Comparison of Symptom Profiles Before and 3 Months After Anti-reflux Mucosal Ablation
| Questionnaire | Pre-ARMA | Post-ARMA | P-value |
|---|---|---|---|
| GerdQ | |||
| 1. Heartburn | 1.84 ± 1.46 | 1.00 ± 1.15 | 0.061 |
| 2. Regurgitation | 2.21 ± 1.23 | 1.63 ± 1.26 | 0.157 |
| 3. Epigastralgia | 2.32 ± 1.25 | 2.74 ± 0.81 | 0.163 |
| 4. Nausea | 2.84 ± 0.69 | 2.84 ± 0.69 | 1.000 |
| 5. Sleep disturbance | 1.95 ± 1.31 | 0.84 ± 1.26 | 0.015 |
| 6. OTC medications | 0.00 ± 0.00 | 0.05 ± 0.23 | 0.331 |
| Total scores | 11.16 ± 2.67 | 9.11 ± 2.64 | 0.026 |
| RSI | |||
| 1. Hoarseness | 2.16 ± 1.61 | 0.58 ± 0.96 | < 0.001 |
| 2. Clearing throat | 1.74 ± 1.63 | 0.95 ± 1.27 | 0.035 |
| 3. Excess throat mucus or postnasal drip | 1.11 ± 1.41 | 0.79 ± 1.18 | 0.331 |
| 4. Difficulty swallowing food, liquid, or pills | 0.63 ± 0.96 | 0.26 ± 0.65 | 0.202 |
| 5. Cough after eating or lying | 0.63 ± 0.96 | 0.16 ± 0.50 | 0.046 |
| 6. Breathing difficulties or choking | 0.74 ± 0.99 | 0.16 ± 0.50 | 0.053 |
| 7. Troublesome or annoying cough | 0.00 ± 0.00 | 0.16 ± 0.50 | 0.187 |
| 8. Lump in throat | 1.42 ± 1.46 | 0.89 ± 1.10 | 0.228 |
| 9. Heartburn, chest pain, indigestion, or stomach acid coming up | 3.21 ± 1.27 | 2.16 ± 1.12 | 0.012 |
| Total scores | 11.63 ± 5.62 | 6.11 ± 3.86 | 0.001 |
| PAGI-SYM | |||
| 1. Heartburn during the day | 1.84 ± 1.71 | 1.05 ± 1.35 | 0.144 |
| 2. Regurgitation during the day | 1.89 ± 1.63 | 1.16 ± 1.34 | 0.172 |
| 3. Nausea | 0.74 ± 1.24 | 0.58 ± 1.22 | 0.506 |
| 4. Upper abdominal pain | 0.78 ± 1.35 | 0.50 ± 0.86 | 0.482 |
| 5. Stomach fullness | 1.16 ± 1.46 | 0.47 ± 1.02 | 0.019 |
| 6. Loss of appetite | 0.58 ± 1.12 | 0.37 ± 0.76 | 0.360 |
| 7. Upper abdominal discomfort | 2.21 ± 1.40 | 1.16 ± 1.30 | 0.012 |
| 8. Bloating | 2.11 ± 1.52 | 1.11 ± 1.33 | 0.006 |
| 9. Heartburn when lying down | 2.05 ± 1.87 | 0.68 ± 1.42 | 0.019 |
| 10. Regurgitation when lying down | 2.63 ± 1.89 | 1.63 ± 1.61 | 0.062 |
| 11. Lower abdominal pain | 0.21 ± 0.63 | 0.05 ± 0.23 | 0.331 |
| 12. Feeling chest discomfort during the day | 2.11 ± 1.59 | 0.89 ± 1.29 | 0.028 |
| 13. Bitter, acid, or sour taste in the mouth | 2.21 ± 1.44 | 0.79 ± 1.13 | 0.002 |
| 14. Lower abdominal discomfort | 0.21 ± 0.63 | 0.05 ± 0.23 | 0.331 |
| 15. Feeling chest discomfort at night | 2.05 ± 1.72 | 0.47 ± 1.17 | 0.007 |
| 16. Retching | 0.16 ± 0.69 | 0.21 ± 0.92 | 0.331 |
| 17. Belly visibly larger | 1.16 ± 1.34 | 0.53 ± 0.96 | 0.048 |
| 18. Vomiting | 0.42 ± 1.02 | 0.37 ± 1.12 | 0.841 |
| 19. Unable to finish a normal-sized meal | 0.63 ± 1.16 | 0.53 ± 0.96 | 0.682 |
| 20. Feeling excessively full after meals | 1.84 ± 1.57 | 0.68 ± 1.11 | 0.002 |
ARMA, anti-reflux mucosal ablation; OTC, over-the-counter; RSI, reflux severity index; PAGI-SYM, patient assessment of upper gastrointestinal symptom severity index.
Data are presented as mean ± SD.