• Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia

    The possible inflammatory and immune activation in gastrointestinal mucosa of patients with post-infectious irritable bowel syndrome–functional dyspepsia. Inflammatory cells (mast cells, eosinophils, T lymphocytes, and chromaffin cells) are activated and release inflammatory factors (TNF-α, IFN-γ, IL-1/6/8, etc) and inflammatory mediators (histamine, leukotriene, platelet activating factor, 5-hydroxytryptamine [5-HT], etc) to participate in the inflammatory response, resulting in the increase of epithelial permeability through the redistribution of tight junction proteins and visceral hypersensitivity through 5-HT and increased excitability of afferent neurons. MLCK, myosin light chain kinase; HPA, hypothalamic-pituitary-adrenal; ZO-1, zonula occludens-1; DRG, dorsal root ganglion.

  • Usefulness of Endoscopic Hill Grade in Evaluating Children Suspected of Having Gastroesophageal Reflux Disease

    Hill grade on endoscopy. Grade I: presence of a prominent fold of tissue closely approximated to the shaft of the endoscope. Grade II: the fold of tissue is less prominent and there are occasional periods of opening and rapid closing around the endoscope with respiration. Grade III: the fold is barely present, and the endoscope is not tightly gripped by the tissues. Grade IV: there is no fold, and the lumen of the esophagus is open, often allowing the squamous epithelium to be viewed from below. A hiatal hernia is always present.

  • Simultaneous Evaluation of Laryngopharyngeal Reflux and Swallowing Function Using Hypopharyngeal Multichannel Intraluminal Impedance Measurements in Neurologically Impaired Patients

    Hypopharyngeal multichannel intraluminal impedance and pH (HMII-pH) waveform showing no laryngopharyngeal reflux event and very low impedance baseline value in the hypopharyngeal channel. BI, baseline impedance.

  • Esophageal Motility Patterns After Peroral Endoscopic Myotomy in Patients With Achalasia

    Examples of high-resolution manometry (HRM) findings before and after peroral endoscopic myotomy (POEM). (A) Type I achalasia before POEM (left) with integrated relaxation pressure (IRP) 21.5 mmHg, ineffective esophageal motility (peristaltic recovery) after POEM with IRP 10.6 mmHg (right). (B) Type II achalasia before POEM (left) with IRP 32.8 mmHg, ineffective esophageal motility (peristaltic recovery) after POEM with IRP 11.7 mmHg (right). (C) Type II achalasia before POEM (left) with IRP 46.4 mmHg, ineffective esophageal motility (peristaltic recovery) after POEM with IRP 12.5 mmHg (right). (D) Type II achalasia before POEM with IRP 43.0 mmHg (left), absent contractility after POEM with IRP 14.0 mmHg (right). (E) Type II achalasia before POEM with IRP 27.3 mmHg (left), ineffective esophageal motility (peristaltic recovery) after POEM with IRP 10.8 mmHg (right). (F) Type III achalasia before POEM with IRP 30.8 mmHg (left), fragmented peristalsis after POEM with IRP 12.7 mmHg (right).


