Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 1.

Baseline Characteristics of Patients With Non-erosive Reflux Disease and Functional Heartburn

Characteristics Total NERD
(n = 50)
FH
(n = 20)
NERD/PPI responders (n = 25) NERD/PPI nonresponders (n = 25)
Age (yr) 51.6 ± 14.0 56.3 ± 13.1 53.2 ± 12.9 50.1 ± 15.1
Male 27 (54) 9 (45) 14 (56) 13 (52)
DeMeester score 19.9 ± 11.9 6.0 ± 4.7a 24.0 ± 6.2 15.7 ± 14.7b
AET (%) 5.7 ± 3.4 1.7 ± 1.3a 6.9 ± 1.8 4.5 ± 4.2b
Acid refluxes 77.5 (44.3, 113.5) 20.0 (6.0, 39.0)a 100.0 (67.5, 146.0) 63.0 (28.0, 83.0)b
Weakly acid refluxes 19.0 (10.0, 37.3) 10.5 (6.0, 12.0)a 13.0 (5.0, 26.0) 26.0 (15.0,54.0)c
Weakly alkaline refluxes 2.0 (1.0, 5.8) 0 (0, 0)a 1.0 (1.0, 3.0) 3.0 (1.5, 13.0)
Long term acid (> 5 min) 3.0 (1.0, 5.0) 1.0 (0, 1.5)a 4.0 (2.0, 7.0) 1.0 (1.0, 5.0)b

NERD, non-erosive reflux disease; FH, functional heartburn; PPI, proton pump inhibitor; AET, acid exposure time.

aP-value < 0.001 compared with total NERD.

bP-value < 0.05 compared with NERD/PPI responders.

cP-value < 0.01 compared with NERD/PPI responders.

Data are presented as mean ± standard deviation, n (%), or median (interquartile range: 25th, 75th).

J Neurogastroenterol Motil 2021;27:525~532 https://doi.org/10.5056/jnm20073
© J Neurogastroenterol Motil