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Table. 2.

Factors Associated With Disease Specific Quality of Life in Eosinophilic Esophagitis Patients

Disease specific quality of life (EoE-QOL-A)
N = 147
Univariate analysis Multivariable analysis
B b 95% CI (B) P-value B b 95% CI (B) P-value
Eating/diet impact
Female gender –0.589 –0.257 –0.953 to –0.225 0.002a –0.374 –0.163 –0.715 to –0.034 0.031a
Age 0.025 0.313 0.013 to 0.038 < 0.001a 0.018 0.229 0.007 to 0.030 0.002a
Severe clinical disease activity –1.301 –0.330 –1.911 to –0.691 < 0.001a –1.053 –0.267 –1.625 to –0.481 < 0.001a
Dietary restrictions –0.696 –0.294 –1.069 to –0.324 < 0.001a –0.496 –0.209 –0.850 to –0.142 0.006a
Disease durationc 0.075 0.269 0.031 to 0.119 0.001a NS
Adapted eating behavior –0.497 –0.213 –0.871 to –0.124 0.009a NS
Social impact
Age 0.01 0.142 -0.001 to 0.02 0.086b NS
Severe clinical disease activity –1.067 –0.323 –1.580 to –0.553 < 0.001a –1.062 –0.321 –1.571 to –0.553 < 0.001a
Disease durationc 0.031 0.131 –0.007 to 0.069 0.114b NS
Number of endoscopic interventions with food bolus extraction –0.072 –0.154 –0.148 to 0.004 0.062b NS
Adapted eating behavior –0.218 –0.111 –0.537 to 0.101 0.179b NS
Emotional impact
Female gender –0.504 –0.275 –0.793 to –0.214 0.001a –0.446 –0.212 –0.769 to –0.122 0.007a
Age 0.018 0.283 0.008 to 0.028 0.001a 0.016 0.236 0.005 to 0.025 0.003a
Severe clinical disease activity –0.828 –0.263 –1.326 to –0.330 0.001a –0.604 –0.199 –1.103 to –0.146 0.011a
Disease durationc 0.055 0.248 0.02 to 0.090 0.002a NS
Adapted eating behavior –0.232 –0.125 –0.535 to 0.071 0.132b NS
Disease anxiety
Female gender –0.478 –0.228 –0.814 to –0.143 0.006a –0.446 –0.212 –0.769 to –0.122 0.007a
Age 0.019 0.256 0.007 to 0.030 0.002a 0.015 0.204 0.003 to 0.027 0.001a
Severe clinical disease activity –0.422 –0.117 –1.009 to 0.166 0.158b NS
Disease durationc 0.061 0.239 0.02 to 0.101 0.004a 0.044 0.172 0.001 to 0.086 0.043a
Number of endoscopic interventions with food bolus extraction –0.060 –0.117 –0.143 to 0.023 0.157b –0.100 –0.196 –0.179 to –0.021 0.014a
Swallowing anxiety
Age 0.018 0.244 0.006 to 0.03 0.003a 0.015 0.186 0.002 to 0.025 0.02a
Severe clinical disease activity –1.095 –0.304 –1.660 to –0.531 < 0.001a –0.913 –0.253 –1.477 to –0.350 0.002a
Disease durationc 0.038 0.148 –0.004 to 0.079 0.074b NS
Adapted eating behavior –0.397 –0.186 –0.741 to –0.052 0.024a NS

aP-value of < 0.05, indicating a significant outcome.

bP-value < 0.2, indicating a possible trend.

cDisease duration = measured from year of diagnosis.

EoE-QOL-A, adult eosinophilic esophagitis quality of life questionnaire; B, unstandardized regression coefficient, where 1 point increase in the predictor variable (eg, female gender) is associated with B point(s) increase in the dependent variable (EoE-QOL-A subscale score); ß, standardized regression coefficient, where 1 standard deviation increase in the predictor variable (eg, female gender) is associated with ß point(s) increase in the dependent variable (EoE-QOL-A subscale score); NS, not significant.

J Neurogastroenterol Motil 2022;28:390~400 https://doi.org/10.5056/jnm21143
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