Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 1.

Short Chain Fatty Acids Receptors Involved in Irritable Bowel Syndrome

Receptor G protein Ligand Cell Refs
GPR41 (FFA3) Gi/o Acetate, propionate, and butyrate Enteroendocrine cells (L cells) and neuronal cells 23-24, 26, 29, 30
GPR43 (FFA2) Gi/o, Gq Acetate, propionate, and butyrate Enteroendocrine cells, (enterochromaffin cells and L cells), mast cells, and immune cells (neutrophils and eosinophils) 23-24, 27, 28, 29
GPR109A Gi Butyrate Intestinal epithelial cells and immune cells (neutrophils and macrophages) 23-25, 31

GPR, G protein coupled receptors; FFA, free fatty acid receptors.

J Neurogastroenterol Motil 2022;28:540~548 https://doi.org/10.5056/jnm22093
© J Neurogastroenterol Motil