Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 7.

Comparison of Patients’ Characteristics Between Recurrent and Treatment-naive Achalasia Patientsa

Variables Failure of BD (n = 344) Failure of HM (n = 48) Treatment-naive (n = 1580) P (BD vs HM) P (BD vs naive) P (HM vs naive)
Sex (male) 163 (47.4%) 24 (50.0%) 800 (50.6%) 0.760 0.285 1.000
Age at onset (≥ 40 yr) 163 (47.4%) 8 (16.7%) 792 (50.1%) < 0.001 0.372 < 0.001
Age at presentation (≥ 65 yr) 90 (26.2%) 19 (39.6%) 324 (20.5%) 0.059 0.025 0.003
Disease duration (≥ 10 yr) 145 (42.2%) 43 (89.6%) 369 (23.4%) < 0.001 < 0.001 < 0.001
BMI (≥ 25 kg/m2) 55 (16.0%) 10 (20.8%) 236 (14.9%) 0.408 0.619 0.303
Type I achalasia 245 (71.2%) 39 (81.2%) 937 (59.3%) 0.169 < 0.001 0.002
IRP (< 26 mmHg) 228 (66.3%) 40 (83.3%) 675 (42.7%) 0.020 < 0.001 < 0.001
Calcium channel blocker use 26 (19.3%) 4 (22.2%) 81 (11.7%) 0.756 0.024 0.256
Nitrite use 6 (4.4%) 0 (0.0%) 20 (2.9%) 1.000 0.415 1.000
Esophageal dilation (≥ II) 214 (62.2%) 28 (58.3%) 945 (59.8%) 0.636 0.430 0.882
Type of achalasia (sigmoid) 91 (26.5%) 20 (41.7%) 263 (16.6%) 0.039 < 0.001 < 0.001

aRecurrent cases are defined as patients having Eckardt score ≥ 4 after achalasia interventions, and patient characteristics are compared between these patients and treatment-naive patients having Eckardt score ≥ 4.

Esophageal dilation: the grade of esophageal dilation based on maximum transverse diameter (d) using barium esophagogram. Grade I: d < 3.5 cm, grade II: 3.5 cm ≤ d < 6.0 cm, grade III: d ≥ 6.0 cm. Calcium channel blocker use and nitrite use are analyzed in 845 patients and 841 patients, respectively.

BD, balloon dilatation; HM, Heller myotomy; BMI, body mass index; IRP, integrated relaxation pressure.

J Neurogastroenterol Motil 2022;28:562~571 https://doi.org/10.5056/jnm21254
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