J Neurogastroenterol Motil 2016; 22(1): 14-24  https://doi.org/10.5056/jnm15191
Peroral Endoscopic Myotomy for Treating Achalasia and Esophageal Motility Disorders
Young Hoon Youn1, Hitomi Minami2, Philip Wai Yan Chiu3,*, and Hyojin Park1,*
1Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, 2Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan, 3Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong
Correspondence to: Philip Wai Yan Chiu, MD, FRCSEd, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, Tel: +852-2632-2627, Fax: +852-2632-7974, E-mail: philipchiu@surgery.cuhk.edu.hk. Hyojin Park, MD, PhD, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University Medical College, 211 Eonjuro, Gangnam-gu, Seoul 06273, Korea, Tel: +82-2-2019-3318, Fax: +82-2-3463-3882, E-mail: hjpark21@yuhs.ac
Received: December 1, 2015; Revised: December 14, 2015; Accepted: December 22, 2015; Published online: January 30, 2016
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Peroral endoscopic myotomy (POEM) is the application of esophageal myotomy to the concept of natural orifice transluminal surgery (NOTES) by utilizing a submucosal tunneling method. Since the first case of POEM was performed for treating achalasia in Japan in 2008, this procedure is being more widely used by many skillful endosopists all over the world. Currently, POEM is a spotlighted, emerging treatment option for achalasia, and the indications for POEM are expanding to include long-standing, sigmoid shaped esophagus in achalasia, even previously failed endoscopic treatment or surgical myotomy, and other spastic esophageal motility disorders. Accumulating data about POEM demonstrate excellent short-term outcomes with minimal risk of major adverse events, and some existing long-term data show the efficacy of POEM to be long lasting. In this review article, we review the technical details and clinical outcomes of POEM, and discuss some considerations of POEM in special situations.

Keywords: Achalasia, Myotomy, Peroral endoscopic myotomy, Treatment

Achalasia and the History of Peroral Endoscopic Myotomy

Surgical myotomy has been the most reliable treatment of choice for treating esophageal achalasia since the first report by Heller in 1913.1 Other management methods include medication, balloon dilatation,2,3 and botulinum toxin injection,4,5 which are still inconclusive because of the relatively low efficacy and also relatively high complication rates.

The concept of natural orifice transluminal endoscopic surgery (NOTES) was introduced by Kalloo and his colleagues.6,7 Under the influence of the rapidly increasing demands for less-invasive treatment, Inoue et al8 introduced peroral endoscopic myotomy (POEM) in humans as a non-surgical treatment method for esophageal achalasia in 2010. Since then, POEM has been one of the standard treatments for treating esophageal achalasia and related esophageal motility diseases, such as diffuse esophageal spasm and jackhammer esophagus.8?10

Table 1 summarizes the general characteristics of POEM compared with laparoscopic Heller myotomy and pneumatic dilation.

Procedure of Peroral Endoscopic Myotomy


The indications for POEM encompass the conditions that are responsible for the excessive behavior of the inner circular muscle layer. Unlike other options, POEM theoretically allows myotomy to be performed for muscles of any length, position, and direction because of its intraluminal route of approach. Therefore, esophageal achalasia is the most cardinal indication. Furthermore, diffuse esophageal spasm (distal esophageal spasm, DES), jackhammer esophagus, and surgically failed cases, all of which require flexible myotomy depending on the condition in each case, can also be recommended indications.11 Moreover, POEM may be the only option for surgically failed cases because surgical re-do myotomy is extremely difficult due to the fibrosis and scarring as a result of previous surgery.

Pre-operative Evaluation

Esophagogastroduodenoscopy (EGD), barium swallow, and manometry should be performed preoperatively in order to confirm the diagnosis and the treatment strategy. Evaluation of the shape of the esophagus, disease progression grade, and dynamic observation of the esophagus is mandatory to comprehend the pathology of the disease.

