Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 5.

Risk of Irritable Bowel Syndrome With Several Definitions of Infantile Colica

Unweighted data (n = 368 556) Weighted data (n = 723 370)b HR (95% CI)e
n (%) n (%)
Control groupc
(n = 359 769)
Infantile colic groupd
(n = 8787)
Control groupc
(n = 363 528)
Infantile colic groupd
(n = 359 842)
Strict IBSf 34 476 (9.6) 1099 (12.5) 34 926 (9.6) 42 246 (11.7) 1.25 (1.23 to 1.28)
IBS-Dg 21 203 (5.9) 699 (7.6) 21 492 (5.9) 25 256 (7.0) 1.20 (1.17 to 1.23)
IBS-Ch 19 184 (5.3) 625 (7.1) 19 438 (5.4) 23 205 (6.5) 1.22 (1.19 to 1.26)
Strict IBS-Di 21 176 (5.9) 668 (7.6) 21 465 (5.9) 25 207 (7.0) 1.20 (1.17 to 1.23)
Strict IBS-Cj 1689 (0.5) 58 (0.7) 1715 (0.5) 1958 (0.5) 1.17 (1.07 to 1.28)

aThe cohort consisted of the infantile colic group who had experienced infantile colic from 5 weeks to 4 months of age and the control group without infantile colic histories during the same time period.

bWeighted using inverse probability of exposure weighting based on the propensity score. The propensity score was estimated using multivariable logistic regression with 97 previously covariates, as defined in Supplementary Table 2. Participants in the reference group were weighted as (propensity score/[1-propensity score]). This method produces a weighted pseudo sample of participants in the reference group with the same distribution of measured covariates as the exposure group.

cAs the reference group, the control group comprises children who had not been diagnosed with infantile colic at 5 weeks to 4 months of age.

dInfantile colic group consists of children who have been diagnosed with infantile colic at least once between 5 weeks and 4 months of age.

eThe hazard ratios (HRs) were assessed using a Cox proportional hazards model to examine the relationship between infantile colic histories and the risk of irritable bowel syndrome (IBS) development in the cohort.

fDefined with at least 1 diagnosis of International Classification of Diseases 10th version (ICD-10) code K58.X (IBS) and R10.X (abdominal pain) and at least 1 of ICD-10 code K59.1 (functional diarrhea), K52.2 (allergic and dietetic gastroenteritis and colitis), K52.8 (other specific noninfective gastroenteritis), or K59.0 (constipation) after the age of 4 years.

gDefined with at least 1 diagnosis of ICD-10 code K58.X (IBS) and R10.X (abdominal pain) and at least 1 diagnosis of ICD code K59.1 (functional diarrhea) after 4 years of age.

hDefined with at least 1 diagnosis of ICD-10 code K58.X (IBS) and R10.X (abdominal pain) and at least 1 diagnosis of ICD code K59.0 (constipation) after 4 years of age.

iDefined with at least 1 diagnosis of ICD-10 code K58.X (IBS) and R10.X (abdominal pain) and at least 1 diagnosis of ICD code K59.1 (functional diarrhea) and at least once of drug classification 237 (antidiarrheal drug) after 4 years of age.

jDefined with at least 1 diagnosis of ICD-10 code K58.X (IBS) and R10.X (abdominal pain) and at least 1 diagnosis of ICD code K59.0 (constipation) and at least once of drug classification 238 (laxative drug) after 4 years of age.

IBS-D, diarrhea-predominant IBS; IBS-C, constipation-predominant IBS.

J Neurogastroenterol Motil 2022;28:618~629 https://doi.org/10.5056/jnm21181
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