Irritable Bowel Syndrome Patients With and Without Visceral Hypersensitivity Defined Based on Cutoff Levels on the Rectal Pain Threshold: Demographics, Disease-related Information and Rectal Sensitivity
| Variable | Patients without hypersensitivity n = 195 |
Patients with hypersensitivity n = 174 |
|
|---|---|---|---|
| Protocol 1 (phasic isobaric distensions) | |||
| Sex (female/male) | 72% vs 28% | 80% vs 20% | 0.071 |
| Age (yr) | 40 (13) | 36.5 (12) | 0.011 |
| IBS duration more than 5 yr (yes/no) | 81% vs 19% | 81% vs 19% | 0.990 |
| Oroanal transit time (day) | 1.7 (1.1) | 1.5 (0.8) | 0.168 |
| IBS subtype | 0.339 | ||
| IBS-C | 25% | 17% | |
| IBS-D | 37% | 42% | |
| IBS-M/U | 38% | 41% | |
| Pressure (mmHg)/volume (mL) threshold first sensation | 9.5 (3.6)/133 (57) | 7.3 (1.6)/119 (34) | < 0.001 |
| Pressure (mmHg)/volume (mL) threshold desire to defecate | 16.6 (7.3)/179 (77) | 10.7 (3.2)/141 (46) | < 0.001 |
| Pressure (mmHg)/volume (mL) discomfort | 27.5 (10.5)/240 (87) | 15.8 (4.7)/175 (63) | < 0.001 |
| Pressure (mmHg)/volume (mL) threshold pain | 42.8 (9.6)/302 (92) | 22.1 (5.1)/214 (72) | < 0.001 |
| Pain intensity at 25 mmHg (VAS score) | 4 (10) | 36 (20) | < 0.001 |
| Protocol 2 (ramp inflation/random phasic distensions) | Patients without hypersensitivity (n = 138) | Patients with hypersensitivity (n = 15) | |
| Sex (female/male) | 67.5% vs 32.5% (n = 138) | 80% vs 20% (n = 15) | 0.318 |
| Age (yr) | 35 (12) | 30 (13) | 0.058 |
| IBS duration more than 5 yr | 27% v s 73% (n = 133) | 53% vs 47% (n = 15) | 0.360 |
| Oro anal transit time (day) | 0.9 (1.4) | 1.1 (2.5) | 0.575 |
| IBS subtype | 0.067 | ||
| IBS-C | 18% | 7% | |
| IBS-D | 36% | 67% | |
| IBS-M/U | 46% | 26% | |
| Pressure (mmHg)/volume (mL) threshold first sensation | 10.8 (6.4)/65 (53) | 4.5 (3.0)/20 (36) | < 0.001 |
| Pressure (mmHg)/volume (mL) threshold desire to defecate | 15.3 (6.5)/108 (61) | 8.7 (3.5)/53 (51) | < 0.001 |
| Pressure (mmHg)/volume (mL) discomfort | 23.0 (7.6)/170 (75) | 11.9 (2.8)/77 (43) | < 0.001 |
| Pressure (mmHg)/volume (mL) threshold pain | 28.7 (8.2)/198 (83) | 14.7 (2.0)/97 (35) | < 0.001 |
| Pain intensity at 24 mmHg (VAS score) | 36 (30) | 47 (33) | 0.267 |
aIndicates a
IBS, irritable bowel syndrome; VAS, visual analogue scale; IBS-C, IBS with constipation; IBS-D, IBS with diarrhea; IBS-M, mixed IBS; IBS-U, unsubtyped IBS.
Data are presented as % or mean (SD).
Statistics calculated using chi-square or Mann-Whitney