EGD enables us to assess the width of the esophagus, the amount of the esophageal contents, and abnormal movement of the esophageal body. EGD is also requisite to rule out pseudoachalasia; computed tomography or endoscopic ultrasound is also required to rule out submucosal cancer in the esophagus/gastric cardia, or extrinsic compression due to lymph node swelling or tumors of the adjacent structures.12 Because achalasia is a high-risk factor of esophageal cancer, direct visualization of the mucosal surface is quite important in order to detect the early signs of esophageal cancer.

According to the shape of the esophagus, achalasia patients are classified as having the straight or sigmoid type with severe tortuosity. The maximum diameter of the thoracic esophagus is also measured. Barium esophagogram allows us to visualize important information about the dynamics of the esophagus, such as the site of abnormal contraction, simultaneous contraction, and barium accumulation. Timed barium esophagogram (TBE) measures the distance from the distal esophagus to the top of a distinct retained barium column (barium height) and the maximal esophageal width (barium width) at 1, 2, and 5 minutes after barium ingestion. TBE is a noninvasive and effective method in both the diagnosis and evaluation of response to treatment of achalasia.

Esophageal manometry is another essential examination suitable for the evaluation of detailed esophageal function. The Chicago classification of esophageal motility was developed by Bredenoord et al13 who interpreted the results of clinical high-resolution manometry (HRM) studies. The latest version of the classification was released in 2015, considering the updating technology and clinical practice.14


Patients are admitted on the day before POEM and were asked to fast (no solid food) for 24 hours before the procedure. EGD is performed before the administration of general anesthesia in order to remove the food remnants from the esophagus prior to intubation. Patients are asked to lie in the supine position. Administration of broad-spectrum intravenous antibiotics is started before POEM for prevention of infection.

A forward-viewing endoscope is used with a transparent distal cap attachment (DH-28GR, FTS). A triangle tip knife (KD-640L; Olympus) or possibly other endoscopic knives can be used to dissect the submucosal layer and to divide circular muscle bundles. A coagulating forceps (Coagrasper, FD-411QR; Olympus) is used for vessel coagulation of larger vessels prior to dissection and for hemostasis. An electrogenerator, VIO 300D (ERBE, Tubingen, Germany) is utilized. In addition, hemostatic clips (EZ-CLIP, HX-110QR; Olympus) are applied for the final closure of the mucosal entry site. The procedures are performed with the patient under general anesthesia with positive pressure ventilation. The UCR CO2 insufflator (Olympus) is used with a regular insufflating tube (MAJ-1742; Olympus), which maintains continuous CO2 insufflation at a constant rate of 1.2 liter/minute.

Precise Operative Steps

The POEM procedure is performed as follows:

  • Approximately 10 mL saline supplemented with 0.3 % indigo carmine is injected into the submucosal space on the anterior (11?2 o’clock) or posterior (5 o’clock) wall of the mid-esophagus. Subsequently, a 2-cm longitudinal mucosal incision is made as a mucosal entry into the submucosal space (the dry cut mode [50 W, effect 3], or the Endocut I mode) (Fig. 1). Then, a technique similar to endoscopic submucosal dissection is used to create a submucosal tunnel approximately 2 or 3 cm into the proximal stomach (Fig. 2). The spray coagulation mode (40?60 W, effect 1?2) is used to dissect the submucosal layer. Larger vessels in the submucosa are coagulated using the forceps in the soft coagulation mode (80 W, effect 5). The determination of anterior (11?2 o’clock) or posterior (5 o’clock) position of submucosal tunneling and myotomy is up to the preference of the operator. Although there is few evidence, many experts suggest that posterior myotomy may have an advantage for relief of dysphagia, and anterior myotomy may be better in the prevention of gastroesophageal reflux disease.

