Journal of Neurogastroenterology and Motility

Table. 3. Table 3

Correlation Between Neurotransmitters Concentration (Noradrenaline, Dopamine, and Serotonin) and Expression Levels of Transcripts Encoding Genes Involved in the Function of ENS in the Proximal Colon of Control and Stress Mice

Gene mRNA	NA (ng/g)		DA (ng/g)		5-HT (µg/g)
Gene mRNA	r	P-value	r	P-value	r	P-value
Gfap	–0.54	0.048^a	–0.41	0.143	–0.48	0.065
Gdnf	–0.45	0.092	–0.31	0.253	–0.53	0.034^a
Bdnf	–0.57	0.026^a	–0.49	0.067	–0.70	0.003^a
Htr4	0.16	0.576	0.43	0.105	0.31	0.245
Tlr2	–0.57	0.028^a	–0.55	0.033^a	–0.73	0.001^a
Tlr4	–0.06	0.843	0.47	0.088	0.14	0.614

NA, noradrenaline; DA, dopamine; 5-HT, serotonin; Gfap, glial fibrillary acidic protein; Gdnf, glial cell-derived neurotrophic factor; Bdnf, brain-derived neurotrophic factor; Htr4, serotonin receptor 4; Tlr, Toll-like receptor.

aP < 0.05 was considered statistically significant.

J Neurogastroenterol Motil 2023;29:72~84 https://doi.org/10.5056/jnm22009