Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Disorders of Gut-Brain Interaction in Children 4-18 Years of Age with Down Syndrome and Quality of Life

Diagnosis Criteria met (n =114) Female gender QoLa
Functional constipation 41 (36.0%) 19 (46.3%) 63.4 (15.4)
Irritable bowel syndrome 17 (14.9%) 8 (47.1%) 50.9 (14.0)b
Functional dyspepsia: post-prandial distress syndrome 14 (12.3%) 8 (57.1%) 55.7 (12.0)
Aerophagia 6 (5.3%) 3 (50.0%) 53.8 (8.8)
Abdominal migraine 5 (4.4%) 1 (20.0%) 59.4 (7.7)
Non-retentive fecal incontinence 5 (4.4%) 1 (20.0%) 64.8 (7.7)
Functional vomiting 3 (2.6%) 2 (66.7%) 52.5 (15.3)
Functional dyspepsia: Epigastric pain syndrome 2 (1.8%) 1 (50.0%) 64.1 (15.2)
Functional abdominal pain-NOS 1 (< 1.0%) 1 (100.0%) NA
Functional nausea 1 (< 1.0%) 1 (100.0%) NA
Cyclic vomiting syndrome 1 (< 1.0%) 0 (0.0%) NA
Adolescent rumination syndrome 1 (< 1.0%) 0 (0.0%) NA

aQuality of life (QoL) data only available for 113 subjects.

bIrritable bowel syndrome QoL was lower than any other single diagnosis (P < 0.001).

NOS, not otherwise specified; NA, not applicable.

Data are presented as n (%) or mean (SD).

J Neurogastroenterol Motil 2023;29:94~101 https://doi.org/10.5056/jnm22055
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