Fig. 1. Effect of berberine and rifaximin on visceral hypersensitivity. (A) Design of the experiment. (B) Abdominal withdrawal reflex scores in response to colorectal distension. (C) Hematoxylin and eosin staining for distal colonic tissue. (D) Sucrose preference rate reflecting depressive behavior. GF, germ-free; GH, GF rats receiving fecal microbiota transplantation (FMT) from healthy control, n = 5; GI, GF rats receiving FMT from irritable bowel syndrome (IBS) patients, n = 8; GIBBR, GI rats receiving berberine treatment, n = 8; GIR, GI rats receiving rifaximin treatment, n = 7; SPT, sucrose preference test; CRD, colorectal distension. *P < 0.05, **P < 0.01, ****P < 0.0001.
© J Neurogastroenterol Motil
