Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 4.

Risk of the Irritable Bowel Syndrome According to the Number of Infantile Colica

The number of infantile colic history Unweighted data (n = 368 556) Weighted data (n = 723 370)b
Subjects (n) Events of IBS (n [%]) Subjects (n) Events of IBS (n [%]) HR (95% CI)c
Referent Control groupd 359 769 55 887 (15.5) 363 528 56 547 (15.6) Ref
Exposure 1e 7756 1349 (17.4) 319 475 54 833 (17.2) 1.11 (1.10 to 1.13)
Exposure ≥ 2e 1031 184 (17.9) 40 367 6925 (17.2) 1.11 (1.07 to 1.15)

aThe cohort consists of the infantile colic group who had experienced infantile colic from 5 weeks to 4 months of age and the control group without infantile colic history during the same time period.

bWeighted using inverse probability of exposure weighting based on the propensity score. The propensity score was estimated using multivariable logistic regression with 97 previously covariates, as defined in Supplementary Table 2. Participants in the reference group were weighted as (propensity score/[1-propensity score]). This method produces a weighted pseudo sample of participants in the reference group with the same distribution of measured covariates as the exposure group.

cHazard ratios (HRs) were assessed using a Cox proportional hazards model to examine the relationship between infantile colic history and the risk of irritable bowel syndrome (IBS) in the cohort.

dAs the reference group, the control group comprised children who had not been diagnosed with infantile colic at 5 weeks to 4 months of age.

eInfantile colic group consists of children who have been diagnosed with infantile colic at least once between 5 weeks and 4 months of age.

J Neurogastroenterol Motil 2022;28:618~629
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