Different Dilated Intercellular Space Cutoff Results in the Literature
| Study | Method | Subjects | Cutoff value | Results |
|---|---|---|---|---|
| Tobey et al11 | TEM, single length measurement | 13 controls 11 GERD |
2.4 µm | 73% sensitivity 100% specificity |
| Calabrese et al12 | TEM, mean of 100 length measurements | 12 controls 28 GERD 12 duodenal GERD |
0.74 µm | 100% sensitivity 100% specificity |
| Ribolsi et al16 | TEM and LM, mean of 100 length measurements | 12 controls 36 GERD |
TEM: 0.47 µm for distal esophagus | 100% sensitivity 100% specificity No significant correlation in patients between TEM and LM (r = 0.33) |
| Cui et al13 | TEM and LM, mean of 100 length measurements | 42 controls 119 GERD |
LM: 0.85 µm | 93.3% sensitivity 100.0% specificity High consistency between LM and TEM (Kappa = 0.691, P < 0.001) |
| Cui et al14 | LM, mean of 100 length measurements | 44 HC 297 GERD 224 non-GERD |
0.9 µm | 62.6% sensitivity 54.1% specificity |
| LM, histopathologic scores | histopathologic score > 3 | 71.7% sensitivity 47.4% specificity |
||
| Zhou et al15 | LM, mean of 100 length measurements | 352 GERD 284 non-GERD |
0.9 µm | 61.2% sensitivity 56.1% specificity |
| Altaf et al26 (in children) | TEM, mean of 100 measurements | 8 controls 35 NERD |
1.02 µm | 73.0% sensitivity 75.0% specificity |
| LM, area measurement | 8 controls 26 NERD |
11.1% area ratio | 96.0% sensitivity 75.0% specificity |
|
| 13.4% area ratio | 73.0% sensitivity 88.0% specificity |
|||
| Current study | LM, mean of 100 length measurements | 15 HC 115 GERD |
1.12 µm | 63.5% sensitivity 66.7% specificity |
TEM, transmission electron microscopy; GERD, gastroesophageal reflux disease; LM, light microscopy; HC, healthy control; NERD, nonerosive reflux disease.