Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 2.

Comparison of Endoscopic, Manometric, and pH-Impedance Parameters of All Participants

Parameters Total
(N = 177)
AET < 4%
(n = 55)
4% ≤ AET ≤ 6%
(n = 69)
AET > 6%
(n = 53)
P-value AET ≥ 4%
(n = 122)
P-value
Endoscopy
Esophagitis 39 (22.0) 8 (14.6) 15 (21.7) 16 (30.2) 0.146 31 (25.4) 0.107
Grade A 17 (9.6) 6 (10.9) 5 (7.3) 6 (11.3) - 11 (9.0) -
Grade B 22 (12.4) 2 (3.6) 10 (14.5) 10 (18.9) - 20 (16.4) -
24-Hour pH-impedance parameters
MNBI (Ω) 2740 ± 1377 4053 ± 1031 2471 ± 1085a,b 1725 ± 840c < 0.001 2147 ± 1050 < 0.001
MNBI < 2292 75 (42.4) 2 (3.6) 31 (44.9)a,b 42 (79.3)c < 0.001 73 (59.8) < 0.001
PSPWi (%) 29.4 ± 20.1 46.2 ± 23.2 26.4 ± 12.2a,b 16.0 ± 10.9c < 0.001 21.9 ± 12.7 < 0.001
PSPWi < 61% 150 (84.7) 31 (56.4) 67 (97.1)a 52 (98.1)c < 0.001 119 (97.5) < 0.001
Reflux episodes 41.4 ± 31.2 37.1 ± 28.0 39.5 ± 25.7 48.5 ± 39.1 0.131 43.4 ± 32.4 0.210
Weakly acidic reflux 21.6 ± 21.7 25.9 ± 19.8 18.4 ± 18.1 21.3 ± 26.9 0.161 19.7 ± 22.3 0.077
Alkaline reflux 0.8 ± 2.6 1.4 ± 3.5 0.7 ± 2.3 0.4 ± 1.5 0.118 0.6 ± 2.0 0.106
Reflux episodes > 80 12 (6.8) 1 (1.8) 4 (5.8) 7 (13.2)c 0.057 11 (9.0) 0.108
SAP > 95% 64 (36.2) 18 (32.7) 21 (30.4) 25 (47.2) 0.132 46 (37.7) 0.524
HRM parameters
EGJ II/III 41 (23.2) 5 (9.1) 18 (26.1)a 18 (34.0)c 0.007 36 (29.5) 0.003
Hypotensive EGJ 57 (32.2) 14 (25.5) 28 (40.6) 15 (28.3) 0.155 43 (35.3) 0.197
IEM 96 (54.2) 22 (40.0) 42 (60.9)a 32 (60.4)c 0.038 74 (60.7) 0.011

aP < 0.05 for acid exposure time (AET) < 4% and 4% ≤ AET ≤ 6%.

bP < 0.05 for AET > 6% and 4% ≤ AET ≤ 6%.

cP < 0.05 for AET < 4% and AET > 6%.

MNBI, mean nocturnal baseline impedance; PSPWi, post-reflux swallow-induced peristaltic wave index; SAP, symptom association probability; HRM, high-resolution manometry; EGJ, esophagogastric junction; IEM, ineffective esophageal motility.

Data are presented as n (%) or mean ± SD.

J Neurogastroenterol Motil 2022;28:580~588 https://doi.org/10.5056/jnm21156
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