• How to Implement the 3-Phase FODMAP Diet Into Gastroenterological Practice

    Summary of the steps involved in the dietetic process of patients with irritable bowel syndrome (IBS). FODMAP, fermentable oligo-, di-, mono-saccharides, and polyols.

  • Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction

    Enterochromaffin (EC) cells dynamics in gut physiology and disorders of gut-brain interactions. (A) Heterogenous distribution of EC cells. (B-D) Functional heterogeneity of EC cells. Small intestine EC cells are specialized for sensing nutrients and colonic EC cells for gut microbiota and its derived molecules. (E, F) Apical and basolateral interface of EC cells. EC cells coordinate bilateral communication through crosstalk between dietary, microbial, and inflammatory factors to which their apical surface is exposed and to enteric neurons with afferent endings close to their basolateral surface, coordinating gut-brain communication. GI, gastrointestinal; Tph1, tryptophan hydroxylase 1; Lgr5, leucine-rich repeat-containing G-protein coupled receptor 5; 5-HT, 5-hydroxytryptamine; CCK, cholecystokinin; DGBI, disorders of gut-brian interaction; AHR, aryl hydrocarbon receptor; TRPA1, transient receptor potential ankyrin 1; TLR, toll-like receptor; OLF558, olfactory receptor 558; ST2, suppressing the tumorigenicity 2 receptor; TGR5, Takeda G protein-coupled receptor 5; FFARs, free fatty acid receptor genes; SERT, serotonin reuptake transporter; 5-HTR, 5-hydroxytryptamine receptor; IPAN, intrinsic primary afferent neuron; PDGFRα, platelet-derived growth factor receptor α; SMC, smooth muscle cell; ICC, interstitial cells of Cajal.

  • Efficacy of Slow Nutrient Drinking Test for Evaluating Postprandial Distress Symptom in Japanese Patients With Functional Dyspepsia

    The test ending time. (A) Scatter diagrams of the test ending time. (B) Rate of participants who passed each time point in both groups. Open columns indicate the group of healthy participants. Closed columns indicate the group of patients with functional dyspepsia (FD). ***P < 0.001.

  • The Upper Esophageal Sphincter Distensibility Index Measured Using Functional Lumen Imaging Probe Identifies Defective Barrier Function of the Upper Esophageal Sphincter

    Placement of functional lumen imaging probe (FLIP) catheter across upper esophageal sphincter (UES) and real-time data output is shown. CSA, cross-sectional area.

  • The Predictive Value of Intraoperative Esophageal Functional Luminal Imaging Probe Panometry in Patients With Achalasia Undergoing Peroral Endoscopic Myotomy: A Single-center Experience

    Process for the conversion of functional luminal imaging probe (FLIP) data to 3-dimensional panometry data. (A) Based on FLIP data obtained from each channel of the probe, the values of each channel are shown in a 2-dimensional plot. The x-axis shows the procedure time (second), and the y-axis shows the diameter (mm) of each channel. (B) The measured diameter data were used to convert FLIP data to 3-dimensional panometry data, and the diameter between each channel was interpolated by the spline method. The spline interpolation method performs interpolation by making interpolation functions of neighboring regions match not only the functional but also the differential value. The 3-dimensional contour plot was created using diameter values obtained through interpolation. (C) The 3-dimensional contour plot is colored according to the diameter. Depending on the diameter, the color changes from red to blue, and a few of the measured diameters less than 5 mm is set to black. (D) Creating 3-dimensional panometry data using the colored 3-dimensional contour plot from Figure 2A. (E) Dimension reduction of 3-dimensional panometry data into the 2-dimensional plot helps check the patient’s condition. (B to E) In each 3-dimensional plot, the x-axis represents the procedure time (second), the y-axis represents the probe channel, and the z-axis represents the diameter (mm) measured at the probe.

  • A Potential Role of Cholinergic Dysfunction on Impaired Colon Motility in Experimental Intestinal Chagas Disease

