Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Changes in Gut Hormones According to the Presence of Dumping Syndrome at Post-operative 12 Months

Parameter No dumping syndrome (n = 11) Dumping syndrome (n = 3) P-valuea
25th percentile 50th percentile 75th percentile 25th percentile 50th percentile 75th percentile
Pre-operative weight (kg) 49.3 57.3 63.9 77.8 80.0 84.4 0.050
Post-operative weight (kg) 47.3 57.3 60.2 59.1 70.0 77.7 0.275
Pre-operative gut hormones
InsulinAUC (IU/mL × min) 3.8 4.4 5.2 5.3 5.6 5.9 0.564
Insulinpeak (μIU/mL) 54.8 65.6 70.5 74.8 77.4 79.9 0.258
GhrelinAUC (ng/mL × min) 544.5 710.5 838.1 372.4 409.6 446.8 0.248
Ghrelinpeak (ng/mL) 4.7 6.2 6.9 3.0 3.1 3.3 0.248
GLP-1AUC (μg/mL × min) 1.0 1.2 1.3 1.3 1.6 1.9 0.258
GLP-1peak (ng/mL) 13.3 15.5 15.8 15.7 21.4 27.1 0.248
GIP-1AUC (μg/mL × min) 0.5 0.5 2.3 2.3 3.4 4.5 0.248
GIP-1peak (ng/mL) 2.1 10.0 18.0 19.6 36.4 53.3 0.121
PYYAUC (ng/mL × min) 6.1 6.4 9.5 2.5 2.9 3.3 0.083
PYYpeak (pg/mL) 62.2 75.4 93.8 25.5 31.2 36.9 0.083
Post-operative gut hormones
InsulinAUC (IU/mL × min) 7.7 10.6 17.5 7.7 10.9 20.1 0.827
Insulinpeak (μIU/mL) 119.5 169.2 281.0 115.7 161.8 322.5 0.827
GhrelinAUC (ng/mL × min) 588.9 595.7 978.8 843.9 907.5 928.3 0.513
Ghrelinpeak (ng/mL) 4.9 5.2 8.2 6.8 7.0 7.4 0.513
GLP-1AUC (μg/mL × min) 1.4 2.1 4.1 1.4 2.1 4.3 0.827
GLP-1peak (ng/mL) 21.9 33.9 66.3 20.6 30.8 69.9 0.827
GIP-1AUC (μg/mL × min) 6.7 11.9 18.1 3.7 5.9 14.9 0.513
GIP-1peak (ng/mL) 105.6 191.4 293.1 52.0 85.0 241.8 0.827
PYYAUC (ng/mL × min) 6.1 6.4 9.5 2.5 2.9 3.3 0.083
PYYpeak (pg/mL) 62.2 75.4 93.8 25.5 31.2 36.9 0.083

aP-value for Mann-Whitney U test.

The hormone levels are presented by quartiles of log-transformed values: Q2, 25th percentiles; Q3, median; Q4, 75th percentiles; AUC, area under curve; GLP-1, glucagon like peptide-1; GIP-1, gastric inhibitory peptide; PYY, Peptide YY.

J Neurogastroenterol Motil 2022;28:409~417 https://doi.org/10.5056/jnm21145
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