Fig. 1. Yokukansan (YKS) inhibited hypersensitivity to gastric distention (GD) induced by neonatal maternal separation (MS) stress. (A) Schedule for MS and drug treatment. MS treatment was performed from postnatal day (PND) 1 to 10, and YKS was administered from PND 49 to 56. (B) Sample trace of electromyography (EMG) response to different GD pressures in each group (black line, control-veh; blue line, control-YKS; orange line, MS-veh; green line, MS-YKS). (C) Doted-line graph shows the statistics of EMG response in each group (control-veh, n = 5; control-YKS, n = 5; MS-veh, n = 5; MS-YKS, n = 7). Data were analyzed by one-way ANOVA. *P < 0.05, MS-veh vs MS-YKS at 80 mmHg; #P < 0.05, MS-veh vs control-veh at 80 mmHg. Data are presented as the mean ± SEM.
© J Neurogastroenterol Motil