  • Dissection of the circular muscle bundle is started at 2?3 cm distal from the mucosal entry by using a triangle tip knife (Fig. 3). The captured circular muscle is cut by using a spray coagulation current (40?60 W, effect 1?2), avoiding massive bleeding from the intra-muscular vessels. Division of the sphincter muscle is continued from the proximal side towards the stomach and 2 or 3 cm into the cardia (Fig. 3), according to the surgical standards of Heller myotomy. The esophagogastric junction (EGJ) is identified by recognizing one or more of the following: (1) the narrow segment of the esophageal lumen at the lower esophageal sphincter (LES) and opening in the stomach, (2) change of the vascular pattern and palisade vessels that were identified when dissecting the tunnel, as well as irregularly arranged vessels in the gastric cardia, (3) tattooing with indocyanine green by recognizing the color of indocyanine green injected prior to myotomy,15 and (4) double scope technique in which a second endoscope is used to obtain a retroflexed view of the gastric cardia, while the dissecting scope transilluminate from the end of the submucosal tunnel.16

  • After completion of the myotomy, improvement of the endoscope passage at the EGJ is confirmed from inside the tunnel and the true esophageal lumen. The incised mucosal entry is closed with hemostatic clips after prophylactic antibiotic solution spraying inside the tunnel. Complete closure of the mucosal entry is confirmed endoscopically (Fig. 4).

Postoperative Care

Oral intake of clear water is started after the esophagogram or EGD confirms the smooth passage of a contrast agent without leakage and absence of ischemic/hemorrhagic color change of the mucosa. On post-operative day 2, a soft diet is started. The use of intravenous antibiotics is discontinued 3 days after the procedure; antibiotics were switched to oral intake for another 7 days.

The functional evaluations including TBE, manometry and pH-metry as well as endoscopy are repeated 3?6 months after POEM in order to elucidate the effect of the procedure, complications, and changes to esophageal motility.17

Outcomes of Peroral Endoscopic Myotomy

Short-term Outcomes

Because POEM is a treatment option for symptomatic achalasia or esophageal motility disorders, the most important measure in evaluating the clinical efficacy of POEM should be subjective symptoms. Most clinical series of POEM report pre- and post-POEM Eckhart’s score as a subjective measure of treatment efficacy, and mostly define clinical success as a post-POEM Eckhart’s score of < 3. The short-term clinical success of POEM was reported to be 82% to 100% until 12 months, mostly > 90%, which is highly effective. Some studies also investigated the quality of life before and after POEM by using a standardized questionnaire, and showed that POEM provided significant improvement in the quality of life.24?27

For objective measurements of efficacy, various parameters can be compared before and after the treatment of achalasia. The objective parameters include barium column height in timed barium esophagograms (TBE),28,29 LES pressure, integrated relaxation pressure,30 and GE junction distensibility as measured by EndoFLIP (Endolumenal Functional Lumen Imaging Probe; Crospon, Galway, Ireland).31 Many studies regarding POEM reported not only subjective clinical symptomatic success, but also objective assessment. POEM has also demonstrated a significant reduction of TBE column height, LES pressure, and integrated relaxation pressure in most cases.19,26,32 EndoFLIP provides a quantitative assessment of luminal patency and sphincter distension, and recently has been increasingly reported as a method of assessing the adequacy of myotomy. EGJ distensibility measurements on EndoFLIP have been shown to correlate better with postoperative symptoms compared to manometric pressure measurements.33 Intraprocedural application of EndoFLIP to POEM was highly predictive of postoperative symptomatic outcomes.34,35

Along with the improvement of manometric profiles of EGJ, some patients also experienced recovery of esophageal body peristalsis after treatment of achalasia. There have been a few reports of recovery of esophageal body peristalsis after POEM for achalasia. Forty-seven percent of patients had partial recovery of peristalsis in an early European multicenter series of POEM,19 and 36% of achalasia patients in another single-center study showed some return of normal peristalsis (≥ 70% peristalsis) on post-operative HRM.36 However, esophageal body peristalsis does not seem to be consistently affected. Another recently published study demonstrated that only 2 of 66 patients had some degree of antegrade peristalsis after POEM.37 Further study is needed to clarify the recovery of esophageal body peristalsis after POEM.

