Diagnostic Accuracy of Baseline Impedance Measured During High-resolution Impedance Manometry for Pathological Mean Nocturnal Baseline Impedance
| Comparison of HRIM-BI between MNBI (+) and control groups | AUC | Cut-point | Sensitivity | Specificity | Relative risk (95% CI) | P-value |
|---|---|---|---|---|---|---|
| Patients MNBI(+) vs MNBI(–) | ||||||
| CTRS |
0.70 | 1095 | 0.75 | 0.62 | 4.9 (1.8-13.4) | 0.004 |
| CTRS |
0.57 | 1143 | 0.79 | 0.43 | 2.8 (0.5-14.4) | 0.400 |
| ILPRS |
0.78 | 1066 | 0.83 | 0.68 | 10.6 (2.4-46.0) | < 0.001 |
| Patients MNBI(+) vs healthy controls | ||||||
| CTRS |
0.71 | 886 | 0.63 | 0.74 | 4.7 (1.5-15.3) | 0.020 |
| CTRS |
0.65 | 1180 | 0.79 | 0.52 | 4.0 (0.9-18.2) | 0.090 |
| ILPRS |
0.76 | 886 | 0.72 | 0.74 | 7.4 (1.8-30.0) | 0.009 |
aConcomitant typical reflux syndrome (CTRS) is defined as regurgitation or heartburn at least twice a week with mild symptoms, or once a week with moderate/severe symptoms.
bIsolated laryngopharyngeal reflux symptoms (ILPRS) is defined as patients with laryngopharyngeal reflux without CTRS.
HRIM-BI, baseline impedance measured during high-resolution impedance manometry; MNBI, mean nocturnal baseline impedance; AUC, area under the receiver operating characteristic curve.
Best cutoff points for MNBI at 3 cm above the SCJ were based on maximal Youden index.