, Taher Omari, Wei-Chuan Chang, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Tso-Tsai Liu, Lin Lin, C Prakash Gyawali, and Chien-Lin Chen
J Neurogastroenterol Motil 2022; 28(4): 589-598  https://doi.org/10.5056/jnm21189
Clinical Implications of the Gastroesophageal Reflux Disease Questionnaire and Reflux Symptom Index in Patients With Suspected Laryngopharyngeal Reflux Symptoms
Young Dong Kim, Cheol Min Shin, Woo-Jin Jeong, Yang Jin Kim, Hyuk Yoon, Young Soo Park, Nayoung Kim, and Dong Ho Lee
J Neurogastroenterol Motil 2022; 28(4): 599-607  https://doi.org/10.5056/jnm21235
Predicting Responsiveness to Biofeedback Therapy Using High-resolution Anorectal Manometry With Integrated Pressurized Volume
Myeongsook Seo, Jiyoung Yoon, Kee Wook Jung, Segyeong Joo, Jungbok Lee, Kyung Min Choi, Hyo Jeong Lee, In Ja Yoon, Woojoo Noh, So Young Seo, Do Yeon Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, and Seung-Jae Myung
J Neurogastroenterol Motil 2022; 28(4): 608-617  https://doi.org/10.5056/jnm21137
Infantile Colic and the Subsequent Development of the Irritable Bowel Syndrome
Ju Hee Kim, Seung Won Lee, Yoowon Kwon, Eun Kyo Ha, Jaewoo An, Hye Ryeong Cha, Su Jin Jeong, and Man Yong Han
J Neurogastroenterol Motil 2022; 28(4): 618-629  https://doi.org/10.5056/jnm21181
Type of Rectal Barostat Protocol Affects Classification of Hypersensitivity and Prediction of Symptom Severity in Irritable Bowel Syndrome
Axel Josefsson, Hans Törnblom, and Magnus Simrén
J Neurogastroenterol Motil 2022; 28(4): 630-641  https://doi.org/10.5056/jnm21214
Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial
Seung Yong Shin, Sein Park, Jung Min Moon, Kisung Kim, Jeong Wook Kim, Jongsik Chun, Tae Hee Lee, and Chang Hwan Choi; The Microbiome Research Group of the Korean Society for Neurogastroenterology and Motility
J Neurogastroenterol Motil 2022; 28(4): 642-654  https://doi.org/10.5056/jnm21202
The Conundrum of Obesity and Gastroparesis Hospitalizations: A Retrospective Comparative Analysis of Hospitalization Characteristics and Disparities Amongst Socioeconomic and Racial Backgrounds in the United States
Dushyant S Dahiya, Sumant Inamdar, Abhilash Perisetti, Hemant Goyal, Amandeep Singh, Rajat Garg, Chin-I Cheng, Asim Kichloo, Mohammad Al-Haddad, and Neil Sharma
J Neurogastroenterol Motil 2022; 28(4): 655-663  https://doi.org/10.5056/jnm21232
Relationship Between Intestinal Slow-waves, Spike-bursts, and Motility, as Defined Through High-resolution Electrical and Video Mapping
Sachira Kuruppu, Leo K Cheng, Recep Avci, Timothy R Angeli-Gordon, and Nira Paskaranandavadivel
J Neurogastroenterol Motil 2022; 28(4): 664-677  https://doi.org/10.5056/jnm21183
Distribution and Function of Platelet-derived Growth Factor Receptor Alpha-positive Cells and Purinergic Neurotransmission in the Human Colon: Is It Different Between the Right and Left Colon?
Kil-yong Lee, Tae Sik Sung, Byoung H Koh, Seung-Bum Ryoo, Jung Nyeo Chun, Shin-Hye Kim, Kyu Joo Park, and Insuk So
J Neurogastroenterol Motil 2022; 28(4): 678-692  https://doi.org/10.5056/jnm21117
Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model
Satoshi Sugino, Ken Inoue, Reo Kobayashi, Ryohei Hirose, Toshifumi Doi, Akihito Harusato, Osamu Dohi, Naohisa Yoshida, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hiroaki Yasuda, Hideyuki Konishi, Yasuko Hirai, Katsura Mizushima, Yuji Naito, Toshifumi Tsuji, Takashi Okuda, Keizo Kagawa, Makoto Tominaga, and Yoshito Itoh
J Neurogastroenterol Motil 2022; 28(4): 693-705  https://doi.org/10.5056/jnm21198
Letter to the Editor
Narcotic Bowel Syndrome, an Under-recognized Cause of Chronic Abdominal Pain in Adults
Christian von Muhlenbrock, Paulina Nuñez, Rodrigo Quera, and Ana María Madrid
J Neurogastroenterol Motil 2022; 28(4): 706-708  https://doi.org/10.5056/jnm22114
A Case of Emetophobia Responding to Mirtazapine and Propranolol Treatment
Merve Köksal, Gökçe Koçak, Yusuf Öztürk, and Ali Evren Tufan
J Neurogastroenterol Motil 2022; 28(4): 709-710  https://doi.org/10.5056/jnm22133

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Current Issue

October 2022
Volume 28
Issue 4
  • News & Notice
  • Yu Kyung Cho
    Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary’s hospital, Seoul, Korea
    Kee Wook Jung
    Department of Gastroenterology,
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • Yong Sung Kim
    Digestive Disease Research Institute, School of Medicine, Wonkwang University and Sanbon Goodbreath Clinic
    Tadayuki Oshima
    Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
  • Haifeng Zheng
    Department of Physiology
    and Cell Biology, University of Nevada, Reno, School of Medicine, Nevada, USA
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The aim of the Journal is to foster and promote research activities on the area of the motor, sensory and functional disorders of gastrointestinal tract. The Journal provides researchers with accessible rooms for publication of their research results in the field of neuroga- stroenterology and motility. more

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