Summary of Clinical Studies Investigating the Bile Acid Profiles and Fecal Microbiota in Irritable Bowel Syndrome
| Study | Participants (n) | Fecal BA profile | Fecal microbiota |
|---|---|---|---|
| Wong et al (2012)139 | HC (26), IBS-C (26), and IBS-D (26) |
Higher total BA in IBS-D than in IBS-C but not than in HC Total BA correlated with stool weight and fat |
Not investigated |
| Duboc et al (2012)16 | HC (18) and IBS-D (14) |
Similar total BA in IBS-D and HC Increased PBA (%) and decreased SBA (%) in IBS-D than in HC |
Decreased the Increased |
| Shin et al (2013)140 | HC (30), IBS-C (30), and IBS-D or FD (31) |
Increased total UBA in IBS-D than in IBS-C but not than in HC Higher primary UBA (%) in IBS-D than in HC Lower secretory CDCA and DCA (%) in IBS-C than in HC Higher non-secretory secondary LCA (%) in IBS-C than in HC |
Not investigated |
| Dior et al (2016)36 | HC (15), IBS-C (15), and IBS-D (16) |
No differences of total BAs among the three groups Increased PBAs and decreased SBAs in IBS-D compared to HC Increased sulfated BAs and UDCA in IBS-D compared to HC Increased CDCA, sulfated BAs, and UDCA in IBS-D compared to IBS-C |
No differences in the total fecal bacteria counts in the 3 groups Increased relative counts of Increased relative counts of |
| Zhao et al (2020)137 | HC (89) and IBS-D (290) |
Increased total BA in IBS-D than in HC Increased amounts of CA, CDCA, DCA, LCA, 7-KDCA, UDCA, and ωMCA and increased % of CA, CDCA, UDCA, and 7-KDCA and decreased % of LCA and 12-KLCA in IBS-D with high BA excretion compared with HC |
Increased abundances of Clostridia bacteria, Positive correlation of the abundances of Clostridia genera and |
| Wei et al (2020)136 | HC (28) and IBS-D (55) |
Increased total fecal BA in IBS-D than in HC Increased PBAs and decreased SBAs in IBS-D than in HC Decreased LCA in IBS-D than in HC Increased CBAs, UBAs, and ratio of CBAs/UBAs in IBS-D |
Increased Proteobacteria, Gammaproteobacteria, Enterobacteriales, and Enterobacteriaceae and decreased Clostridia, Clostridiales, and Ruminococcaceae in IBS-D Decreased 9 genera including 5 from Ruminococcaceae in IBS-D Negative correlation of PBAs and positive correlation of SBAs with 8 genera among decreased 9 |
| Wei et al (2021)138 | HC (32) and IBS-D (52) |
Increased total fecal BA in IBS-D than in HC Increased PBAs and decreased SBAs in IBS-D than in HC |
Not investigated |
| James et al (2021)141 | HC (97), IBS-D (52), and IBS-C (24) |
Increased CA in IBS-D than in HC but not in IBS-C Increased CDCA in IBS-D than in IBS-C and in HC Decreased GCA in IBS-C than in IBS-D and in HC |
Not investigated |
BA, bile acid; HC, healthy control; IBS-C, constipation-predominant irritable bowel syndrome; IBS-D, diarrhea-predominant irritable bowel syndrome; PBA, primary bile acid; SBA, secondary bile acid;