Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Correlation Coefficients Between Baseline Impedance Measured During High-resolution Impedance Manometry, Mean Nocturnal Baseline Impedance, and Percent of Acid Exposure Time

HRIM-BI and AET All patients (n = 74) CTRSa (n = 28) ILPRSb (n = 46)
MNBI Distal esophageal acid exposure (%) MNBI Distal esophageal acid exposure (%) MNBI Distal esophageal acid exposure (%)
Proximal esophagus Distal esophagus
(5 cm)
Distal esophagus
(3 cm)
Proximal esophagus Distal esophagus
(5 cm)
Distal esophagus
(3 cm)
Proximal esophagus Distal esophagus
(5 cm)
Distal esophagus
(3 cm)
HRIM-BI
cm below the UES
2 ± 1 cm 0.04 –0.08 0.02 0.01 –0.21 –0.04 –0.02 0.05 0.14 –0.09 0.03 –0.02
4 ± 1 cm 0.06 –0.06 0.07 0.02 –0.30 0.002 –0.01 0.20 0.22 –0.11 0.10 –0.07
6 ± 1 cm –0.02 –0.03 0.08 0.06 –0.32 –0.04 –0.05 0.18 0.10 –0.06 0.10 0.02
Proximal average 0.05 –0.06 0.06 0.04 –0.29 –0.03 –0.04 0.13 0.18 –0.09 0.07 0.01
cm above the LES
8 ± 1 cm 0.10 0.21 0.34d –0.12 –0.04 0.03 0.13 –0.12 0.18 0.31c 0.43d –0.13
6 ± 1 cm 0.16 0.27c 0.35d –0.10 –0.03 0.09 0.18 –0.11 0.25 0.38d 0.44d –0.12
4 ± 1 cm 0.11 0.23 0.34d –0.07 –0.06 0.02 0.15 –0.05 0.23 0.35c 0.44d –0.13
2 ± 1 cm 0.09 0.23 0.38d –0.18 0.007 0.05 0.26 –0.18 0.15 0.31c 0.44d –0.23
Distal average 0.13 0.26c 0.39d –0.14 –0.04 0.05 0.18 –0.09 0.24 0.37d 0.48d –0.18
24-hr pH test
AET –0.22 –0.49e –0.56e - –0.29 –0.63e –0.74e - –0.20 –0.39d –0.46d -

aConcomitant typical reflux syndrome (CTRS) is defined as regurgitation or heartburn at least twice a week with mild symptoms, or once a week with moderate/severe symptoms.

bIsolated laryngopharyngeal reflux symptoms (ILPRS) is defined as patients with laryngopharyngeal reflux without CTRS.

cP < 0.05, dP < 0.01, eP < 0.001 for Spearman correlations.

HRIM-BI, baseline impedance measured during high-resolution impedance manometry; AET, % of acid exposure time in the distal esophagus; MNBI, mean nocturnal baseline impedance; UES, upper esophageal sphincter; LES, lower esophageal sphincter.

J Neurogastroenterol Motil 2025;31:63~74 https://doi.org/10.5056/jnm24051
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