Long-term Outcomes

Long-term follow-up data after POEM are accumulating over time. A representative long-term follow-up study is the one performed by Inoue et al,38 who reported the outcomes of 500 consecutive patients treated with POEM with a follow-up of more than 3 years. They showed that 2-month, 1- to 2-year, and 3-year overall success rates were 91.3%, 91.0%, and 88.5%, respectively.38Table 2 summarizes the findings of seven recently published studies that report the long-term outcomes of POEM after a follow-up of more than 1 year.19,36,38?42 Most of these series demonstrated a sustained clinical success of POEM in > 90% of patients, with the follow-up duration ranging from 12 months to > 36 months.19,36,38?42 However, one international prospective multicenter study showed some decline in clinical success over time.39 Von Renteln et al39 demonstrated a 97% treatment success at 3 months, 88.5% at 6 months, and 82.4% at 12 months, which significantly declined from the initial treatment success. Although we cannot determine the exact reason of such a decline in the efficacy in this trial, one can suppose that it is probably due to the multicenter nature of this trial conducted in the relatively early stage of the POEM era, because of the variability in experience and performance of the operators.

To summarize, the literature to date supports the notion that the high efficacy of POEM generally seems to be durable and long lasting.

Complications of Peroral Endoscopic Myotomy

As reported, the POEM procedure can be described as a surgical myotomy that is done in an endoscopic manner. Therefore, minor pneumomediastinum or pneumoperitoneum with minimum effects on perioperative course are not considered complications.

So far, there have been considerably many studies regarding POEM against esophageal achalasia, with more than 1000 cases after introduction of the technique. Zhong and his colleagues collected data about complications from their 119 cases in 2012.43 Complications related to gas insufflation such as cutaneous emphysema, pneumothorax, and pneumoperitoneum occurred in more than half of all the patients (subcutaneous emphysema [55.5%, 66/119], pneumothorax [2.5%, 3/119], and pneumoperitoneum [39.5%, 47/119]). The use of CO2 as an insufflating gas and general anesthesia with positive ventilation is necessary to avoid these complications. They mentioned that the incidence of these complications significantly reduced after they started to use CO2 as an insufflating gas.

They also reported that delayed hemorrhage occurred in 1 patient. The patient recovered after conservative management after the blood clot was removed from the submucosal tunnel lumen by gastroscopy. Severe mediastinitis is another important post-operative complication. There have been also some reports of mediastinal leakage due to esophageal perforation, which needed thoracoscopic or laparoscopic drainage and extended hospital stay.20,27,44 Complete and precise closure of the entry site and careful observation after starting solid foods are important to avoid this unfavorable complication.

In a recent literature published by Inoue and his colleagues, the incidence of adverse events related to the POEM procedure was < 3.2%, including 1 case of pneumothorax, 1 case of severe bleeding, 3 cases of post-operative hematomas, and 1 case of local peritonitis. All patients with these complications recovered with conservative treatment, and no procedure-related deaths were reported.38

Peroral Endoscopic Myotomy in Special Situations

Pediatric Patients

One of the concerns regarding POEM would be the feasibility of this procedure in extremely young patients. However, there have been several case reports of successful POEM even in infants, resulting in a good clinical response without specific complications.45,46 In a recent relatively large series of POEM in 27 children with achalasia, the authors reported that a total of 26 patients (96.3%) underwent successful POEM. Submucosal tunneling failed in 1 patient because of serious inflammation and adhesion. Among the 26 children who received successful POEM, the clinical treatment success was maintained in all during a mean follow-up period of 24.6 months (range 15?38 months), and no serious adverse events related to POEM were encountered.41 These data suggest that the efficacy and safety of POEM in pediatric achalasia patients are also promising, similar to those in adult patients.

Previous Endoscopic and Surgical Treatment

There can be some concerns about the feasibility, safety, and efficacy of POEM in patients who have undergone previous endoscopic (botulinum toxin injections or pneumatic balloon dilation) or surgical treatment. Previous intervention at the EGJ may result in some degree of submucosal fibrosis that hinders safe submucosal tunneling through the EGJ. Previous interventions may possibly make the POEM procedure more difficult compared to that in treatment na?ve patients.

