Prevalence and Risk Factors of Overlapping Functional Gastrointestinal Disorders and Gastroesophageal Reflux Disease
| Author (yr) | Area | GERD definition | FGIDs definition | Total numbers of subjects | Prevalence of overlapping GERD-FGID | Risk factors of overlap |
|---|---|---|---|---|---|---|
| Jarbøl, DE. (2017)53 | Denmark | Montreal definition | Rome III | 100 000 subjects in a general population | 1.9% with GERD-FD, 1.7% with GERD-IBS-C, 1.6% with GERD-FD-IBS-C | |
| Guillemot et al,36 2005 | France | Questionnaire | Rome II | 3318 subjects with GERD | 72.0% with any FGIDs (27.0% IBS, 16.0% FD, 57.0% both) | More GERD symptoms |
| Aro et al,37 2011 | Swedish | Montreal definition | Rome III | 1001 subjects in a general population | 3.9% with GERD-FD, 5.8% with GERD-FD-IBS | |
| Lee et al,38 2014 | Taiwan | Montreal definition | Rome III | 48 subjects with GERD-FD, 63 subjects with GERD only | Younger age, female | |
| Rasmussen et al,41 2015 | Denmark | Montreal definition | Rome III | 49 706 subjects in a general population | 11.2% with GERD, 7.7% with FD, 10.5% with IBS, 6.5% with overlap | |
| Hsu et al,42 2015 | Taiwan | Questionnaire | Rome III | 2604 subjects in a health check-out cohort | 79 subjects with GERD-IBS | More severe GERD, more healthcare-seeking behavior, depression |
| Hsu et al,43 2017 | Taiwan | Questionnaire | Rome III | 868 subjects with GERD | 107 subjects with GERD-FD | IBS |
| Fujiwara et al,46 2011 | Japan | Questionnaire | Rome III | 2680 subjects in a health check-out cohort | 6.0% with overlaps | Cigarette smoking |
| Noh et al,47 2010 | Korea | Endoscopy | Rome III | 360 subjects with GERD | 8.1% with FD, 10.1% with IBS | NERD |
| Nam et al,48 2013 | Korea | Questionnaire and endoscopy | Rome III | 2769 subjects in a health check-out cohort | 9.3% with IBS, 7.9% with NERD, 10.1% with EE | NERD |
| Jung et al,49 2007 | United States | Questionnaire | Rome III | 2298 subjects in a general population | 3.0% men with GERD-IBS, 4.0% women with GERD-IBS | Insomnia, abdominal pain, somatization |
| Lee et al,50 2009 | Korea | Questionnaire | Rome II | 1443 subjects in a general population | 2.3% with GERD-FD, 2.0% with GERD-IBS, 1.3% with FD-IBS | Anxiety |
GERD, gastroesophageal reflux disease; FGIDs, functional gastrointestinal disorders; FD, functional dyspepsia; EE, erosive esophagus; IBS, irritable bowel syndrome; IBS-C, irritable bowel syndrome with constipation; NERD, non-erosive reflux disease.