Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 2.

Changes in Gut Hormones After Subtotal Gastrectomy in Patients With Stomach Cancer

Parameter Pre-operative state Post-operative 4 months Post-operative 12 months 0-4 month change 4-12 month change 0-12 month change
Means 95% CI Means 95% CI Means 95% CI P for Wilcoxon signed-rank testa
InsulinAUC (IU/mL × min) 5.8 4.1-8.2 11.2 6.0-21.1 11.9 6.2-22.6 0.075 0.183 0.529
Insulinpeak (μIU/mL) 81.3 58.4-113.2 168.4 88.0-322.2 266.4 99.7-433.1 0.052 0.054 0.054
GhrelinAUC (ng/mL × min) 631.0 440.8-821.1 857.7 621.0-1094.3 907.0 727.2-1086.8 0.052 > 0.999 0.084
Ghrelinpeak (ng/mL) 5.2 3.6-6.7 7.1 5.2-8.9 7.4 5.8-8.9 0.101 > 0.999 0.084
GLP-1AUC (μg/mL × min) 1.7 1.1-2.5 2.6 1.5-4.4 2.6 1.3-5.5 0.035 > 0.999 > 0.999
GLP-1peak (ng/mL) 23.4 15.9-34.5 38.9 21.9-69.0 38.3 17.0-86.4 0.035 > 0.999 > 0.999
GIP-1AUC (μg/mL × min) 2.8 1.2-6.6 8.0 4.0-15.7 9.2 3.4-2.4 0.035 > 0.999 0.519
GIP-1peak (ng/mL) 32.1 11.4-90.3 115.5 58.1-229.6 113.9 35.3-367.6 0.084 > 0.999 0.519
PYYAUC (ng/mL × min) 5.0 3.2-7.7 11.0 4.7-25.9 3.1 1.1-8.2 0.107 0.347 > 0.999
PYYpeak (pg/mL) 45.4 31.4-65.7 95.6 43.2-211.7 42.03 15.5-114.1 0.035 > 0.999 > 0.999
HOMA-IR 2.2 1.3-3.6 2.1 1.1-4.2 2.0 1.2-2.7 > 0.999 0.129 0.0831

aP for Wilcoxon signed-rank test with multiple comparison.

AUC, area under curve; GLP-1, glucagon like peptide-1; GIP-1, gastric inhibitory peptide-1; PYY, Peptide YY; HOMA-IR, homeostatic model assessment for insulin resistance.

J Neurogastroenterol Motil 2022;28:409~417 https://doi.org/10.5056/jnm21145
© J Neurogastroenterol Motil