Regarding previous endoscopic treatment, a study prospectively compared the POEM procedure in 30 na?ve patients, with 21 patients who had undergone previous pneumatic dilation.47 This study showed a significantly longer operation time in the patients with previous pneumatic dilations; however, the outcomes in terms of the efficacy and safety were similar in both groups.47 Another study about the learning curve of POEM also showed that previous endoscopic treatment was one of the independent predictive factors of a longer procedure time.48 However, there were also several contrary results that showed no significant difference even in operation time, efficacy, and safety.49?51

POEM could also be used in the setting of recurrence or failure after previous surgical myotomy. The results of three studies examining the utility of POEM in patients who have undergone a previous surgical myotomy have been published. Zhou et al52 reported 12 patients, Onimaru et al11 reported 10 patients, and Vigneswaran et al53 reported 5 patients, whose symptoms recurred after Heller myotomy; these patients subsequently underwent salvage POEM. All these series showed acceptable feasibility, safety, and relatively high clinical efficacy in the range of 91.7% to 100%.11,52,53

In conclusion, POEM in the setting of previous interventions seems to be equally safe and efficacious when performed by experts; however, it may be more technically challenging. Therefore, inexperienced POEM operators must be cautious while treating such cases.

Sigmoid-shaped Esophagus in Achalasia

Some advanced achalasia patients show progression to a sigmoid esophagus due to severe dilatation and subsequent tortuous angulation of their esophageal lumen. Severe sigmoid esophagus can markedly increase the procedural difficulty of POEM. Patients with severe esophageal stasis could show inflammation and fibrosis of the submucosa, hindering submucosal tunneling; severe angulations also make the direction of submucosal tunneling very puzzling.17 In our experience, the deepest possible submucosal tunneling could help maintain the correct aboral direction of the submucosal tunnel by ensuring the direction to be perpendicular to the circular muscle fibers. Although some experts reported good feasibility and efficacy of POEM even in these advanced patients,8,40 these cases seem to be particularly challenging and should be performed only by highly experienced operators.

Spastic Esophageal Disorders

Spastic esophageal disorders (SEDs) may include spastic achalasia (type III achalasia), distal esophageal spasm (diffuse esophageal spasm [DES]), and jackhammer esophagus.14 Although each of these disorders has a different pathophysiology, they share many similar clinical symptoms such as chest pain, regurgitation, and dysphagia. In terms of the coexistence of dysphagia and esophageal spasm, surgical myotomy is one of the best treatment options for SEDs.54 Similarly, POEM could also be applied for the treatment of these SEDs, and there have been multiple case reports that showed that POEM had excellent clinical efficacy for various SEDs, including jackhammer esophagus, DES, or Nutcracker esophagus.9,10,55?59 The results of an international multicenter study of POEM for SEDs were recently published.60 This study collected retrospective data of 9 patients with DES, 10 patients with jackhammer esophagus, and 54 patients with spastic achalasia from 11 centers. Overall, a clinical response was observed in 93%, and the clinical response in each disease category was 100% in DES, 96.3% in spastic achalasia and 70% in jackhammer esophagus, which was significantly lower than that of other diseases. The jackhammer esophagus possibly may be a more difficult entity to treat with POEM when compared to both spastic achalasia and DES. The authors suggested the reason for the diminished response of POEM in jackhammer esophagus seems to be related to the extremely high contractility of the esophageal body; they suggested the value of concomitant bilateral (anterior and posterior) myotomy as a possible alternative for such patients. However, we think that the length of myotomy is still the most important factor for clinical success in jackhammer esophagus. POEM for SEDs generally involved long myotomy (mean length = 16 cm),60 which was almost double of that used in conventional POEM, because patients with these SEDs frequently have chest pain often associated with spastic contraction of the esophageal body.61 When the patient has chest pain (common in DES, jackhammer esophagus, and nutcracker esophagus), which may be related to abnormal spastic contractions, the POEM operator should take care to ensure the length of the myotomy extends to the area of the most proximal spastic contraction. However, in some cases with long spastic contraction of the esophageal body, such a long myotomy length might still be insufficient, and the remnant proximal spastic segment may affect residual symptoms. In a previous case report, a woman with jackhammer esophagus was treated with POEM but presented with symptomatic recurrence after six months. The high resolution manometry showed a remnant spasm segment of the esophageal body proximal to the myotomy, and her symptoms could be resolved after endoscopic balloon dilation of the proximal spastic segment.55

The myotomy length should be decided on the basis of the patients’ manometric, radiological, clinical, and endoscopic findings, especially in patients with SEDs. Although the accumulated data are not enough, POEM seems to be a very promising treatment option for patients with these SEDs.

