Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 4.

Summary of the Efficacy and Cautions of Lifestyle Modification and Medical Treatment

Management Level of evidence Strength Cautions
Dietary fiber ++ Slow-transit constipation and defecatory disorders
Exercise +
Bulking agent ++ Insoluble bulking agents (abdominal distention, flatulence)
Magnesium salt +++ Impaired renal function, pregnancy, lactating women
Non-absorbable carbohydrates + Bloating and flatulence
Polyethylene glycol +++ Diarrhea, abdominal pain, and nausea
Stimulant agent ++ Long-term safety and abuse
Probiotics + Immunocompromised patients
Prucalopride +++ Renal and hepatic impairment, elderly
Lubiprostone +++ Nausea, hepatic dysfunction, pregnancy
Linaclotide +++ Diarrhea

+, low; ++, moderate; +++, high; ▲, strong; ▽, conditional.

J Neurogastroenterol Motil 2023;29:271~305
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