Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Bristol Stool Form Scale Score, Patient Satisfaction, and Symptoms of Constipation, Fecal Disimpaction, and Time to Bowel Movements After Treatment With Elobixibat

Item Baseline (n = 986) Week 2 (n = 986) Week 4 (n = 986)
Bristol Stool Form Scale score 2.3 ± 1.4 (888) 3.8 ± 1.3a (778) 3.9 ± 1.1a (817)
Patient satisfaction
Satisfaction 6 (0.7) 222 (28.1) 324 (38.9)
Slight satisfaction 51 (5.6) 300 (38.0) 317 (38.1)
Slight dissatisfaction 297 (32.7) 164 (20.8) 118 (14.2)
Dissatisfaction 553 (61.0) 103 (13.1) 73 (8.8)
No evaluation 79 (−) 197 (−) 154 (−)
Abdominal distension
No 64 (7.2) 175 (22.4) 232 (28.3)
Rarely 165 (18.7) 309 (39.5) 355 (43.2)
Occasionally 326 (36.9) 231 (29.5) 193 (23.5)
Often 229 (25.9) 49 (6.3) 28 (3.4)
Always 99 (11.2) 18 (2.3) 13 (1.6)
No evaluation 103 (−) 204 (−) 165 (−)
Straining during defecation, n (%)
No 42 (4.9) 148 (19.2) 190 (23.5)
Rarely 102 (11.9) 289 (37.5) 318 (39.3)
Occasionally 266 (31.0) 221 (28.7) 212 (26.2)
Often 278 (32.4) 69 (8.9) 55 (6.8)
Always 171 (19.9) 44 (5.7) 34 (4.2)
No evaluation 127 (−) 215 (−) 177 (−)
Fecal disimpaction
No 805 (88.6) 757 (95.9) 803 (96.6)
Yes 104 (11.4) 32 (4.1) 28 (3.4)
No evaluation 77 (−) 197 (−) 155 (−)
Time to bowel movement (hr)
Mean ± SD (n) ND 6.1 ± 6.0 (415) 6.4 ± 5.9 (439)
Median 6.0 6.0

aP < 0.001 vs baseline, Wilcoxon signed-rank test for Bristol Stool Form Scale score.

ND, not determined; n, number of patients with each item at each visit.

Data are presented as mean ± SD (n) or n (%).

J Neurogastroenterol Motil 2022;28:431~441 https://doi.org/10.5056/jnm20263
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