Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 1.

Prevalence and Risk Factors of Overlapping Functional Gastrointestinal Disorders and Gastroesophageal Reflux Disease

Author (yr) Area GERD definition FGIDs definition Total numbers of subjects Prevalence of overlapping GERD-FGID Risk factors of overlap
Jarbøl, DE. (2017)53 Denmark Montreal definition Rome III 100 000 subjects in a general population 1.9% with GERD-FD, 1.7% with GERD-IBS-C, 1.6% with GERD-FD-IBS-C
Guillemot et al,36 2005 France Questionnaire Rome II 3318 subjects with GERD 72.0% with any FGIDs (27.0% IBS, 16.0% FD, 57.0% both) More GERD symptoms
Aro et al,37 2011 Swedish Montreal definition Rome III 1001 subjects in a general population 3.9% with GERD-FD, 5.8% with GERD-FD-IBS
Lee et al,38 2014 Taiwan Montreal definition Rome III 48 subjects with GERD-FD, 63 subjects with GERD only Younger age, female
Rasmussen et al,41 2015 Denmark Montreal definition Rome III 49 706 subjects in a general population 11.2% with GERD, 7.7% with FD, 10.5% with IBS, 6.5% with overlap
Hsu et al,42 2015 Taiwan Questionnaire Rome III 2604 subjects in a health check-out cohort 79 subjects with GERD-IBS More severe GERD, more healthcare-seeking behavior, depression
Hsu et al,43 2017 Taiwan Questionnaire Rome III 868 subjects with GERD 107 subjects with GERD-FD IBS
Fujiwara et al,46 2011 Japan Questionnaire Rome III 2680 subjects in a health check-out cohort 6.0% with overlaps Cigarette smoking
Noh et al,47 2010 Korea Endoscopy Rome III 360 subjects with GERD 8.1% with FD, 10.1% with IBS NERD
Nam et al,48 2013 Korea Questionnaire and endoscopy Rome III 2769 subjects in a health check-out cohort 9.3% with IBS, 7.9% with NERD, 10.1% with EE NERD
Jung et al,49 2007 United States Questionnaire Rome III 2298 subjects in a general population 3.0% men with GERD-IBS, 4.0% women with GERD-IBS Insomnia, abdominal pain, somatization
Lee et al,50 2009 Korea Questionnaire Rome II 1443 subjects in a general population 2.3% with GERD-FD, 2.0% with GERD-IBS, 1.3% with FD-IBS Anxiety

GERD, gastroesophageal reflux disease; FGIDs, functional gastrointestinal disorders; FD, functional dyspepsia; EE, erosive esophagus; IBS, irritable bowel syndrome; IBS-C, irritable bowel syndrome with constipation; NERD, non-erosive reflux disease.

J Neurogastroenterol Motil 2021;27:176~184
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