Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 1.

Studies Focused on Specific Sex Hormones

Author, year Human/animal Specific hormone Sex/age Specific microorganism Interaction with microbiota
Colldén et al,21 2019 Mice T, DHT Both Germ-free mice study High glucuronidated T and DHT, low DHT
Shin et al,22 2019 Human T, E2 Male (37.45 ± 1.91) Acinetobacter, Dorea, Ruminococcus, and Megamonas Correlated with T level
Female (46.15 ± 2.26) Bacteroidetes, Firmicutes High E group had more Bacteroidetes and less Firmicutes
Slackia and Butyricimonas Correlated with E2 level
Hou et al,23 2019 Mice/cell T Male Doxycycline study Doxycycline induced T deficiency and sperm quality
Sherman et al,30 2018 Rat Prenatal T Female offspring Nocardiaceae, Clostridiaceae, Akkermansia, Bacteroides, Lactobacillus, Clostridium High Nocardiaceae and Clostridiaceae, low Akkermansia, Bacteroides, Lactobacillus, and Clostridium
Yurkovetskiy et al,24 2013 Mice T Both/castration Porphyromonadaceae, Veillonellaceae and Kineosporiaceae, Lactobacillaceae, etc T level correlated with microbiota
Zheng et al,25 2020 Rat DHT Female Bacteroidetes, diversity analyses DHT associated with microbiota disturbance
Liu et al,26 2017 Human T/LH/FSH Pre-menopausal female Bacteroides, Escherichia/Shigella, Streptococcus, Akkermansia, Ruminococcaceae Associated with the clinical parameters of PCOS
Liang et al,27 2020 Human T/LH/FSH/E2/DHEA Pre-menopausal female Bacteroidetes, Firmicutes, and Verrucomicrobia PCOS showed lower SVs and alpha diversity than did the control
Chu et al,31 2019 Rat T, AMH Female Parasutterella, Corynebacterium, Odoribacter, Acinetobacter Parasutterella was correlated with T
Jobira et al,28 2020 Human T Adolescent female Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, Porphyromonadaceae, Streptococcaceae PCOS showed difference in microbiota. α-Diversity was associated with T
Arroyo et al,29 2019 Mice T/LH Pubertal female Lactobacillus, Lachnospiraceae spp., Ruminococcus, Roseburia, Sutterella, Bifidobacterium, Parabacteroides, Blautia Letrozole treatment resulted in restoration of α/β diversity
Torres et al,32 2018 Human T Pre-menopausal female Porphyromonas spp., Bacteroides coprophilus Blautia spp., Faecalibacterium prausnitzii, Anaerococcus spp., Odoribacter spp., Roseburia spp., and Ruminococcus bromii PCOS was associated with reduced microbiome biodiversity
Xue et al,33 2019 Mice T/E2 Female Bifidobacterium, Proteobacteria, Helicobacter, Parasutterella Inulin and metformin alleviated PCOS by modulating gut microbiota
Org et al,34 2016 Mice DHT Both/GDX Ruminococcacea, Akkermansia Effect of GDX/hormone replacement on microbiota
Markle et al,35 2013 Mice T Both, young and old Roseburia, Blautia, Coprococcus 1, Parabacteroides, and Bilophilia Microbes protected autoimmune condition
Harada et al,36 2020 Mice T (ArKO) Both Turicibacter, Lactobacillus HFD-dependent metabolic disorders in ArKO males were abolished after antibiotic treatment
Harada et al,37 2016 Mice T Male/castration Firmicutes, Bacteroidetes, Lactobacillus Castration affected microbiome and obesity
Poutahidis et al,38 2014 Mice T Male Lactobacillus reuteri Probiotics improved testis function
Song et al,39 2020 Mice E2 Both/OVX Verrucomicrobia, Cyanobacteria, Firmicutes, Bacteroidetes E2 supplement affected AOM/DSS-treated mice

T, testosterone; DHT, dihydrotestosterone; E2, estradiol; LH, luteinizing hormone; FSH, follicle-stimulating hormone; PCOS, polycystic ovary disease; DHEA, dehydroepiandrosterone; SVs, structural variations; AMH, anti-Müllerian hormone; GDX, gonadectomy; HFD, high-fat diet; ArKO, aromatase-deficient mice; OVX, ovariectomy; AOM, azoxymethane; DSS, dextran sodium sulfate.
J Neurogastroenterol Motil 2021;27:314~325 https://doi.org/10.5056/jnm20208
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