Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 6. Effects of beta-nicotinamide adenine dinucleotide (β-NAD) treatment with apamin pretreatment in the human colon segment. The contractility of the colonic segments did not decrease after the administration of 1.5 mM β-NAD with 500 nM apamin treatment in the right (A) or left colon (C). Similar to the results of adenosine triphosphate (ATP) administration, the amplitude, frequency, or area under the curve (AUC) did not statistically decrease after the administration of 1.5 mM β-NAD with 500 nM apamin pretreatment in the circular muscle (CM) or longitudinal muscle (LM) of the right colonic segment (B) and left colonic segment (D). Control, before 500 nM apamin; Amp, amplitude after 1.5 mM β-NAD; Freq, frequency after 1.5 mM β-NAD; AUC, area under the curve after 1.5 mM β-NAD; Rt, right; Lt, left.
J Neurogastroenterol Motil 2022;28:678~692 https://doi.org/10.5056/jnm21117
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