Fig. 1. Chloride channel activation in the treatment of constipation. Reprinted from Menees et al with permission from Macmillan Publishers Ltd. ClC-2, type-2 chloride channel; CFTR, cystic fibrosis transmembrane regulator; GC-C, guanylate cyclase-C; GTP, guanosine triphosphate; cGMP, cyclic guanosine monophosphate.

J Neurogastroenterol Motil 2014;20:141~151 https://doi.org/10.5056/jnm.2014.20.2.141

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