Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 2. A lower number of phosphorylated extracellular signal-regulated kinase (p-ERK)–immunoreactive (ir) neurons were observed in spinal cord (T9-T10) after treatment with Yokukansan (YKS) in maternal separation (MS) rats. (A) Representative pictures of p-ERK–ir neurons in the dorsal horn 2 minutes after gastric distention at 80 mmHg in each group. We magnified the lamina I and II layer of the dorsal horn (dotted square), (B) the black arrows indicate p-ERK1/2–ir cells. (C) The bar graph shows the statistics of positive cells in each group at a pressure of 80 mmHg (control-veh, n = 3, control-YKS, n = 4, MS-veh, n = 4, MS-YKS, n = 4. Data were analyzed by unpaired t test. *P < 0.05, ***P < 0.001; data are presented as the mean ± SEM; scale bar: 50 μm).
J Neurogastroenterol Motil 2022;28:255~264 https://doi.org/10.5056/jnm21204
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