Fig. 4. Effects of apamin treatment in the human colon segment. After 500 nM apamin administration, the contractility of the colonic segments increased in both the right (A) and left colon (C). In the right colonic segment, after the administration of 500 nM apamin, the amplitude, frequency, and area under the curve (AUC) increased in the circular muscle (CM) and longitudinal muscle (LM), but the differences did not reach statistical significance (B). In the left colonic segment, the frequency significantly increased after 500 nM apamin administration in the CM but not significantly increased in the LM. The AUC in this segment also significantly increased after 500 nM apamin administration in the CM and LM (D). Control, before 500 nM apamin; Amp, amplitude after 500 nM apamin; Freq, frequency after 500 nM apamin; AUC, area under the curve after 500 nM apamin; Rt, right; Lt, left. *P < 0.05.
© J Neurogastroenterol Motil