    Natural history and pathological anatomy of the murine megacolon. Control and infected groups were evaluated in the acute phase (AP; 11 days) and chronic phases (CP; 3, 7, 12, and 15 months post-infection [m.p.i]) of Trypanosoma cruzi infection. (A) control acute phase (CAP), (B) infected acute phase (IAP), (C) infected chronic phase 3 m.p.i. (ICP3), (D) infected chronic phase 7 m.p.i. (ICP7), (E) control chronic phase 12 m.p.i. (ICP12), (F) control chronic phase 15 m.p.i. (ICP15). For images (A) to (F), arrows: inflammatory infiltrate; asterisk: muscle degeneration; dashed line: thickness of the circular smooth muscle layer. Bar: 50 µm (10×) A, B, C, D, E, and F; 20 µm (20×) insert F. (G) Clinical score of the histopathological aspects of the control and the infected acute and chronic phases groups. (H) For each animal, the thickness of the muscular layer value was calculated from the average of 10 images in H&E (10× objective) (n = 5, for each group). For (H), statistical analysis: two-way ANOVA and Student–Newman–Keuls. Control (○); Infected (●). For (H), the symbols (*) represent differences to the group (control vs infected) and the letters represent the difference in the time, regarding the same group. aDifferent from AP (ie, ICP3, ICP7, ICP12, and ICP15 were different from IAP). P ≤ 0.05. Data presented as mean ± SD. (I) Macroscopic aspects of the megacolon of mice infected (ICP15) compared to control mice (CCP).


