Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Characteristics of Treatment-naive Achalasia Patients Diagnosed Using the Starlet High-resolution Manometry System (n = 1824)

Variables Type I (n = 1073) Type II (n = 663) Type III (n = 88) P (Type I vs II) P (Type I vs III) P (Type II vs III)
Sex (male) 540 (50.3%) 330 (49.8%) 49 (55.7%) 0.843 0.375 0.309
Age at onset (≥ 40 yr) 538 (50.1%) 339 (51.1%) 69 (78.4%) 0.693 < 0.001 < 0.001
Age at diagnosis (≥ 65 yr) 231 (21.5%) 125 (18.9%) 51 (58.0%) 0.199 < 0.001 < 0.001
Disease duration (≥ 10 yr) 283 (26.4%) 145 (21.9%) 22 (25.0%) 0.039 0.900 0.497
Eckardt score (≥ 4)a 937 (89.9%) 575 (89.4%) 68 (78.2%) 0.742 0.002 0.004
Dysphagia 1033 (99.1%) 633 (98.4%) 87 (100.0%) 0.236 1.000 0.617
Regurgitation 945 (90.7%) 583 (90.7%) 74 (85.1%) > 0.999 0.092 0.125
Chest pain 682 (65.5%) 452 (70.3%) 48 (55.2%) 0.042 0.062 0.007
Weight loss 656 (63.0%) 384 (59.7%) 42 (48.3%) 0.197 0.008 0.049
BMI (≥ 25 kg/m2) 152 (14.2%) 102 (15.4%) 16 (18.2%) 0.485 0.343 0.532
IRP (< 26 mmHg) 572 (53.3%) 193 (29.1%) 31 (35.2%) < 0.001 0.001 0.264
Calcium channel blocker usea 63 (12.5%) 24 (9.8%) 12 (23.1%) 0.331 0.052 0.017
Nitrite usea 14 (2.8%) 7 (2.9%) 1 (1.9%) > 0.999 >0.999 > 0.999
Esophageal dilation (≥ II) 708 (66.0%) 331 (49.9%) 15 (17.0%) < 0.001a < 0.001 < 0.001
Type of achalasia (sigmoid) 227 (21.2%) 72 (10.9%) 9 (10.2%) < 0.001a 0.013 > 0.999

aMissing values of Eckardt score: 52. Calcium channel blocker use and nitrite use are analyzed in 798 and 796 patients, respectively. Esophageal dilation: the grade of esophageal dilation based on maximum transverse diameter (d) using barium esophagogram. Grade I: d < 3.5 cm, grade II: 3.5 cm ≤ d < 6.0 cm, grade III: d ≥ 6.0 cm.

BMI, body mass index; IRP, integrated relaxation pressure.

J Neurogastroenterol Motil 2022;28:562~571 https://doi.org/10.5056/jnm21254
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