2023 Impact Factor
2023 Impact Factor
Mechanisms of gastrointestinal motility modulation in diabetic gastroparesis. The destruction and disappearance of interstitial cells of Cajal (ICC), abnormal levels of hormones in the gut-brain axis that affect gastric function and mitochondrial oxidative stress disorder leads to gastrointestinal dysfunction and produces gastroparesis. 5-HT, 5-hydroxytryptamine; CCK, cholecystokinin; SST, somatostatin; ROS, reactive oxygen species; SMCs, smooth muscle cells.
Intramuscular collagen staining is significantly increased in the circular smooth muscle (CSM) layer of the esophagus in achalasia. (A-C) Representative images of histochemistry for detection of collagen using Sirius Red/Fast Green staining, in sections of control esophagus (A), type 1 achalasia (B) and type 3 achalasia (C). The type 3 pattern was typically more aberrant than the other subtypes of achalasia. Arrows indicate regions of red staining (collagen) among the smooth muscle cells (intracellular regions, green). Scale bar, 50 µm. (D) Outcome of image analyses showing increased amount of collagen in achalasia, expressed as % total area of control or biopsy CSM sections. *P < 0.01 vs control. (E) Image analysis showing that the relative amounts of collagen were similar among the individual subtypes of achalasia.
Retrograde cricopharyngeus dysfunction patient: gas reflux events (arrows) not triggering upper esophageal sphincter relaxation and followed by secondary peristalsis.
The profiles of the glucose breath test before and after treatment: hydrogen (H2) concentrations in rifaximin group (A) and rifaximin plus trimebutine maleate group (B); methane (CH4) concentrations in rifaximin group (C) and rifaximin plus trimebutine maleate group (D).
ppm, parts per million.
The association between number of allergy diseases and the prevalence of functional gastrointestinal disorders. FD, functional dyspepsia; IBS, irritable bowel syndrome.
J Neurogastroenterol Motil 2024; 30(3): 253~380 
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