Supplementary Figure 7. Forest plot of sensitivity and specificity in a trial of proton pump inhibitors.
Gastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate into the esophagus or beyond, resulting in either troublesome symptoms or complications. GERD is heterogeneous in terms of varied manifestations, test findings, and treatment responsiveness. GERD diagnosis can be established wit ...
Hierarchization of diagnosis according to the Chicago classification version 3.0. Reproduced with permission from Kahrilas et al.1 IRP, integrated relaxation pressure; ULN, upper limit of normal; PEP, panesophageal pressurization; DL, distal latency; EGJ, esophagogastric junction morphology; DCI, distal contractile integral; IEM, ineffective esophageal motility.
Comparison of the width of intercellular space among (A) functional heartburn (FH), (B) non-erosive reflux disease (NERD)/proton pump inhibitor (PPI) responders, (C) NERD/PPI non responders, and width of intercellular spaces in all groups (D). **
Expression of mast cell tryptase in the control, post-operative ileus (POI), and ketotifen groups. (A) The average intensity of the expression of calprotectin was analyzed via MetaMorph microscopy automation. Representative immunohistochemical staining of mast cell tryptase for POI at 3 hours after the operation (POI 3H) (B) and POI at 6 hours after the operation (POI 6H) (C). Bars indicate the mean ± SEM (control group, n = 7; POI group, n = 7; ketotifen group, n = 7). *