Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Esophageal Motor Dysfunction in Gastroesophageal Reflux Disease and its Association With Reflux

Esophageal motor dysfunction Reflux relationship
Impaired anti-reflux barrier at EGJ
- Frequent TLESR ↑ Postprandial reflux14
- Hypotensive LES ↑ Reflux esophagitis15
- Low EGJ-CI ↑ Acid reflux
↑ Reflux esophagitis17-20
- Hiatal hernia ↑ Acid exposure time
↑ Positive reflux-symptom association17,18
Esophageal body dysmotility
- Ineffective primary peristalsis ↑ Acid, weakly-acidic reflux
↑ Reflux esophagitis21,25,26
- Decreased effective secondary peristalsis ↑ Refractory GERD
↑ Reflux esophagitis27,28
- Abnormal multiple rapid swallowing ↑ Acid exposure time29

EGJ, esophagogastric junction; TLESR, transient lower esophageal relaxation; LES, lower esophageal sphincter; EGJ-CI, esophagogastric junction-contractile integral; GERD, gastroesophageal reflux disease.

J Neurogastroenterol Motil 2022;28:531~539 https://doi.org/10.5056/jnm22082
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