• Roles of Sex Hormones and Gender in the Gut Microbiota

    Molecular pathway of estrogen receptor (ER) action. Typically, estrogen binds to the ligand-binding domain of receptors in the nucleus, which causes a conformational change. Estrogen-responsive elements (ERE) mediate genomic effects. RE, response element; TF, transcription factor; GF, growth factor; GF-R, growth factor receptor; CoA, co-activator; CoR, co-repressor; MAPK, mictogen-activated protein kinase; PI3K, phophoinositide 3-kinase; Src, proto-oncogene tyrosine-protein kinase; AP-1, activating protein-1; Sp-1, stimulating protein-1. Adapted from Nie et al.16

  • Variations in Clinical Practice of Esophageal High-resolution Manometry: A Nationwide Survey

    Measurement parameters utilized to determine the esophageal motor function. (A) Esophagogastric junction (EGJ). (B) Esophageal body. EGJ-CI, esophagogastric junction-contractile integral; IRP, integrated relaxation pressure; LES, lower esophageal sphincter.

  • Normal Values of High-resolution Manometry Parameters With Provocative Maneuvers

    High-resolution manometry test swallows and maneuvers. (A) Supine 5 mL liquid; (B) upright 5 mL liquid; (C) viscous (apple sauce); (D) solid (graham cracker); (E) multiple rapid swallow; and (F) rapid drink challenge. Integrated relaxation pressure (IRP) and distal contractile integral (DCI) were 11 mmHg and 1760 mmHg·cm·sec (A), 8 mmHg and 1950 mmHg·cm·sec (B), 7 mmHg and 1600 mmHg·cm·sec (C), 10 mmHg and 1400 mmHg·cm·sec (D), 4 mmHg and 4600 mmHg·cm·sec (E), and 3 mmHg and 0 mmHg·cm·sec (F), respectively. Figure used with permission from the Esophageal Center at Northwestern.

  • Rectosigmoid Localization of Radiopaque Markers for Identifying Defecation Disorders in Patients With Chronic Constipation: A Retrospective Cohort Study

    Our diagnostic algorithm of defecation disorders using a colonic transit study. DD, defecation disorders; DRE, digital rectal examination; NTC, normal transit constipation; STC, slow transit constipation; RS, rectosigmoid colon.

  • Inter-hemispheric Functional Connections Are More Vulnerable to Attack Than Structural Connection in Patients With Irritable Bowel Syndrome

    Statistical maps showing voxel-mirrored homotopic connectivity (VMHC) differences between irritable bowel syndrome (IBS) and healthy controls (HCs; P < 0.05, corrected with Alphasim). IBS patients showed much higher VMHC in superior occipital gyrus, middle occipital gyrus, precuneus, posterior cingulate gyrus, and angular gyrus (red), while lower in supplementary motor area (blue). The color bar indicates the T-value from t test between groups.

