Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Table. 3.

Effects of Carboxymethylcellulose and CSP01 on Bowel Symptoms, Patients Completing Study

Variables Placebo (n = 9) Carboxymethylcellulose (n = 11) CSP01 (n = 19) P-valuea



Baseline Post-Tx Baseline Post-Tx Baseline Post-Tx
Stool frequency per day 0.8 ± 0.4 0.9 ± 0.6 0.7 ± 0.4 0.8 ± 0.4 0.8 ± 0.3 1.0 ± 0.4 0.641
Stool consistency per BM (BSFS 1-7) 2.6 ± 1.1 2.7 ± 1.4 3.1 ± 1.1 3.6 ± 1.6 3.0 ± 1.2 3.8 ± 0.9 0.509
Ease of passage scale per BM (1-7) 3.9 ± 0.7 3.9 ± 0.6 3.5 ± 0.5 3.6 ± 0.6 3.6 ± 0.6 3.8 ± 0.4 0.098
Number of CSBMs/day 0.2 ± 0.3 0.3 ± 0.3 0.2 ± 0.2 0.3 ± 0.2 0.2 ± 0.2 0.3 ± 0.3 0.896
Daily constipation severity (1-10)b 4.2 ± 2.5 3.9 ± 2.5 4.0 ± 1.3 3.3 ± 1.2 4.1 ± 2.1 3.5 ± 1.8 0.586
Daily abdominal discomfort severity (1-10)b 3.8 ± 2.2 3.6 ± 2.6 3.6 ± 1.4 3.1 ± 1.4 3.9 ± 1.8 3.7 ± 1.9 0.796
Daily bloating severity (1-10)b 4.7 ± 2.5 4.0 ± 2.8 4.4 ± 1.4 3.9 ± 1.2 4.4 ± 2.2 4.2 ± 2.2 0.443
PAC-SYMb 15.3 ± 7.1 13.0 ± 8.0 17.5 ± 4.6 10.5 ± 4.8 18.0 ± 8.2 12.2 ± 7.3 0.422
PAC-QOLc 30.9 ± 14.1 28.6 ± 16.1 31.4 ± 6.0 21.0 ± 4.1 39.7 ± 16.6 27.7 ± 18.4 0.161

aP-values were calculated for effect of treatment type × time (pre-treatment vs last week of treatment) with the use of analysis of covariance with adjustment for age and sex.

bHigher values indicate increased severity of symptoms.

cHigher values indicate lower quality of life.

Tx, treatment; BM, bowel movement; BSFS, Bristol Stool Form Scale; CSBMs, complete spontaneous bowel movements; PAC-SYM, Patient Assessment of Constipation–Symptoms; PAC-QOL, Patient Assessment of Constipation–Quality of Life.

One patient in the placebo-treated irritable bowel syndrome with constipation group did not have a second wireless motility capsule colonic transit time because of a technical malfunction but did complete the symptom diary and was included in this analysis.

J Neurogastroenterol Motil 2020;26:496~504 https://doi.org/10.5056/jnm20001
© J Neurogastroenterol Motil