Factors Associated With Disease Specific Quality of Life in Eosinophilic Esophagitis Patients
| Disease specific quality of life (EoE-QOL-A) N = 147 |
Univariate analysis | Multivariable analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|
| B | b | 95% CI (B) | B | b | 95% CI (B) | ||||
| Eating/diet impact | |||||||||
| Female gender | –0.589 | –0.257 | –0.953 to –0.225 | 0.002 |
–0.374 | –0.163 | –0.715 to –0.034 | 0.031 |
|
| Age | 0.025 | 0.313 | 0.013 to 0.038 | < 0.001 |
0.018 | 0.229 | 0.007 to 0.030 | 0.002 |
|
| Severe clinical disease activity | –1.301 | –0.330 | –1.911 to –0.691 | < 0.001 |
–1.053 | –0.267 | –1.625 to –0.481 | < 0.001 |
|
| Dietary restrictions | –0.696 | –0.294 | –1.069 to –0.324 | < 0.001 |
–0.496 | –0.209 | –0.850 to –0.142 | 0.006 |
|
| Disease duration |
0.075 | 0.269 | 0.031 to 0.119 | 0.001 |
NS | ||||
| Adapted eating behavior | –0.497 | –0.213 | –0.871 to –0.124 | 0.009 |
NS | ||||
| Social impact | |||||||||
| Age | 0.01 | 0.142 | -0.001 to 0.02 | 0.086 |
NS | ||||
| Severe clinical disease activity | –1.067 | –0.323 | –1.580 to –0.553 | < 0.001 |
–1.062 | –0.321 | –1.571 to –0.553 | < 0.001 |
|
| Disease duration |
0.031 | 0.131 | –0.007 to 0.069 | 0.114 |
NS | ||||
| Number of endoscopic interventions with food bolus extraction | –0.072 | –0.154 | –0.148 to 0.004 | 0.062 |
NS | ||||
| Adapted eating behavior | –0.218 | –0.111 | –0.537 to 0.101 | 0.179 |
NS | ||||
| Emotional impact | |||||||||
| Female gender | –0.504 | –0.275 | –0.793 to –0.214 | 0.001 |
–0.446 | –0.212 | –0.769 to –0.122 | 0.007 |
|
| Age | 0.018 | 0.283 | 0.008 to 0.028 | 0.001 |
0.016 | 0.236 | 0.005 to 0.025 | 0.003 |
|
| Severe clinical disease activity | –0.828 | –0.263 | –1.326 to –0.330 | 0.001 |
–0.604 | –0.199 | –1.103 to –0.146 | 0.011 |
|
| Disease duration |
0.055 | 0.248 | 0.02 to 0.090 | 0.002 |
NS | ||||
| Adapted eating behavior | –0.232 | –0.125 | –0.535 to 0.071 | 0.132 |
NS | ||||
| Disease anxiety | |||||||||
| Female gender | –0.478 | –0.228 | –0.814 to –0.143 | 0.006 |
–0.446 | –0.212 | –0.769 to –0.122 | 0.007 |
|
| Age | 0.019 | 0.256 | 0.007 to 0.030 | 0.002 |
0.015 | 0.204 | 0.003 to 0.027 | 0.001 |
|
| Severe clinical disease activity | –0.422 | –0.117 | –1.009 to 0.166 | 0.158 |
NS | ||||
| Disease duration |
0.061 | 0.239 | 0.02 to 0.101 | 0.004 |
0.044 | 0.172 | 0.001 to 0.086 | 0.043 |
|
| Number of endoscopic interventions with food bolus extraction | –0.060 | –0.117 | –0.143 to 0.023 | 0.157 |
–0.100 | –0.196 | –0.179 to –0.021 | 0.014 |
|
| Swallowing anxiety | |||||||||
| Age | 0.018 | 0.244 | 0.006 to 0.03 | 0.003 |
0.015 | 0.186 | 0.002 to 0.025 | 0.02 |
|
| Severe clinical disease activity | –1.095 | –0.304 | –1.660 to –0.531 | < 0.001 |
–0.913 | –0.253 | –1.477 to –0.350 | 0.002 |
|
| Disease duration |
0.038 | 0.148 | –0.004 to 0.079 | 0.074 |
NS | ||||
| Adapted eating behavior | –0.397 | –0.186 | –0.741 to –0.052 | 0.024 |
NS | ||||
a
b
cDisease duration = measured from year of diagnosis.
EoE-QOL-A, adult eosinophilic esophagitis quality of life questionnaire; B, unstandardized regression coefficient, where 1 point increase in the predictor variable (eg, female gender) is associated with B point(s) increase in the dependent variable (EoE-QOL-A subscale score); ß, standardized regression coefficient, where 1 standard deviation increase in the predictor variable (eg, female gender) is associated with ß point(s) increase in the dependent variable (EoE-QOL-A subscale score); NS, not significant.