Future Perspective of Peroral Endoscopic Myotomy

There have been numerous studies regarding the efficacy and application of POEM. It can be used to treat a variety of esophageal motility disorders including all types of achalasia, DES, and jackhammer esophagus. However, there is still ongoing discussion about the role of POEM in the management algorithm of achalasia, and where it stands in relation to balloon dilatation and surgical myotomy.

Further questions have arisen as POEM is being accepted widely. The questions include the ideal length of myotomy, the side to be cut, and if a full layer endoscopic myotomy or just division of the inner circular muscle should be performed. Further evaluation with longer observation is needed to evaluate these issues.

POEM has also brought tremendous attention to esophageal motility diseases, which includes the etiology of achalasia,62 carcinogenesis of the disease,63 and endoscopic diagnosis.64,65 The whole story regarding esophageal achalasia may be elucidated in the near future.

Fig. 1. Entry to the submucosal space. After submucosal injection of saline and 0.3% indigo carmine mixture, a 2-cm longitudinal mucosal incision is made at the mid esophagus.

Fig. 2. Submucosal tunneling. A long submucosal tunnel is created 2?3 cm distal to the esophagogastric junction. The circular muscle fibers are perpendicular to the longitudinal direction of the tunnel.

Fig. 3. Endoscopic myotomy of circular muscle bundle begins from 2?3 cm distal to the mucosal entry and extends to 2?3 cm distal to the esophagogastric junction. By using a triangle tip knife, endoscopic myotomy of inner circular muscle bundles is done, leaving the outer longitudinal muscle layer intact.

Fig. 4. Closure of the mucosal entry. The mucosal incision of entry point is completely closed with hemostatic clips.


Characteristics of Peroral Endoscopic Myotomy Compared with Laparoscopic Heller Myotomy and Pneumatic Dilation

Selective circular myotomyPossibleNoNo
Concurrent anti-reflux procedureNoFundoplicationNo
Dissection and disruption of the diaphragmatic hiatusNoYesNo
Postoperative incidence of GERD(+++)
Symptomatic GERD approximately 20?30%
Symptomatic GERD approximately 15%
Myotomy extension to the proximal esophageal bodyPossibleDifficultImpossible
Hospital stayIntermediateRelatively longVery short
CostIntermediate (variable according to region)HighLow
Clinical response for achalasiaGood (excellent)GoodFair
Clinical response for spastic esophageal disordersGoodFairPoor

POEM, peroral endoscopic myotomy; LHM, laparoscopic Heller myotomy; PD, pneumatic dilation; GERD, gastroesophageal reflux disease.

Long-term Efficacy of Peroral Endoscopic Myotomy (Data from Published Studies in the Order of a Long Follow-up Duration)

Total subject numberFollow-up (months)Clinical successEckardt score (before/after)LES pressure (mmHg) (before/after)Clinical GERD (symptomatic or PPI use)
Inoue et al38500Over 3688.5% (54/61)6.0/1.728.7/14.021.3%
Hu et al4032 (Sigmoid type)30 (median)96.8%7.8/1.437.9/12.925.8%
Chen et al4126 (pediatric patients)24.6 (mean)100%8.3/0.731.6/12.919.2%
Sharata et al367520.1 (mean)97%6/122.2/11.719.1%
Minami et al422816 (median)100%6.7/0.771.2/2121.4%
Teitelbaum et al194115 months (median)92%7/128/1115%
Von Renteln et al397012 (median)82.4%6.9/127.6/8.929%

LES, lower esophageal sphincter; GERD, gastroesophageal reflux disease; PPI, proton pump inhibitor.

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