
Correlation Coefficients Between Baseline Impedance Measured During High-resolution Impedance Manometry, Mean Nocturnal Baseline Impedance, and Percent of Acid Exposure Time
HRIM-BI and AET | All patients (n = 74) | CTRS |
ILPRS |
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MNBI | Distal esophageal acid exposure (%) | MNBI | Distal esophageal acid exposure (%) | MNBI | Distal esophageal acid exposure (%) | |||||||||
Proximal esophagus | Distal esophagus (5 cm) |
Distal esophagus (3 cm) |
Proximal esophagus | Distal esophagus (5 cm) |
Distal esophagus (3 cm) |
Proximal esophagus | Distal esophagus (5 cm) |
Distal esophagus (3 cm) |
||||||
HRIM-BI | ||||||||||||||
cm below the UES | ||||||||||||||
2 ± 1 cm | 0.04 | –0.08 | 0.02 | 0.01 | –0.21 | –0.04 | –0.02 | 0.05 | 0.14 | –0.09 | 0.03 | –0.02 | ||
4 ± 1 cm | 0.06 | –0.06 | 0.07 | 0.02 | –0.30 | 0.002 | –0.01 | 0.20 | 0.22 | –0.11 | 0.10 | –0.07 | ||
6 ± 1 cm | –0.02 | –0.03 | 0.08 | 0.06 | –0.32 | –0.04 | –0.05 | 0.18 | 0.10 | –0.06 | 0.10 | 0.02 | ||
Proximal average | 0.05 | –0.06 | 0.06 | 0.04 | –0.29 | –0.03 | –0.04 | 0.13 | 0.18 | –0.09 | 0.07 | 0.01 | ||
cm above the LES | ||||||||||||||
8 ± 1 cm | 0.10 | 0.21 | 0.34 |
–0.12 | –0.04 | 0.03 | 0.13 | –0.12 | 0.18 | 0.31 |
0.43 |
–0.13 | ||
6 ± 1 cm | 0.16 | 0.27 |
0.35 |
–0.10 | –0.03 | 0.09 | 0.18 | –0.11 | 0.25 | 0.38 |
0.44 |
–0.12 | ||
4 ± 1 cm | 0.11 | 0.23 | 0.34 |
–0.07 | –0.06 | 0.02 | 0.15 | –0.05 | 0.23 | 0.35 |
0.44 |
–0.13 | ||
2 ± 1 cm | 0.09 | 0.23 | 0.38 |
–0.18 | 0.007 | 0.05 | 0.26 | –0.18 | 0.15 | 0.31 |
0.44 |
–0.23 | ||
Distal average | 0.13 | 0.26 |
0.39 |
–0.14 | –0.04 | 0.05 | 0.18 | –0.09 | 0.24 | 0.37 |
0.48 |
–0.18 | ||
24-hr pH test | ||||||||||||||
AET | –0.22 | –0.49 |
–0.56 |
- | –0.29 | –0.63 |
–0.74 |
- | –0.20 | –0.39 |
–0.46 |
- |
aConcomitant typical reflux syndrome (CTRS) is defined as regurgitation or heartburn at least twice a week with mild symptoms, or once a week with moderate/severe symptoms.
bIsolated laryngopharyngeal reflux symptoms (ILPRS) is defined as patients with laryngopharyngeal reflux without CTRS.
cP < 0.05, dP < 0.01, eP < 0.001 for Spearman correlations.
HRIM-BI, baseline impedance measured during high-resolution impedance manometry; AET, % of acid exposure time in the distal esophagus; MNBI, mean nocturnal baseline impedance; UES, upper esophageal sphincter; LES, lower esophageal sphincter.