Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 4.

Distribution of Genetic Polymorphisms Between Control and Functional Gastrointestinal Disorders

Genotypes Controls FGID
Total P-value Men P-valuea Women P-valueb
SLC6A4 5-HTTLPR NERD-FD-IBS
S/S 92 (70.2) 27 (54.0) 0.049 12 (63.2) 0.681 15 (48.4) 0.024
L/S 35 (26.7) 18 (36.0) 7 (36.8) 11 (35.5)
L/L 4 (3.1) 5 (10.0) 0 (0.0) 5 (16.1)
SLC6A4 3609A>G NERD-FD-IBS
A/A 187 (89.5) 41 (75.9) 0.001 15 (75.0) 0.147 26 (76.5) 0.028
A/G 22 (10.5) 12 (22.2) 5 (25.0) 7 (20.6)
G/G 0 (0.0) 1 (1.9) 0 (0.0) 1 (2.9)
GNB3 825C>T IBS only
C/C 50 (23.8) 5 (12.8) 0.035 2 (9.5) 0.269 3 (16.7) 0.181
C/T 98 (46.7) 27 (69.3) 15 (71.4) 12 (66.7)
T/T 62 (29.5) 7 (17.9) 4 (19.0) 3 (16.7)
GNB3 825C>T NERD-FD-IBS
C/C 50 (23.8) 21 (38.9) 0.043 9 (45.0) 0.031 12 (35.3) 0.044
C/T 98 (46.7) 24 (44.4) 5 (25.0) 19 (55.9)
T/T 62 (29.5) 9 (16.7) 6 (30.0) 3 (8.8)
ADRA2A 1291C>G NERD-FD
C/C 21 (9.9) 19 (18.6) 0.038 9 (24.3) 0.048 10 (15.4) 0.046
C/G 98 (46.0) 35 (34.3) 16 (43.2) 19 (29.2)
G/G 94 (44.1) 48 (47.1) 12 (32.4) 36 (55.4)
CCKAR intron 779T>C NERD-FD-IBS
T/T 113 (51.9) 24 (44.4) 0.429 11 (55.0) 0.234 13 (38.2) 0.456
T/C 84 (38.5) 26 (48.1) 9 (45.0) 17 (50.0)
C/C 21 (9.6) 4 (7.4) 0 (0.0) 4 (11.8)
TRPV1 945G>C NERD-FD-IBS
G/G 52 (24.9) 13 (24.5) 0.295 4 (20.0) 0.577 9 (27.3) 0.393
G/C 97 (46.4) 30 (56.6) 11 (55.0) 19 (57.6)
C/C 60 (28.7) 10 (18.9) 5 (25.0) 5 (15.2)
TNFA 308G>A NERD-FD-IBS
G/G 194 (93.3) 24 (80.0) 0.032 11 (78.6) 0.254 13 (81.3) 0.144
G/A 13 (6.3) 6 (20.0) 3 (21.4) 3 (18.8)
A/A 1 (0.4) 0 (0.0) 0 (0.0) 0 (0.0)
IL10 592C>A IBS only
C/C 29 (13.9) 0 (0.0) 0.047 0 (0.0) 0.009 0 (0.0) 0.653
C/A 86 (41.1) 8 (80.0) 7 (100.0) 1 (33.3)
A/A 94 (45.0) 2 (20.0) 0 (0.0) 2 (66.7)

aP-values compared to men controls.

bP-values compared to women controls.

FGID, functional gastrointestinal disorder; NERD, non-erosive reflux disease; FD, functional dyspepsia; IBS, irritable bowel syndrome; 5-HTTLPR, serotonin transporter long polymorphic region; GNB3, G-protein β3 gene; ADRA2A, alpha 2A adrenergic receptor gene; TRPV1, transient receptor potential ion channel of the vanilloid type 1; CCK1R, cholecystokinin receptor 1 gene; TNFA, tumor necrosis factor-α gene; IL, interleukin gene.

Data are expressed as n (%).
J Neurogastroenterol Motil 2022;28:145~158 https://doi.org/10.5056/jnm21047
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