Fig. 2. Forest plot shows the association between low birth weight and development of irritable bowel syndrome. Bengtson et al⁸ (2006) found low birth weight below 1500 g to be significantly associated with higher irritable bowel syndrome (IBS) risk after adjustment for gestational age and history of same health issues in both twins. Raslau et al⁹ (2016) found lower birth weight to be associated with increased odds of IBS. Waehrens et al¹⁰ (2018) found birth weight below 2500 g to be associated with increased risk of IBS after adjusting for sex, birth year, gestational age, fetal growth, birth order, delivery mode, multiple birth status, maternal age at delivery, maternal marital status, paternal length of education, maternal length of education as well as parental history of anxiety, depression, and IBS.

J Neurogastroenterol Motil 2020;26:437~446 https://doi.org/10.5056/jnm20109

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