Characteristics and risk factors of Functional Dyspepsia fulfilling the Rome IV Criteria overlapping with Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Constipation in South China

Yan-Qin Long; Wen-Li Xu; Lu-Xiu Li; Hui-Qin He; Jing-Jie Wang; Guo-Dong Shan; Ning Dai; Hong-Tan Chen

doi:10.5056/jnm23084

J Neurogastroenterol Motil https://doi.org/10.5056/jnm23084

Characteristics and risk factors of Functional Dyspepsia fulfilling the Rome IV Criteria overlapping with Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Constipation in South China

Yan-Qin Long

,^1* Wen-Li Xu,¹ Lu-Xiu Li,¹ Hui-Qin He,² Jing-Jie Wang,¹ Guo-Dong Shan,¹ Ning Dai,² and Hong-Tan Chen

^1*

¹Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China; and ²Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China

Correspondence to: Yan-Qin Long, MD
Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, #79 Qingchun Road, Hangzhou 310003, Zhejiang, China
Tel: +86-571-87236730, Fax: +86-571-87236729, E-mail: longyanqin@zju.edu.cn

Hong-Tan Chen, MD
Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, #79 Qingchun Road, Hangzhou 310003, Zhejiang, China
Tel: +86-571-87236730, Fax: +86-571-87236729, E-mail: chenhongtan@zju.edu.cn

*Yan-Qin Long and Hong-Tan Chen are equally responsible for this study.

Received: June 3, 2023; Revised: July 29, 2023; Accepted: September 1, 2023; Published online: September 27, 2023

Abstract: Background/Aims
Functional dyspepsia (FD) overlapping with other gastrointestinal disorders are quite common. The characteristics of FD overlap in Chinese population with latest Rome IV criteria were unclear. This large-scale outpatient-based study assessed the characteristics of FD overlap in South China.
Methods
Consecutive FD patients visited the Gastroenterology Clinic at 2 tertiary medical centers in Hangzhou, China who fulfilled the Rome IV criteria were enrolled. Complete questionnaires related to the gastrointestinal symptoms (Rome IV criteria), Reflux Disease Questionnaire, anxiety and depression, quality of sleep and life, and demographic information were collected.
Results
Among the total of 3281 FD patients, 50.69% overlapped with gastroesophageal reflux disease, 21.46% overlapped with irritable bowel syndrome, 6.03% overlapped with functional constipation. FD overlap had higher proportion of single/divorced/widowed rate, high education level, being employed, drinking, night shift, unhealthy dietary habit than FD only (P < 0.05). They had higher frequency of consultation and economic burden, as well as lower scores in quality of life (P < 0.001). Multivariate logistic regression showed that increasing age, female, low body mass index, history of gastroenteritis, anxiety, depression, and poor sleep quality were independent risk factors for FD overlap.
Conclusions
FD overlap was quite common in China with high economic burden and poor quality of life, FD patients with history of gastroenteritis, anxiety, depression, and poor sleep quality were more likely to have overlap disorders. Awareness of the physical and psychosocial stressors in overlapping condition would help optimize the management of FD overlap in clinical practice.; Keywords: Constipation; Dyspepsia; Gastroesophageal reflux; Irritable bowel syndrome