Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 5. Channelrhodopsin-2 (ChR2) regulated the low-frequency and high-amplitude (LFHA) contractions of colonic muscle strips via interstitial cells of Cajal. (A) The effect of ANO1 antagonists, T16Ainh-A01 (10-20 µM), on phasic contractions Kit-ChR2(+) mice. The light evoked LFHA contractions could not be reproduced under T16Ainh-A01 (10 µM). (B) The effect of T16Ainh-A01 on phasic contractions Kit-ChR2(–) mice. The blue rectangles represented the light stimuli, and the red lines represented the administration of T16Ainh-A01. (C) The effect of T16Ainh-A01 (10 µM) on the mean integrated isometric force. ***P < 0.001.
J Neurogastroenterol Motil 2023;29:388~399
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