Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Comparison of 24-Hour pH-Impedance and High-resolution Manometry Parameters Between Proton Pump Inhibitor Responders and Non-responders of Patients With Acid Exposure Time ≥ 4%

Parameters Responders
(n = 87)
Non-responders
(n = 35)
P-value Responder-NERD
(n = 63)
Non-responder-NERD (n = 28) P-value
24-Hour pH-impedance parameters
AET (%) 8.6 ± 9.9 8.2 ± 12.1 0.849 8.3 ± 10.4 8.5 ± 13.4 0.953
MNBI (Ω) 2121 ± 1045 2212 ± 1075 0.667 2393 ± 1052 2289 ± 1118 0.671
MNBI < 2292 53 (60.9) 20 (57.1) 0.700 32 (50.8) 14 (50.0) 0.944
PSPWi (%) 21.4 ± 13.0 23.0 ± 11.9 0.536 22.2 ± 13.3 22.9 ± 11.9 0.806
PSPWi < 61% 84 (96.6) 35 (100.0) 0.557 60 (95.2) 28 (100) 0.550
Reflux episodes 43.2 ± 34.2 43.9 ± 27.8 0.923 44.1 ± 36.6 36.8 ± 18.5 0.321
Weakly acidic reflux 19.8 ± 22.5 19.4 ± 22.0 0.935 20.6 ± 23.9 14.0 ± 12.1 0.174
Alkaline reflux 0.4 ± 1.7 0.9 ± 2.5 0.248 0.2 ± 1.0 0.4 ± 0.8 0.561
Reflux episodes > 80 9 (10.3) 2 (5.7) 0.509 7 (11.1) 0 (0.0) 0.095
SAP > 95% 36 (41.4) 10 (28.6) 0.187 23 (36.5) 8 (28.6) 0.461
HRM parameters
EGJ II/III 30 (34.5) 6 (17.1) 0.058 17 (27.0) 3 (10.7) 0.084
Hypotensive EGJ 31 (35.6) 12 (34.3) 0.888 21 (33.3) 10 (35.7) 0.825
IEM 52 (59.8) 22 (62.9) 0.752 37 (58.7) 17 (60.7) 0.859

NERD, non-erosive reflux disease; AET, acid exposure time; MNBI, mean nocturnal baseline impedance; PSPWi, post-reflux swallow-induced peristaltic wave index; SAP, symptom association probability; HRM, high-resolution manometry; EGJ, esophagogastric junction; IEM, ineffective esophageal motility.

Data are presented as mean ± SD or n (%).

J Neurogastroenterol Motil 2022;28:580~588 https://doi.org/10.5056/jnm21156
© J Neurogastroenterol Motil