J Neurogastroenterol Motil 2022; 28(3): 335~507 Total PDF
Editorials
Irritable Bowel Syndrome or Psychiatric Disorders: Which Comes First?
Hong Sub Lee
J Neurogastroenterol Motil 2022; 28(3): 335-336  https://doi.org/10.5056/jnm22065
Eating Behavior in Functional Dyspepsia
Younghee Choe and Kyung Ho Song
J Neurogastroenterol Motil 2022; 28(3): 337-338  https://doi.org/10.5056/jnm22073
Role of Nutrient Drinking Test in Functional Dyspepsia
Hyun Deok Shin
J Neurogastroenterol Motil 2022; 28(3): 339-342  https://doi.org/10.5056/jnm22074
Reviews
How to Implement the 3-Phase FODMAP Diet Into Gastroenterological Practice
Nessmah Sultan, Jane E Varney, Emma P Halmos, Jessica R Biesiekierski, Chu K Yao, Jane G Muir, Peter R Gibson, and Caroline J Tuck
J Neurogastroenterol Motil 2022; 28(3): 343-356  https://doi.org/10.5056/jnm22035
Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction
Lai Wei, Rajan Singh, and Uday C Ghoshal
J Neurogastroenterol Motil 2022; 28(3): 357-375  https://doi.org/10.5056/jnm22008
Systematic Review
A Systematic Review of the Development and Psychometric Properties of Constipation-Related Patient-Reported Outcome Measures: Opportunities for Digital Health
V Vien Lee, Ni Yin Lau, David J Y Xi, Anh T L Truong, Agata Blasiak, Kewin T H Siah, and Dean Ho
J Neurogastroenterol Motil 2022; 28(3): 376-389  https://doi.org/10.5056/jnm22004
Original Articles
General Well-being and Coping Strategies in Adult Eosinophilic Esophagitis Patients
Willemijn E de Rooij, Floor Bennebroek Evertsz’, Aaltje Lei, and Albert J Bredenoord
J Neurogastroenterol Motil 2022; 28(3): 390-400  https://doi.org/10.5056/jnm21143
Normal Values of High-resolution Anorectal Manometry of Healthy Indians
Rahul Deshmukh, Akash Shukla, Sanjay Chandnani, Pravin M Rathi, Pratik Tibdewal, Shubham Jain, Nitin Ramani, Parmeshwar Junare, Partha Debnath, Leela Shinde, Asif Bagwan, and Megha Meshram
J Neurogastroenterol Motil 2022; 28(3): 401-408  https://doi.org/10.5056/jnm21107
Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer
Hye-Kyung Jung, Chung Hyun Tae, Hye Ah Lee, Ko Eun Lee, Chang Mo Moon, Seong Eun Kim, Ju Young Seoh, and Joo-Ho Lee
J Neurogastroenterol Motil 2022; 28(3): 409-417  https://doi.org/10.5056/jnm21145
Association Between Eating Behavior, Frequency of Meals, and Functional Dyspepsia in Young Japanese Population
Yasunori Yamamoto, Shinya Furukawa, Junichi Watanabe, Aki Kato, Katsunori Kusumoto, Teruki Miyake, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Katsuhiko Kohara, Syuichi Saheki, Yuka Saeki, and Yoichi Hiasa
J Neurogastroenterol Motil 2022; 28(3): 418-423  https://doi.org/10.5056/jnm21146
Efficacy of Slow Nutrient Drinking Test for Evaluating Postprandial Distress Symptom in Japanese Patients With Functional Dyspepsia
Takahiro Watanabe, Tatsuhiro Masaoka, Hisako Kameyama, and Takanori Kanai
J Neurogastroenterol Motil 2022; 28(3): 424-430  https://doi.org/10.5056/jnm21075
Safety and Efficacy of Elobixibat, an Ileal Bile Acid Transporter Inhibitor, in Elderly Patients With Chronic Idiopathic Constipation According to Administration Time: Interim Analysis of Post-marketing Surveillance
Atsushi Nakajima, Mio Fujimaki, Yuki Arai, and Kento Emori
J Neurogastroenterol Motil 2022; 28(3): 431-441  https://doi.org/10.5056/jnm20263
Risk Factors for Self-reported Irritable Bowel Syndrome With Prior Psychiatric Disorder: The Lifelines Cohort Study
Francis Creed
J Neurogastroenterol Motil 2022; 28(3): 442-453  https://doi.org/10.5056/jnm21041
Saccharomyces boulardii and Lactulose for Childhood Functional Constipation: A Multicenter Randomized Controlled Trial
Kyung Jae Lee, Eell Ryoo, Yoo Min Lee, Jung Min Yoon, Hyo-Jeong Jang, So Yoon Choi, You Jin Choi, Hyun Jin Kim, Ju Young Chung, and Jung Ok Shim
J Neurogastroenterol Motil 2022; 28(3): 454-462  https://doi.org/10.5056/jnm21130
The Upper Esophageal Sphincter Distensibility Index Measured Using Functional Lumen Imaging Probe Identifies Defective Barrier Function of the Upper Esophageal Sphincter
Lucie F Calderon, Meredith Kline, Marc Hersh, Kevin P Shah, Suprateek Kundu, Andrew Tkaczuk, Nancy McColloch, and Anand S Jain
J Neurogastroenterol Motil 2022; 28(3): 463-473  https://doi.org/10.5056/jnm21197
The Predictive Value of Intraoperative Esophageal Functional Luminal Imaging Probe Panometry in Patients With Achalasia Undergoing Peroral Endoscopic Myotomy: A Single-center Experience
Li-Chang Hsing, KyungMin Choi, Kee Wook Jung, Segyeong Joo, Nayoung Kim, Ga Hee Kim, Hee Kyong Na, Ji Yong Ahn, JeongHoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, and Hwoon-Yong Jung
J Neurogastroenterol Motil 2022; 28(3): 474-482  https://doi.org/10.5056/jnm21186
A Potential Role of Cholinergic Dysfunction on Impaired Colon Motility in Experimental Intestinal Chagas Disease
Mayra F Ricci, Samantha R Béla, Joana L Barbosa, Michele M Moraes, Ana L Mazzeti, Maria T Bahia, Laila S Horta, Helton da C Santiago, Jader S Cruz, Luciano dos S A Capettini, and Rosa M E Arantes
J Neurogastroenterol Motil 2022; 28(3): 483-500  https://doi.org/10.5056/jnm21074
Letter to the Editor
Comment to the Description of a Novel Cohesinopathy in Chronic Intestinal Pseudo Obstruction
Elena Bonora, Francesca Bianco, and Roberto De Giorgio
J Neurogastroenterol Motil 2022; 28(3): 501-502  https://doi.org/10.5056/jnm22017
Estimating the Self-reported Prevalence of Non-celiac Gluten Sensitivity in the Korean Population
Oscar G Figueroa-Salcido, Jesús G Arámburo-Gálvez, and Noé Ontiveros
J Neurogastroenterol Motil 2022; 28(3): 503-503  https://doi.org/10.5056/jnm22072
Non-celiac Gluten Sensitivity or Celiac Disease, This Is Still the Question
Gasparre Valentina, Zamparella Maria, and Francavilla Ruggiero
J Neurogastroenterol Motil 2022; 28(3): 504-505  https://doi.org/10.5056/jnm22075
Microbial Dysbiosis in Achalasia: Insights on How to Prevent Cancer
Vitor P Arienzo, Isabela R Sunye, and Francisco Tustumi
J Neurogastroenterol Motil 2022; 28(3): 506-507  https://doi.org/10.5056/jnm22076

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Current Issue

July 2022
Volume 28
Issue 3
  • News & Notice
  • Yu Kyung Cho
    Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary’s hospital, Seoul, Korea
    Kee Wook Jung
    Department of Gastroenterology,
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • Yong Sung Kim
    Digestive Disease Research Institute, School of Medicine, Wonkwang University and Sanbon Goodbreath Clinic
    Tadayuki Oshima
    Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
  • Haifeng Zheng
    Department of Physiology
    and Cell Biology, University of Nevada, Reno, School of Medicine, Nevada, USA
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The aim of the Journal is to foster and promote research activities on the area of the motor, sensory and functional disorders of gastrointestinal tract. The Journal provides researchers with accessible rooms for publication of their research results in the field of neuroga- stroenterology and motility. more

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