Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 2.

Baseline Characteristics of Patients by Type of Esophageal Motility Disorder and Comparison With the Normal Motility Group

Characteristics Total (N = 394) Outflow obstruction group (n = 71) Hypermotility group (n = 15) Hypomotility group (n = 107) Normal motility group (n = 201) Outflow vs Normal motility Hyper vs Normal motility Hypo vs Normal motility
P-value P-value P-value
Sex (M/F) 211/183 35/36 8/7 61/46 107/94 0.583 1.000 0.550
Age (yr) 56.2 ± 16.6 59.0 ± 15.6 61.0 ± 13.5 55.7 ± 18.3 55.1 ± 16.1 0.080 0.175 0.790
BMI (kg/m2) 22.4 ± 3.76 22.3 ± 3.5 25.5 ± 4.7 22.4 ± 3.5 22.2 ± 4.2 0.829 0.001a 0.878
Comorbidity
Hypertension (none/untreated/treating) (%) 77.9/1.7/20.3 71.8/2.8/25.3 60.0/0.0/40.0 79.4/3.7/16.8 80.5/0.4/18.9 0.135 0.151 0.096
Diabetes mellitus (none/untreated/oral medicine/insulin use) (%) 93.1/0.7/5.0/1.0 90.1/2.8/5.6/1.4 80.0/0.0/20.0/0.0 93.4/0.9/2.7/1.8 94.5/0.0/4.9/0.4 0.093 0.060 0.259
Allergy (%) 18.0 18.3 40.0 16.8 16.9 0.716 0.039 1.000
Scleroderma (%) 1.8 1.4 0.0 3.7 1.0 1.000 1.000 0.187
Helicobacter pylori infection status (NE/none/current/past) (%) 74.8/9.6/1.7/13.7 66.1/12/2/10 6.6/6.6/6.6/80.0 76.6/6.5/0.9/14.9 76.1/8.9/1.4/13.4 0.600 0.385 0.744
Medical history
Gastrectomy (none/distal gastrectomy/others) (%) 98.7/1.2/0.0 100.0/0.0/0.0 93.3/6.6/0.0 100.0/0.0/0.0 98.0/1.9/0.0 0.576 1.000 0.193
Habits
Smoking, Brinkman index 0.0 (0.0-166.8) 0.0 (0.0-300.0) 435.0 (0.0-780.0)a 0.0 (0.0-0.0) 0.0 (0.0-187.5) 0.563 0.018a 0.290
Alcohol consumption (NE/none/light/heavy) (%) 1.0/43.9/39.8/15.2 47.8/32.3/19.7 0.0/40.0/26.6/33.3 0.0/49.5/42.0/8.4 1.9/39.8/42.2/15.9 0.284 0.198 0.109
Endoscopic finding
Erosive esophagitis (NE/none/A/B/C/D) (%) 12.9/47.7/29.2/7.4/2.0/0.7 19.7/52.1/19.7/8.4/0.0/0.0 13.3/73.3/6.6/6.6/0.0/0.0 10.2/48.5/28.9/6.5/4.6/0.9 11.9/43.7/34.3/7.4/1.4/0.9 0.184 0.170 0.443
Hiatal hernia (%) 39.8 16.9a 40.0 51.4 41.7 0.005a 0.787 0.127
Mucosal atrophy (NE/none/C-1,2,3/O-1,2,3) (%) 14.9/5.8/16.3/20.0 9.8/61.9/8.4/19.7 13.3/53.3/0.0/33.3 11.2/55.1/16.8/16.8 15.9/50.2/16.9/16.9 0.150 0.104 0.933
Symptom questionnaire
FSSG score
Reflux 11.3 ± 6.5 10.1 ± 6.4 11.5 ± 7.8 12.0 ± 6.6 11.2 ± 6.3 0.281 0.897 0.318
Dysmotility 8.1 ± 4.9 7.7 ± 5.0 8.0 ± 5.5 8.1 ± 4.8 8.2 ± 5.0 0.482 0.912 0.786
Dysphagia 1.6 ± 1.4 2.2 ± 1.5a 2.2 ± 1.3a 1.6 ± 1.3a 1.3 ± 1.2 0.047a 0.030a 0.022a
Total 19.4 ± 10.7 17.9 ± 10.7 19.6 ± 13.1 20.2 ± 10.7 19.5 ± 10.6 0.334 0.961 0.587
GSRS score
Total 36.3 ± 14.8 33.2 ± 13.6a 44.0 ± 18.3 34.8 ± 13.9 37.7 ± 15.3 0.030a 0.285 0.121
Average 2.4 ± 1.0 2.2 ± 0.9a 2.9 ± 1.2 2.3 ± 0.9 2.5 ± 1.0 0.039a 0.285 0.097
Acid reflux 6.2 ± 3.0 4.9 ± 2.5a 6.3 ± 3.8 6.4 ± 3.1 6.4 ± 3.0 0.001a 0.917 0.867
Abdominal pain 6.9 ± 3.9 6.3 ± 3.7 8.3 ± 5.1 6.8 ± 3.7 7.1 ± 4.0 0.238 0.442 0.601
Dyspepsia 10.1 ± 4.8 8.9 ± 4.1a 11.6 ± 5.5 10.0 ± 4.8 10.5 ± 5.0 0.030a 0.546 0.370
Diarrhea 5.7 ± 3.7 5.4 ± 3.7 7.9 ± 4.3 4.9 ± 3.1a 6.0 ± 3.9 0.249 0.204 0.009a
Constipation 7.3 ± 4.2 7.5 ± 4.6 9.8 ± 4.4 6.4 ± 3.6a 7.6 ± 4.3 0.943 0.136 0.017a
SF-8
PCS 42.7 ± 8.9 43.5 ± 9.0 41.6 ± 8.7 41.7 ± 8.4 43.0 ± 9.1 0.714 0.600 0.234
MCS 44.1 ± 8.3 43.6 ± 8.7 41.4 ± 8.4 45.3 ± 8.7 43.7 ± 8.0 0.925 0.397 0.127

aP < 0.05.

M, male; F, female; BMI, body mass index; H. pylori, Helicobacter pylori; NE, not evaluated; FSSG, frequency scale for symptoms of gastroesophageal reflux disease; GSRS, gastrointestinal symptom rating scale; SF-8, Short Form-8 Health Survey; PCS, physical component summary; MCS, mental component summary.

Data are presented as mean ± SD or median (range).

J Neurogastroenterol Motil 2021;27:545~554 https://doi.org/10.5056/jnm20131
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