Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 6. Effects of ML204 (an inhibitor of transient receptor potential canonical 4 and 5 [TRPC4/5] channels) on spontaneous intracellular Ca2+ ([Ca2+]i) oscillations of small intestinal interstitial cells of Cajal (ICCs). (A) The application of ML204 (10 μM) increased spontaneous [Ca2+]i oscillations. A series of spontaneous [Ca2+]i oscillations were observed over a time period in ICCs loaded with Fluo-4 acetoxymethyl ester (AM). (B) Summarized frequency changing of ML204 action. Relative alterations of [Ca2+]i fluorescence emission intensity were expressed as the ratio (F1/F0), where F0 was taken from the fluorescence of first image. Bars represent mean ± SE values (n = 6 per group). *P < 0.05.
J Neurogastroenterol Motil 2020;26:521~528
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