Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Comparison Between Achalasia and Normal Motility Groups, and Esophageal Gastric Junction Outflow Obstruction and Normal Motility Groups

Characteristics Achalasia (n = 38) EGJ outflow obstruction (n = 33) Normal motility (n = 201) Achalasia vs Normal motility EGJ outflow obstruction vs Normal motility
P-value P-value
Sex (M/F) 19/19 16/17 107/94 0.714 0.613
Age (yr) 55.8 ± 16.2 62.7 ± 14.2a 55.1 ± 16.1 0.081 0.012a
BMI (kg/m2) 22.9 ± 4.5 21.4 ± 3.8 22.2 ± 4.2 0.344 0.167
Comorbidity
Hypertension (none/untreated/treating) (%) 71.0/5.2/23.6 72.7/0.0/27.2 80.5/0.4/18.9 0.041a 0.519
DM (none/untreated/oral medicine/insulin use) (%) 92.1/0.0/5.2/2.6 87.8/6.0/6.0/0.0 94.5/0.0/4.9/0.4 0.414 0.006a
Allergy (%) 15.7 21.2 16.9 0.855 0.449
Scleroderma (%) 0.0 3.0 1.0 0.537 0.335
H. pylori infection status (NE/none/current/past) (%) 55.2/23.6/5.2/15.7 78.7/9.0/0.0/12.1 76.1/8.9/1.4/13.4 0.444 0.888
Medical history
Gastrectomy (none/distal gastrectomy/others) (%) 100.0/0.0/0.0/0.0 100.0/0.0/0.0 98.0/1.9/0.0 0.380 0.414
Habits
Smoking, Brinkman index 0.0 (0-337.5) 0.0 (0-60.0) 0.0 (0.0-187.5) 0.136 0.749
Alcohol consumption (NE/none/light/heavy) (%) 0.0/47.3/36.8/15.7 0.0/48.4/27.2/24.2 1.9/39.8/42.2/15.9 0.721 0.202
Endoscopic finding
Erosive esophagitis (NE/none/A/B/C/D) (%) 28.9/60.5/10.5/0.0/0.0/0.0 9.0/42.4/30.3/18.1/0.0/0.0 11.9/43.7/34.3/7.4/1.4/0.9 0.015a 0.346
Hiatal hernia (%) 5.2a 30.3 41.7 < 0.001a 0.300
Mucosal atrophy (NE/none/C-1,2,3/O-1,2,3) (%) 13.1/55.2/10.5/21.0 6.0/69.6/6.0/18.1 15.9/50.2/16.9/16.9 0.540 0.165
Symptom questionnaire
FSSG score
Reflux 9.9 ± 6.2 10.3 ± 6.7 11.2 ± 6.3 0.330 0.496
Dysmotility 8.4 ± 5.7 7.1 ± 4.3 8.2 ± 5.0 0.904 0.247
Dysphagia 2.0 ± 1.4a 1.5 ± 1.5 1.3 ± 1.2 0.015a 0.593
Total 18.3 ± 11.5 17.5 ± 10.2 19.5 ± 10.6 0.615 0.349
GSRS score
Total 32.0 ± 12.6 34.3 ± 14.5 37.7 ± 15.3 0.070 0.253
Average 2.1 ± 0.8 2.2 ± 0.97 2.5 ± 1.0 0.070 0.253
Acid reflux 4.8 ± 2.4a 5.0 ± 2.7a 6.4 ± 3.0 0.010a 0.012a
Abdominal pain 6.8 ± 3.5 6.0 ± 3.9 7.1 ± 4.0 0.723 0.172
Dyspepsia 8.5 ± 3.3a 9.3 ± 4.7 10.5 ± 5.0 0.010a 0.203
Diarrhea 5.0 ± 3.4 5.7 ± 4.0 6.0 ± 3.9 0.174 0.678
Constipation 6.8 ± 4.6 8.1 ± 4.6 7.6 ± 4.3 0.389 0.486
SF-8
PCS 43.7 ± 10.1 43.4 ± 8.2 43.0 ± 9.1 0.724 0.838
MCS 42.9 ± 8.0 44.2 ± 9.2 43.7 ± 8.0 0.613 0.754

aP < 0.05.

EGJ, esophageal gastric junction; M, male; F, female; BMI, body mass index; DM, diabetes millitus; H. pylori, Helicobacter pylori; NE, not evaluated; FSSG, frequency scale for symptoms of gastroesophageal reflux disease; GSRS, gastrointestinal symptom rating scale; SF-8, Short Form-8 Health Survey; PCS, physical component summary; MCS, mental component summary.

Data are presented as mean ± SD or median (range).

J Neurogastroenterol Motil 2021;27:545~554 https://doi.org/10.5056/jnm20131
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