Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 2.

Selective Short Chain Fatty Acid Receptor Agonists Involved in Irritable Bowel Syndrome

Agonist Receptor Function Model Refs
AR420626 GPR41 Stimulate anion secretion, suppress neural activity, and inhibit muscle contractions Rat 66, 99
4-CMTB GPR43 Stimulate anion secretion Rat 99
AZ1729 GPR43 Activated and desensitize of neutrophils Human neutrophil 101
phenylacetamide-1 GPR43 Modulate the intestinal mucosa protection Mice 102
Compound 1 GPR43 Slow intestinal transit Mice 71
Compound 58 GPR43 Activate and desensitize of neutrophils Human neutrophil 101
Compound 110 GPR43 Attenuate intestinal inflammation Mice 100
Compound 187 GPR43 Attenuate intestinal inflammation Mice 100

GPR, G protein coupled receptors.

J Neurogastroenterol Motil 2022;28:540~548 https://doi.org/10.5056/jnm22093
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