Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Correlation Between Neurotransmitters Concentration (Noradrenaline, Dopamine, and Serotonin) and Expression Levels of Transcripts Encoding Genes Involved in the Function of ENS in the Proximal Colon of Control and Stress Mice

Gene mRNA NA (ng/g) DA (ng/g) 5-HT (µg/g)
r P-value r P-value r P-value
Gfap –0.54 0.048a –0.41 0.143 –0.48 0.065
Gdnf –0.45 0.092 –0.31 0.253 –0.53 0.034a
Bdnf –0.57 0.026a –0.49 0.067 –0.70 0.003a
Htr4 0.16 0.576 0.43 0.105 0.31 0.245
Tlr2 –0.57 0.028a –0.55 0.033a –0.73 0.001a
Tlr4 –0.06 0.843 0.47 0.088 0.14 0.614

NA, noradrenaline; DA, dopamine; 5-HT, serotonin; Gfap, glial fibrillary acidic protein; Gdnf, glial cell-derived neurotrophic factor; Bdnf, brain-derived neurotrophic factor; Htr4, serotonin receptor 4; Tlr, Toll-like receptor.

aP < 0.05 was considered statistically significant.

J Neurogastroenterol Motil 2023;29:72~84 https://doi.org/10.5056/jnm22009
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