Fig. 3. Representative pictures of achalasia subtypes and esophagogastric junction outflow obstruction (EGJOO) at high resolution manometry. In all conditions, the common manometric feature is the impaired relaxation of the esophago-gastric junction, as evaluated by a raised IRP. However, in achalasia peristalsis is never intact and it can be either absent (type I), with pan-esophageal pressurizations in at least 20% of wet swallows (type II) or with spastic/premature contractions (type III) in at least 20% of wet swallows (distal latency < 4.5 seconds), while EGJOO patients show normal/intact peristalsis.
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