Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 1. Algorithm for evaluation and management of esophageal symptoms suspicious for reflux disease. The concepts of proven gastroesophageal reflux disease (GERD) (prior objective evidence for GERD is present) and unproven GERD (no prior objective evidence for GERD) determine the optimal methodology of investigation of symptoms that persist despite proton pump inhibitor (PPI) therapy. The intent of evaluation of unproven GERD is to determine if GERD exists, while the intent in proven GERD is to determine if GERD persists despite therapy, which may need to be escalated if testing suggests persisting GERD evidence. LA, Los Angeles classification; RH, reflux hypersensitivity; RSA, reflux-symptom association; FH, functional heartburn.
J Neurogastroenterol Motil 2024;30:17~28
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