Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 1.

Baseline Characteristics and Hormone Levels Between Subjects Scheduled for Subtotal Gastrectomy and 14 Controls

Parameter Subtotal gastrectomy (n = 13) Controls (n = 14) P-value
Age (yr) 59.2 ± 10.4 (45-75) 49.6 ± 5.8 (36-56) < 0.001
Sex (M:F) 8:5 7:7 0.411
BMI (kg/m2) 24.6 ± 2.8 22.5 ± 2.3 < 0.001
< 25 8 13
25-30 5 1
Baseline hormone levels
InsulinAUC (IU/mL × min) 5.8 (4.1-8.2) 6.6 (5.8-7.5) 0.165
Insulinpeak (μIU/mL) 81.3 (58.4-113.2) 100.4 (88.0-114.7) 0.040
GhrelinAUC (ng/mL × min) 631.0 (440.8-821.1) 555.8 (362.9-748.7) 0.488
Ghrelinpeak (ng/mL) 5.2 (3.6-6.7) 4.6 (3.0-6.1) 0.564
GLP-1AUC (μg/mL × min) 1.7 (1.1-2.5) 2.3 (1903.0-2798.8) 0.031
GLP-1peak (ng/mL) 23.4 (15.9-34.5) 35.1 (28.9-42.7) 0.024
GIP-1AUC (μg/mL) 2.8 (1.2-6.6) 9.1 (7.3-11.3) 0.005
GIP-1peak (ng/mL) 32.1 (11.4-90.3) 138.1 (110.3-172.9) 0.010
PYYAUC (ng/mL × min) 5.0 (3.2-7.7) 1.6 (5.9-4.4) 0.013
PYYpeak (pg/mL) 45.4 (31.4-65.7) 37.6 (13.4-104.9) 0.621
HOMA-IR 2.2 (1.3-3.6) 2.0 (1.8-2.3) 0.381

M, male; F, female; BMI, body mass index; AUC, area under curve; GLP-1, glucagon like peptide-1; GIP-1, gastric inhibitory peptide; PYY, Peptide YY; HOMA-IR, homeostatic model assessment for insulin resistance.

Age, sex, and BMI are presented as mean ± SD (range), n, or mean (95% CI).

J Neurogastroenterol Motil 2022;28:409~417 https://doi.org/10.5056/jnm21145
© J Neurogastroenterol Motil