Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 5. Comparison of % inhibition, % omeprazole (OMP) binding and % plasma level. Radioactive OMP was orally administrated at a dosage of 10 mg/kg, and the drug concentration in the plasma level and the inhibition of acid secretion in the pylorus-ligated rats were measured. Then, the pump enzyme was isolated from each stomach. Radioactive OMP bound to the enzyme was measured together with quantity of the enzyme. Maximum binding stoichiometry was 2.5 nmol/mg of the enzyme. Error bar is SD (n = 5). % inhibition, % inhibition of gastric acid secretion.
Journal of Neurogastroenterology and Motility 2013;19:25~35
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