J Neurogastroenterol Motil 2021; 27(4): 653-654  https://doi.org/10.5056/jnm21059
Impact of Helicobacter pylori-related Microbial Dysbiosis in the Pathogenesis of Metabolic Syndrome and Gastrointestinal Dysmotility Disorders
Jannis Kountouras,1* Apostolis Papaefthymiou,1,2,3 Stergios A Polyzos,3 Elisabeth Vardaka,1,4 Marina Boziki,5 Anthony Kyriakopoulos,6 Fotios Sampsonas,7 George Agrotis,8 Kyriaki Karafyllidou,9 and Michael Doulberis1,3,10
1Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece; 2Department of Gastroenterology, University Hospital of Larisa, Mezourlo, Larisa, Greece; 3First Laboratory of Pharmacology, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece; 4Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Alexander Campus, Thessaloniki, Macedonia, Greece; 5Second Neurological Department, Aristotle University of Thessaloniki, AHEPA University General Hospital of Thessaloniki, Thessaloniki, Macedonia, Greece; 6Department of Research and Development, Nasco AD Biotechnology Laboratory, Piraeus, Greece; 7Department of Respiratory Medicine, University Hospital of Patra, Rion, Patra, Greece; 8Department of Radiology, University Hospital of Larisa, Mezourlo, Larisa, Greece; 9Department of Pediatrics, University Children’s Hospital of Zurich, Zurich, Switzerland; and 10Division of Gastroenterology and Hepatology, Medical University Department, Kantonsspital Aarau, Aarau, Switzerland
Published online: October 30, 2021
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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TO THE EDITOR: Singh et al1 reviewed data on gut dysbiosis and/or interactions involved in the pathogenesis of gastrointestinal tract (GIT) dysmotility and metabolic syndrome (MetS) conditions including irritable bowel syndrome (IBS), functional dyspepsia (FD), and type 2 diabetes mellitus (T2DM). They concluded that MetS is greatly influenced by the gut, thereby metabolic disorders could begin there.

In this respect, Helicobacter pylori infection, a global high burden, induces GIT dysmotility (mainly abnormal gastric emptying).2 Likewise, H. pylori-associated MetS conditions are related with dysmotility-stimulated gastrointestinal microbial overgrowth, potentially leading to bacteremia with systemic conditions.3 As mentioned by the authors,1 MetS occurs commonly in patients with small intestinal bacterial overgrowth (SIBO).3 Gut microbiota has been connected with MetS parameters, and H. pylori-related T2DM, a parameter of MetS, provokes diabetic gastroparesis which may contribute to hepatic encephalopathy (HE) by altering GIT motility and inducing SIBO and subsequent bacterial translocation.4 H. pylori-associated insulin resistance (IR), the main MetS key component,5 may further provoke diabetic gastroparesis, and IR-associated diabetes is linked with bacteremia and sepsis triggering subsequent systemic conditions. In this respect, dysbiosis of the GIT microbiome, including oral and gastric H. pylori bacteria and several non-H. pylori microorganisms, is related with systemic inflammatory processes and conditions, including HE. In the setting of defensins, also mentioned by the authors,1 the upregulation of human β defensin-1 (hBD-1) may present a biomarker of bacterial translocation involved in the pathogenesis of HE.6 Moreover, H. pylori infection appears to induce hBD-1 mRNA expression,6 which also may contribute to the pathophysiology of the central nervous system pathologies, by altering both innate and adaptive immune system reactions.7

Regarding H. pylori and MetS-related FD accompanied by GIT dysbiosis, H. pylori eradication may reduce the risk of MetS criteria in FD patients.8 Likewise, H. pylori and MetS-related IBS may be associated with dysbiosis, and H. pylori eradication therapy may decrease the risk of IBS. Interestingly, H. pylori infection and MetS-related dysbiosis may represent major risk indicators of Parkinson’s disease (PD).5 In this respect, H. pylori infection may affect the bioavailability of L-dopa, a dopamine precursor used for therapy of PD, by injuring the duodenal mucosa, the main place of L-dopa main absorption. On the other hand, H. pylori eradication seems to improve L-dopa onset plus duration time, and PD’s GIT motor fluctuations. Besides, MetS and H. pylori infection are connected with systemic sclerosis (SSc).9 SSc, by inducing GIT dysmotility and SIBO, may trigger the development of complications with high morbidity/mortality. Moreover, SSc is associated with multiple sclerosis, the latter of which is also connected with dysbiosis. Eradication of H. pylori infection may influence the pathophysiology of SSc and multiple sclerosis, at least in certain populations.10 Important to note, however, is that the relationship between H. pylori infection and the aforementioned chronic diseases has not been established yet, and, thus, further large-scale studies are needed.

Financial support

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Conflicts of interest

None.

Author contributions

Jannis Kountouras had the idea and drafted the article; and Apostolis Papaefthymiou, Stergios A Polyzos, Elisabeth Vardaka, Marina Boziki, Anthony Kyriakopoulos, Fotios Sampsonas, George Agrotis, Kyriaki Karafyllidou, and Michael Doulberis have read and agreed with the final manuscript

References
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