Fig. 2. Comparison of microbial diversity and structure altered by berberine and rifaximin. (A) The rarefaction curve showing the depth of sequencing data. (B) Chao1 and (C) shannon diversity indexes. (D) Principal coordinate analysis showing microbial structure. (E) Bacterial composition at the phylum level. GH, germ-free (GF) rats receiving fecal microbiota transplantation (FMT) from healthy control, n = 5; GI, GF rats receiving FMT from IBS patients, n = 8; GIBBR, GI rats receiving berberine treatment, n = 8; GIR, GI rats receiving rifaximin treatment, n = 7; OTU, observable taxonomic unit. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
© J Neurogastroenterol Motil