J Neurogastroenterol Motil 2021; 27(4): 445~659 Total PDF
Is There a Way to Differentiate Esophageal Motility Disorders in Patients With Heartburn?
Sung Eun Kim
J Neurogastroenterol Motil 2021; 27(4): 445-447  https://doi.org/10.5056/jnm21173
Risk of Pyogenic Liver Abscess in Proton Pump Inhibitor Users: New Inventory of Proton Pump Inhibitor Induced Complications?
Ki Bae Bang
J Neurogastroenterol Motil 2021; 27(4): 448-450  https://doi.org/10.5056/jnm21177
Are Peri-operative Inflammatory Markers Useful in Predicting Post-operative Ileus?
Jung Ho Park
J Neurogastroenterol Motil 2021; 27(4): 451-452  https://doi.org/10.5056/jnm21174
2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease
Hye-Kyung Jung, Chung Hyun Tae, Kyung Ho Song, Seung Joo Kang, Jong Kyu Park, Eun Jeong Gong, Jeong Eun Shin, Hyun Chul Lim, Sang Kil Lee, Da Hyun Jung, Yoon Jin Choi, Seung In Seo, Joon Sung Kim, Jung Min Lee, Beom Jin Kim, Sun Hyung Kang, Chan Hyuk Park, Suck Chei Choi, Joong Goo Kwon, Kyung Sik Park, Moo In Park, Tae Hee Lee, Seung Young Kim, Young Sin Cho, Han Hong Lee, Kee Wook Jung, Do Hoon Kim, Hee Seok Moon, Hirota Miwa, Chien-Lin Chen, Sutep Gonlachanvit, Uday C Ghoshal, Justin C Y Wu, Kewin T H Siah, Xiaohua Hou, Tadayuki Oshima, Mi-Young Choi, and Kwang Jae Lee; The Korean Society of Neurogastroenterology and Motility
J Neurogastroenterol Motil 2021; 27(4): 453-481  https://doi.org/10.5056/jnm21077
Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine
Léa LenglarT, Caroline Caula, Thomas Moulding, Annabel Lyles, Delphine Wohrer, and Luigi Titomanlio
J Neurogastroenterol Motil 2021; 27(4): 482-494  https://doi.org/10.5056/jnm20290
Systematic Review
Medical Management of Constipation in Elderly Patients: Systematic Review
Seung Joo Kang, Young Sin Cho, Tae Hee Lee, Seong-Eun Kim, Han Seung Ryu, Jung-Wook Kim, Seon-Young Park, Yoo Jin Lee, and Jeong Eun Shin; Constipation Research Group of the Korean Society of Neurogastroenterology and Motility
J Neurogastroenterol Motil 2021; 27(4): 495-512  https://doi.org/10.5056/jnm20210
Technique Review
Pitfalls in the Interpretation of Chicago Classification for Esophageal Motility Disorders
Fernando A M Herbella, Francisco Schlottmann, and Marco G Patti
J Neurogastroenterol Motil 2021; 27(4): 513-517  https://doi.org/10.5056/jnm20058
Original Articles
Comparative Analysis of Relaxation Time Interval and Integrated Relaxation Pressure as Risk Factors for Aspiration in Patients With Oropharyngeal Dysphagia
Jung Ho Park, Chong-Il Sohn, Kyung Jae Yoon, and Jung Hwan Park
J Neurogastroenterol Motil 2021; 27(4): 518-524  https://doi.org/10.5056/jnm20049
Esophageal Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Identifying Proton Pump Inhibitor-refractory Non-erosive Reflux Disease
Yan Wang, Bixing Ye, Meifeng Wang, Lin Lin, and Liuqin Jiang
J Neurogastroenterol Motil 2021; 27(4): 525-532  https://doi.org/10.5056/jnm20073
Diagnostic Yield of High-resolution Esophageal Manometry With Chicago Classification Version 3.0 in Thai Patients
Sawangpong Jandee and Kasemsak Jandee
J Neurogastroenterol Motil 2021; 27(4): 533-539  https://doi.org/10.5056/jnm20088
Symptom Severity Related With Contraction Peaks in Patients With Jackhammer Esophagus
Yinglian Xiao, Dustin A Carlson, and John E Pandolfino
J Neurogastroenterol Motil 2021; 27(4): 540-544  https://doi.org/10.5056/jnm20229
Clinical Characteristics of Esophageal Motility Disorders in Patients With Heartburn
Satsuki Takahashi, Tomoaki Matsumura, Tatsuya Kaneko, Mamoru Tokunaga, Hirotaka Oura, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Naoki Akizue, Yuki Ohta, Atsuko Kikuchi, Mai Fujie, Keiko Saito, Kenichiro Okimoto, Daisuke Maruoka, Tomoo Nakagawa, Makoto Arai, Jun Kato, and Naoya Kato
J Neurogastroenterol Motil 2021; 27(4): 545-554  https://doi.org/10.5056/jnm20131
Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study
Joo Hyun Oh, Danbee Kang, Wonseok Kang, Eliseo Guallar, Juhee Cho, and Yang Won Min
J Neurogastroenterol Motil 2021; 27(4): 555-564  https://doi.org/10.5056/jnm20221
Patients With Definite and Inconclusive Evidence of Reflux According to Lyon Consensus Display Similar Motility and Esophagogastric Junction Characteristics
Mentore Ribolsi, Edoardo Savarino, Benjamin Rogers, Arvind Rengarajan, Marco Della Coletta, Matteo Ghisa, Michele Cicala, and C Prakash Gyawali
J Neurogastroenterol Motil 2021; 27(4): 565-573  https://doi.org/10.5056/jnm20158
Perceived Gastrointestinal Symptoms and Association With Meals in a French Cohort of Patients With Irritable Bowel Syndrome
Chloé Melchior, Simon Fremaux, Pauline Jouët, Gilles Macaigne, Jean-Jacques Raynaud, Suzelle Facon, Franck Iglicki, Yannick Taes, and Jean-Marc Sabate