J Neurogastroenterol Motil 2021; 27(2): 149~306 Total PDF
Editorials
What Is the Difference in Characteristics Between Belching Disorder and Gastroesophageal Reflux Disease With Belching? Centering Around Supragastric Belching
Sung Eun Kim
J Neurogastroenterol Motil 2021; 27(2): 149-150  https://doi.org/10.5056/jnm21032
Integrated Relaxation Pressure During Swallowing: An Ever-changing Metric
Eun Jeong Gong
J Neurogastroenterol Motil 2021; 27(2): 151-152  https://doi.org/10.5056/jnm21033
Review
Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia
Congzhen Wang and Xiucai Fang
J Neurogastroenterol Motil 2021; 27(2): 153-164  https://doi.org/10.5056/jnm20175
Meta-Analysis
A Systematic Review and Meta-analysis of Randomized Control Trials: Combination Treatment With Proton Pump Inhibitor Plus Prokinetic for Gastroesophageal Reflux Disease
Da Hyun Jung, Cheal Wung Huh, Sang Kil Lee, Jun Chul Park, Sung Kwan Shin, and Yong Chan Lee
J Neurogastroenterol Motil 2021; 27(2): 165-175  https://doi.org/10.5056/jnm20161
Review
Impact of Overlapping Functional Gastrointestinal Disorders on the Quality of Life in Patients With Gastroesophageal Reflux Disease
Shou-Wu Lee and Chi-Sen Chang
J Neurogastroenterol Motil 2021; 27(2): 176-184  https://doi.org/10.5056/jnm19006
Original Articles
Alteration in Integrated Relaxation Pressure During Successive Swallows in Subjects With Normal Manometry Versus Those With Esophagogastric Junction Outflow Obstruction
Abbinaya Elangovan, Fahmi Shibli, and Ronnie Fass
J Neurogastroenterol Motil 2021; 27(2): 185-190  https://doi.org/10.5056/jnm20139
Usefulness of Endoscopic Hill Grade in Evaluating Children Suspected of Having Gastroesophageal Reflux Disease
In Hyuk Yoo, Jung Yeon Joo, and Hye Ran Yang
J Neurogastroenterol Motil 2021; 27(2): 191-197  https://doi.org/10.5056/jnm20033
Simultaneous Evaluation of Laryngopharyngeal Reflux and Swallowing Function Using Hypopharyngeal Multichannel Intraluminal Impedance Measurements in Neurologically Impaired Patients
Daisuke Masui, Suguru Fukahori, Naoki Hashizume, Shinji Ishii, Naruki Higashidate, Saki Sakamoto, Shiori Tsuruhisa, Hirotomo Nakahara, Nobuyuki Saikusa, Yoshiaki Tanaka, and Minoru Yagi
J Neurogastroenterol Motil 2021; 27(2): 198-204  https://doi.org/10.5056/jnm20125
Esophageal Motility Patterns After Peroral Endoscopic Myotomy in Patients With Achalasia
Zuzana Vackova, Jan Mares, Jana Krajciova, Zuzana Rabekova, Lucie Zdrhova, Pavla Loudova, Julius Spicak, Petr Stirand, Tomas Hucl, and Jan Martinek
J Neurogastroenterol Motil 2021; 27(2): 205-214  https://doi.org/10.5056/jnm20126
The Influence of Gastroesophageal Reflux Disease on Daytime Sleepiness and Depressive Symptom in Patients With Obstructive Sleep Apnea
Hyeon Hui Kang, Chul-Hyun Lim, Jung Hwan Oh, Min-Jae Cho, and Sang Haak Lee
J Neurogastroenterol Motil 2021; 27(2): 215-222  https://doi.org/10.5056/jnm20071
Efficacy of S-pantoprazole 10 mg in the Symptom Control of Non-erosive Reflux Disease: A Phase III Placebo-controlled Trial
Yu Kyung Cho, Myung-Gyu Choi, Hyojin Park, Ji Won Kim, Dong Ho Lee, Kwang Hyun Ko, Sang Gyun Kim, Hwoon-Yong Jung, Su Jin Hong, Yong Chan Lee, and Si Hyung Lee
J Neurogastroenterol Motil 2021; 27(2): 223-230  https://doi.org/10.5056/jnm19053
Characteristics of symptomatic belching in patients with belching disorder and patients who exhibit gastroesophageal reflux disease with belching
Shin Ok Jeong, Joon Seong Lee, Tae Hee Lee, Su Jin Hong, Young Sin Cho, Junseok Park, Seong Ran Jeon, Hyun Gun Kim, and Jin-Oh Kim
J Neurogastroenterol Motil 2021; 27(2): 231-239  https://doi.org/10.5056/jnm20114
Impact of serotonin transporter gene polymorphism on gut motility in patients with type 2 Diabetes mellitus
Aastha Malik, Sarama Saha, Rajesh K Morya, Sanjay K Bhadada, and Satya V Rana
J Neurogastroenterol Motil 2021; 27(2): 240-247  https://doi.org/10.5056/jnm20211
A Resting-state Functional Magnetic Resonance Imaging Study of Whole-brain Functional Connectivity of Voxel Levels in Patients With Irritable Bowel Syndrome With Depressive Symptoms
Jie Li, Ping He, Xingqi Lu, Yun Guo, Min Liu, Guoxiong Li, and Jianping Ding
J Neurogastroenterol Motil 2021; 27(2): 248-256  https://doi.org/10.5056/jnm20209
Lactose Sensitivity and Lactose Malabsorption: The 2 Faces of Lactose Intolerance
Michel Bouchoucha, Marinos Fysekidis, Pierre Rompteaux, Jean-Jacques Raynaud, Jean-Marc Sabate, and Robert Benamouzig
J Neurogastroenterol Motil 2021; 27(2): 257-264  https://doi.org/10.5056/jnm20094
High-fat Diet Enhances Gastric Contractility, but Abolishes Nesfatin-1-induced Inhibition of Gastric Emptying
Zarife N Özdemir-Kumral, Türkan Koyuncuoğlu, Sevil Arabacı-Tamer, Özlem T Çilingir-Kaya, Ayça K Köroğlu, Meral Yüksel, and Berrak Ç Yeğen
J Neurogastroenterol Motil 2021; 27(2): 265-278  https://doi.org/10.5056/jnm20206
Colonic Gene Expression and Fecal Microbiota in Diarrhea-predominant Irritable Bowel Syndrome: Increased Toll-like Receptor 4 but Minimal Inflammation and no Response to Mesalazine
Jonna Jalanka, Ching Lam, Andrew Bennett, Anna Hartikainen, Fiona Crispie, Laura A Finnegan, Paul D Cotter, and Robin Spiller
J Neurogastroenterol Motil 2021; 27(2): 279-291  https://doi.org/10.5056/jnm20205
Impaired Colonic Contractility and Intestinal Permeability in Symptomatic Uncomplicated Diverticular Disease
Annamaria Altomare, Manuele Gori, Silvia Cocca, Simone Carotti, Maria Francesconi, Mentore Ribolsi, Sara Emerenziani, Giuseppe Perrone, Sergio Morini, Michele Cicala, and Michele P L Guarino
J Neurogastroenterol Motil 2021; 27(2): 292-301  https://doi.org/10.5056/jnm20110
Letters to the Editor
Transient Receptor Potential Canonical 4 Channel in Interstitial Cells of Cajal as a Target for Control of Gastrointestinal Motility
Zengzi Zhou, Meng Xia, and Jianlin Lv
J Neurogastroenterol Motil 2021; 27(2): 302-304  https://doi.org/10.5056/jnm20267
There Is Something More Important Than Proximal Reflux Episode in the Development of Post-reflux Swallow-induced Peristaltic Wave
Tae Hee Lee
J Neurogastroenterol Motil 2021; 27(2): 305-306  https://doi.org/10.5056/jnm20276

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April 2021
Volume 27
Issue 2
  • News & Notice
  • Tae Hee Lee
    Institute for Digestive Research, Soonchunhyang University Seoul Hospital, Seoul, Korea
    Yu Kyung Cho
    Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary’s hospital, Seoul, Korea
  • Jung Ho Park
    Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  • Kewin T H Siah
    Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore
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