Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 1.

High-resolution Manometric Characteristics of Esophageal Primary Peristalsis After Codeine and Placebo Treatment in Patients With Ineffective Esophageal Motility

Characteristics Codeine Placebo P-value
UES parameters (mmHg)
Basal pressure 53.4 (9.3) 39.3 (6.5) 0.136
LES parameters (mmHg)
Basal pressure 23.0 (2.8) 17.5 (1.5) 0.092
IRP-4s 7.9 (1.2) 7.6 (0.7) 0.794
EGJ-CI (mmHg∙cm) 40.7 (5.1) 27.8 (3.4) 0.028a
Esophageal body parameters
DCI (mmHg∙s∙cm) 566.5 (81.2) 247.1 (36.0) 0.001a
Distal latency (sec) 5.7 (0.2) 6.5 (0.1) < 0.001a
Total break length (cm) 4.6 (1.0) 7.4 (0.9) 0.003a
Frequency (%)
Normal peristalsis 53.9 (8.0) 15.0 (3.6) < 0.001a
Weak peristalsis 28.3 (7.2) 45.6 (5.4) 0.039a
Failed peristalsis 17.8 (6.5) 39.4 (6.7) 0.009a
Multiple rapid swallows
Post-MRS DCI (mmHg∙s∙cm) 736.7 (154.4) 550.4 (124.5) 0.129
Contractile reserve (%) 24.1 (5.7) 14.4 (4.5) 0.220
Impaired inhibition (n [%]) 1 (5.6) 0 (0) 0.321

aP-value < 0.05 was a requisite for statistical significance.

UES, upper esophageal sphincter; LES, lower esophageal sphincter; IRP-4s, 4-second integrated relaxation pressure; EGJ-CI, esophagogastric junction–contractile integral; DCI, distal contractile integral; MRS, multiple rapid swallows.

Data are presented as mean (SEM).

J Neurogastroenterol Motil 2024;30:38~45 https://doi.org/10.5056/jnm22131
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