J Neurogastroenterol Motil 2021; 27(4): 574-580  https://doi.org/10.5056/jnm20201
Heartburn, Functional Dyspepsia, Anxiety/Depression, and Sleep Disturbances Are Associated With Clinically Significant Belching
Yasuhiro Fujiwara, Masatsugu Okuyama, Yasuaki Nagami, Koichi Taira, Hirotaka Ishizu, Osamu Takaishi, Hiroshi Sato, and Toshio Watanabe
J Neurogastroenterol Motil 2021; 27(4): 581-587  https://doi.org/10.5056/jnm20225
Peri-operative Inflammatory Marker as a Predictive Factor for Prolonged Post-operative Ileus After Gastrectomy for Gastric Cancer
Yonsoo Kim, Young Min Kim, Jie-Hyun Kim, Young Hoon Youn, Jong Won Kim, and Hyojin Park
J Neurogastroenterol Motil 2021; 27(4): 588-595  https://doi.org/10.5056/jnm20203
Self-reported Wheat Sensitivity in Irritable Bowel Syndrome and Healthy Subjects: Prevalence of Celiac Markers and Response to Wheat-free Diet
Pavan Dhoble, Philip Abraham, Devendra Desai, Anand Joshi, Tarun Gupta, Shachish Doctor, Anand Deshpande, and Rajeshwari Basavanna
J Neurogastroenterol Motil 2021; 27(4): 596-601  https://doi.org/10.5056/jnm20086
Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life
Sayuri Yamamoto, Yurika Kawamura, Kazuhiro Yamamoto, Yoshiharu Yamaguchi, Yasuhiro Tamura, Shinya Izawa, Hiroaki Nakagawa, Yoshinori Wakita, Yasutaka Hijikata, Masahide Ebi, Yasushi Funaki, Wataru Ohashi, Naotaka Ogasawara, Makoto Sasaki, Masato Maekawa, and Kunio Kasugai
J Neurogastroenterol Motil 2021; 27(4): 602-611  https://doi.org/10.5056/jnm20135
A Pilot Study of Clinical Evaluation and Formation Mechanism of Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease Patients in Remission
Haiyang Wang, Xiaojing Zhao, Xiufang Cui, Meifeng Wang, Chunhua Jiao, Jiajia Li, Yan Yang, Yi Li, and Hongjie Zhang
J Neurogastroenterol Motil 2021; 27(4): 612-625  https://doi.org/10.5056/jnm20151
Can We Rely on the Rome IV Questionnaire to Diagnose Children With Functional Gastrointestinal Disorders?
Desiree F Baaleman, Carlos A Velasco-Benítez, Laura M Méndez-Guzmán, Marc A Benninga, and Miguel Saps
J Neurogastroenterol Motil 2021; 27(4): 626-631  https://doi.org/10.5056/jnm20179
Paradoxical Stimulatory Response of Remanent Sphincter of Oddi to Buscapina After Endoscopic Sphincterotomy
Zoltán Berger and Ana María Madrid S
J Neurogastroenterol Motil 2021; 27(4): 632-638  https://doi.org/10.5056/jnm20180
Altered Intestinal Permeability and Drug Repositioning in a Post-operative Ileus Guinea Pig Model
Young Min Kim, Zahid Hussain, Young Ju Lee, and Hyojin Park*
J Neurogastroenterol Motil 2021; 27(4): 639-649  https://doi.org/10.5056/jnm21018
Letter to the Editor
Cognitive Deficits Associated With Dysphagia in Patients With Dementia
Sun-Wung Hsieh, Hui-Yu Chuang, Chih-Hsing Hung, and Chun-Hung Chen
J Neurogastroenterol Motil 2021; 27(4): 650-652  https://doi.org/10.5056/jnm21027
Impact of Helicobacter pylori-related Microbial Dysbiosis in the Pathogenesis of Metabolic Syndrome and Gastrointestinal Dysmotility Disorders
Jannis Kountouras, Apostolis Papaefthymiou, Stergios A Polyzos, Elisabeth Vardaka, Marina Boziki, Anthony Kyriakopoulos, Fotios Sampsonas, George Agrotis, Kyriaki Karafyllidou, and Michael Doulberis
J Neurogastroenterol Motil 2021; 27(4): 653-654  https://doi.org/10.5056/jnm21059
Neuromodulators Are Effective for Treatment of Spastic Chest Pain After Heller Myotomy for Achalasia
Manik Aggarwal, John McMichael, Sudish C Murthy, Siva Raja, and Scott L Gabbard
J Neurogastroenterol Motil 2021; 27(4): 655-656  https://doi.org/10.5056/jnm21113
Association Between Visceral Hypersensitivity in Irritable Bowel Syndrome, Intestinal Microbiota, and Mast Cells: How to Detect Mast Cells Using Confocal Microscopy
Kang Nyeong Lee, Jiwon Lee, Juil Hwang, Chungha Lee, Ji Sook Kim, Seok Ho Song, Oh Young Lee, and Kwang-Geol Lee
J Neurogastroenterol Motil 2021; 27(4): 657-659  https://doi.org/10.5056/jnm21132


Current Issue

October 2021
Volume 27
Issue 4
  • News & Notice
  • Tae Hee Lee
    Institute for Digestive Research, Soonchunhyang University Seoul Hospital, Seoul, Korea
    Yu Kyung Cho
    Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary’s hospital, Seoul, Korea
  • Jung Ho Park
    Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  • Kewin T H Siah
    Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore
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The aim of the Journal is to foster and promote research activities on the area of the motor, sensory and functional disorders of gastrointestinal tract. The Journal provides researchers with accessible rooms for publication of their research results in the field of neuroga- stroenterology and motility. more

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