Fig. 7. Identification of Hub Genes and Pathways through differentially expressed genes (DEGs) protein-protein interaction (PPI) Network Analysis. (A) The PPI network based on DEGs between the patients and controls. The green ellipses represented down-regulated DEGs and the red ellipses represented up-regulated DEGs. (B) Venn plot of the overlapping genes for the top 10 genes selected based on the 5 ranking methods, maximal clique centrality (MCC), maximum neighborhood component (MNC), edge percolated component (EPC), node connect degree (Degree), and Eccentricity. (C) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways displayed as an interaction network using Cytoscape plug-in ClueGO.
© J Neurogastroenterol Motil
