J Neurogastroenterol Motil  https://doi.org/10.5056/jnm20140
Emergence of Celiac disease and Gluten-related disorders in Asia
Srikant Mohta, Mahendra S Rajput, Vineet Ahuja, and Govind K Makharia*
Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India
Correspondence to: Govind K Makharia, MD, DM, DNB, MNAMS
Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India
Tel: +91-9910678476, E-mail: govindmakharia@gmail.com
Received: June 22, 2020; Revised: August 13, 2020; Accepted: April 22, 2021; Published online: May 6, 2021
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

Celiac disease (CeD) is a systemic, immune-mediated enteropathy, which is triggered by gluten protein in genetically susceptible individuals. CeD, once thought to be an uncommon disease, is now recognized to affect approximately 40-60 million people globally. While CeD is now well reported from a few Asian countries such as India, China, Pakistan, and Middle Eastern countries; it is still believed to be uncommon in the rest of Asia. Gluten-related diseases other than CeD, like non-celiac gluten sensitivity (NCGS) are also emerging globally. CeD and NCGS may present with either intestinal or extra-intestinal symptoms, and a proportion of them have overlapping symptoms with irritable bowel syndrome. Hence, many of them are misdiagnosed as having irritable bowel syndrome in clinical practice. In this review, we discuss the emergence of CeD and other gluten-related disorders, both globally and in Asia, the overlapping manifestations between gluten-related disorders and irritable bowel syndrome, and the challenges associated with diagnosis and management of CeD in Asia.
Keywords: Epidemiology, Glutens, India, Irritable bowel syndrome, Non-celiac gluten sensitivity

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